Xbp1 (Mus musculus)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSMUSG00000020484 T060458_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding activity; and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in several processes, including cellular response to hexose stimulus; lipid homeostasis; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; exocrine system development; and positive regulation of proteasomal protein catabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study inflammatory bowel disease. Orthologous to human XBP1 (X-box binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Xbp1
M00757_2.00		 Mus musculus
NNHBAYDNNN
NNNHRTVDNN		 PBM
Weirauch et al.(2013)
pTH2852		 (Direct) (Direct)
Xbp1
M01802_2.00		 Mus musculus
NHNACGYNN
NNRCGTNDN		 PBM
Weirauch et al.(2014)
pTH5019		 (Direct) (Direct)
Xbp1
M08818_2.00		 Mus musculus
GACGTGKCMHWD
HWDKGMCACGTC		 Misc
Kulakovskiy et al.(2013)
XBP1_MOUSE.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
XBP1
M02825_2.00 		Homo sapiens
GVTGACGTCABB
VVTGACGTCABC		 SELEX
Jolma et al.(2013)
XBP1_1 		0.830 0.931
XBP1
M02826_2.00 		Homo sapiens
GVTGACGTGKCVHW
WDBGMCACGTCABC		 SELEX
Jolma et al.(2013)
XBP1_2 		0.830 0.931
XBP1
M02730_2.00 		Homo sapiens
GACGTGKCNNW
WNNGMCACGTC		 SELEX
Jolma et al.(2010)
XBP1_monomer 		0.872 0.969
XBP1
M04231_2.00 		Homo sapiens
NVTGACGTGKNN
NNMCACGTCABN		 SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_1 		0.830 0.931
XBP1
M04232_2.00 		Homo sapiens
NVTKACGTMABV
BVTKACGTMABN		 SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_2 		0.830 0.931
XBP1
M04010_2.00 		Homo sapiens
GRTGACGTGKCV
BGMCACGTCAYC		 SELEX
Rodriguez-Martinez et al.(2017)
XBP1.1 		0.830 0.931
XBP1
M04011_2.00 		Homo sapiens
GRTGACGTCAYS
SRTGACGTCAYC		 SELEX
Rodriguez-Martinez et al.(2017)
XBP1.2 		0.830 0.931
XBP1
M04012_2.00 		Homo sapiens
KGMCACGTGKMCH
DGKMCACGTGKCM		 SELEX
Rodriguez-Martinez et al.(2017)
XBP1.3 		0.830 0.931
XBP1
M09932_2.00 		Homo sapiens
NHNWDHRVTGACGTGKHNHWDDHB
VDHHWDNDMCACGTCABYDHWNDN		 Transfac
Matys et al.(2006)
V$HTF_01 		0.830 0.931
XBP1
M09933_2.00 		Homo sapiens
DBRHTKACGTGKHNHWD
HWDNDMCACGTMADYVH		 Transfac
Matys et al.(2006)
V$XBP1_01 		0.830 0.931
XBP1
M04233_2.00 		Homo sapiens
BKMCACRTCAYS
SRTGAYGTGKMV		 SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_1 		0.872 0.969
XBP1
M04234_2.00 		Homo sapiens
VVTGWCRTCAYS
SRTGAYGWCABB		 SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_2 		0.830 0.931
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00757_2.00 bZIP 16 79
M01802_2.00 bZIP 16 79

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000054852 bZIP 61 124
ENSMUSP00000134088 bZIP 1 56
ENSMUSP00000135768 bZIP 14 71

