MAFF (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000185022 T059764_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MAFF
M02853_2.00		 Homo sapiens
WTGCTGASTCAGCAN
NTGCTGASTCAGCAW		 SELEX
Jolma et al.(2013)
MAFF_1		 (Direct) (Direct)
MAFF
M04357_2.00		 Homo sapiens
NYGCTGASTCAGCRN
NYGCTGASTCAGCRN		 SELEX
Yin et al.(2017)
MAFF_eDBD_HT-SELEX_1		 (Direct) (Direct)
MAFF
M04358_2.00		 Homo sapiens
NYGCTKACGTMAGCRN
NYGCTKACGTMAGCRN		 SELEX
Yin et al.(2017)
MAFF_eDBD_HT-SELEX_2		 (Direct) (Direct)
MAFF
M04359_2.00		 Homo sapiens
NYGCTGASTCAGCRN
NYGCTGASTCAGCRN		 SELEX
Yin et al.(2017)
MAFF_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
MAFF
M04360_2.00		 Homo sapiens
DYGCTKACRTCAGCAN
NTGCTGAYGTMAGCRH		 SELEX
Yin et al.(2017)
MAFF_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
MAFF
M04361_2.00		 Homo sapiens
NYGCTGASTCAGCRN
NYGCTGASTCAGCRN		 SELEX
Yin et al.(2017)
MAFF_FL_HT-SELEX_1		 (Direct) (Direct)
MAFF
M04362_2.00		 Homo sapiens
NYGCTKACGTMAGCAN
NTGCTKACGTMAGCRN		 SELEX
Yin et al.(2017)
MAFF_FL_HT-SELEX_2		 (Direct) (Direct)
MAFF
M04363_2.00		 Homo sapiens
NYGCTGASTCAGCRN
NYGCTGASTCAGCRN		 SELEX
Yin et al.(2017)
MAFF_FL_Methyl-HT-SELEX_1		 (Direct) (Direct)
MAFF
M04364_2.00		 Homo sapiens
NYGCTGAYGTCAGCRH
DYGCTGACRTCAGCRN		 SELEX
Yin et al.(2017)
MAFF_FL_Methyl-HT-SELEX_2		 (Direct) (Direct)
MAFF
M07839_2.00		 Homo sapiens
TGCTGASTCAGCANW
WNTGCTGASTCAGCA		 ChIP-seq
Gerstein et al.(2012)
HepG2_MAFF_Stanford		 (Direct) (Direct)
MAFF
M08074_2.00		 Homo sapiens
NWWNTGCTGASTCAGCANWWH
DWWNTGCTGASTCAGCANWWN		 ChIP-seq
Mathelier et al.(2014)
MA0495.2		 (Direct) (Direct)
MAFF
M08808_2.00		 Homo sapiens
NRDDNWGMTRASTCAGCA
TGCTGASTYAKCWNHHYN		 Misc
Kulakovskiy et al.(2013)
MAFF_HUMAN.H11MO.0.B		 (Direct) (Direct)
MAFF
M10012_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MAFF_02		 (Direct) (Direct)
MAFF
M10013_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MAFF_04		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Maff
M08834_2.00 		Mus musculus
NWHNTGCTGASTCAGCANWYYN
NRRWNTGCTGASTCAGCANDWN		 Misc
Kulakovskiy et al.(2013)
MAFF_MOUSE.H11MO.0.A 		0.983 1.000
Maff
M10032_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MAFF_03 		0.983 1.000
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000345393 bZIP 50 117
ENSP00000384094 bZIP 50 117
ENSP00000388882 bZIP 50 117
ENSP00000391589 bZIP 20 88
ENSP00000416493 bZIP 49 117
ENSP00000441482 bZIP 20 88
ENSP00000442060 bZIP 50 117

Links

Other bZIP family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

62 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action