Links

Other bZIP family TFs
Other Mus musculus TFs

59 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSNLEG00000002404 Nomascus leucogenys ENSNLEG00000002404 I 0.872
ENSOARG00000002962 Ovis aries ENSOARG00000002962 I 0.872
XBP1 Homo sapiens ENSG00000100219 D 0.872
ENSMLUG00000001735 Myotis lucifugus ENSMLUG00000001735 I 0.872
XBP1 Gorilla gorilla ENSGGOG00000007154 I 0.872
ENSMPUG00000013524 Mustela putorius furo ENSMPUG00000013524 I 0.872
XBP1 Microcebus murinus ENSMICG00000004235 I 0.872
XBP1 Macaca mulatta ENSMMUG00000007215 I 0.872
XBP1 Sorex araneus ENSSARG00000002418 I 0.872
XBP1 Equus caballus ENSECAG00000014780 I 0.872
ENSOPRG00000013983 Ochotona princeps ENSOPRG00000013983 I 0.872
ENSPVAG00000004528 Pteropus vampyrus ENSPVAG00000004528 I 0.872
ENSCAFG00000011954 Canis familiaris ENSCAFG00000011954 I 0.872
XBP1 Bos taurus ENSBTAG00000005970 I 0.872
Xbp1 Rattus norvegicus ENSRNOG00000010298 I 0.872
ENSPANG00000000372 Papio anubis ENSPANG00000000372 I 0.872
XBP1 Pan troglodytes ENSPTRG00000014210 I 0.872
ENSPPYG00000011678 Pongo abelii ENSPPYG00000011678 I 0.872
ENSCSAG00000009947 Chlorocebus sabaeus ENSCSAG00000009947 I 0.872
XBP1 Cavia porcellus ENSCPOG00000007796 I 0.872
XBP1 Loxodonta africana ENSLAFG00000029029 I 0.868
ENSTSYG00000000515 Tarsius syrichta ENSTSYG00000000515 I 0.864
ENSLOCG00000003156 Lepisosteus oculatus ENSLOCG00000003156 I 0.863
ENSSHAG00000010795 Sarcophilus harrisii ENSSHAG00000010795 I 0.862
ENSGMOG00000000538 Gadus morhua ENSGMOG00000000538 I 0.861
xbp1.L Xenopus laevis XB-GENE-487128 I 0.857
xbp1 Xenopus tropicalis XB-GENE-487124 I 0.857
ENSFALG00000008312 Ficedula albicollis ENSFALG00000008312 I 0.853
Aan_R010399 Calypte anna Aan_R010399 I 0.853
XBP1 Taeniopygia guttata ENSTGUG00000007938 I 0.853
xbp1 Takifugu rubripes ENSTRUG00000016185 I 0.849
ENSPFOG00000014555 Poecilia formosa ENSPFOG00000014555 I 0.849
ENSONIG00000010547 Oreochromis niloticus ENSONIG00000010547 I 0.849
XBP1 Tetraodon nigroviridis ENSTNIG00000015621 I 0.849
ENSXMAG00000002665 Xiphophorus maculatus ENSXMAG00000002665 I 0.849
xbp1 Gasterosteus aculeatus ENSGACG00000014266 I 0.848
ENSAMXG00000004136 Astyanax mexicanus ENSAMXG00000004136 I 0.848
ENSMODG00000023331 Monodelphis domestica ENSMODG00000023331 I 0.848
xbp1 Danio rerio ENSDARG00000035622 I 0.847
AAI60967 Xenopus tropicalis AAI60967 I 0.847
XBP1 Gallus gallus ENSGALG00000005796 I 0.832
ENSMMUP00000009460 Macaca fascicularis ENSMMUP00000009460 I 0.830
Myotis_brandtii_XBP1_10027497 Myotis brandtii Myotis_brandtii_XBP1_10027497 I 0.830
ENSP00000343155-D2 Bos grunniens ENSP00000343155-D2 I 0.830
XBP1 Ornithorhynchus anatinus ENSOANG00000008817 I 0.830
ENSDNOG00000034497 Dasypus novemcinctus ENSDNOG00000034497 I 0.830
XBP1 Callithrix jacchus ENSCJAG00000020084 I 0.830
ENSCHOG00000011608 Choloepus hoffmanni ENSCHOG00000011608 I 0.830
ENSFCAG00000028366 Felis catus ENSFCAG00000028366 I 0.830
ENSSTOG00000004168 Ictidomys tridecemlineatus ENSSTOG00000004168 I 0.830
ENSOCUG00000006928 Oryctolagus cuniculus ENSOCUG00000006928 I 0.830
ENSAMEG00000008458 Ailuropoda melanoleuca ENSAMEG00000008458 I 0.830
NEMVEDRAFT_v1g211292 Nematostella vectensis NEMVEDRAFT_v1g211292 I 0.827
ENSTBEG00000000324 Tupaia belangeri ENSTBEG00000000324 I 0.815
Pvit_02423 Pogona vitticeps Pvit_02423 I 0.811
ENSMGAG00000007147 Meleagris gallopavo ENSMGAG00000007147 I 0.789
XBP1 Procavia capensis ENSPCAG00000004565 N 0.782
ENSMEUG00000001794 Macropus eugenii ENSMEUG00000001794 I 0.770