Atf2 (Mus musculus)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSMUSG00000027104 T060469_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; histone acetylation; and intracellular signal transduction. Acts upstream of or within with a positive effect on regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adipose tissue development; fat cell differentiation; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Atf2
M01808_2.00		 Mus musculus
NRTKAYGYMD
HKRCRTMAYN		 PBM
Weirauch et al.(2014)
pTH5083		 (Direct) (Direct)
Atf2
M08827_2.00		 Mus musculus
VTGACVTCABY
RVTGABGTCAB		 Misc
Kulakovskiy et al.(2013)
ATF2_MOUSE.H11MO.0.A		 (Direct) (Direct)
Atf2
M09493_2.00		 Mus musculus
NNVTGABVTCAB
VTGABVTCABNN		 Misc
Heinz et al.(2010)
3T3L1-Atf2_GSE56872		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Creb5
M02866_2.00 		Mus musculus
NATGACGTCAYH
DRTGACGTCATN		 SELEX
Jolma et al.(2013)
Creb5_1 		0.901 0.812
CREB5
M04299_2.00 		Homo sapiens
NVTKACRTMABN
NVTKAYGTMABN		 SELEX
Yin et al.(2017)
CREB5_eDBD_HT-SELEX 		0.844 0.826
CREB5
M04301_2.00 		Homo sapiens
NRTKACGTMAYN
NRTKACGTMAYN		 SELEX
Yin et al.(2017)
CREB5_FL_HT-SELEX 		0.844 0.722
CREB5
M04300_2.00 		Homo sapiens
NRTKACRTCAYN
NRTGAYGTMAYN		 SELEX
Yin et al.(2017)
CREB5_eDBD_Methyl-HT-SELEX 		0.844 0.722
CREB5
M04302_2.00 		Homo sapiens
NATGACRTCAYN
NRTGAYGTCATN		 SELEX
Yin et al.(2017)
CREB5_FL_Methyl-HT-SELEX 		0.901 0.812
Atf7
M01823_2.00 		Mus musculus
HKACGTMAYN
NRTKACGTMD		 PBM
Weirauch et al.(2014)
pTH5081 		0.886 0.828
asl-1
M01147_2.00 		Neurospora crassa
NVTKACGHNN
NNDCGTMABN		 PBM
Lambert et al.(2019)
pTH8918 		0.787 0.516
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01808_2.00 bZIP 16 79

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000058521 bZIP 332 395
ENSMUSP00000088311 bZIP 292 355
ENSMUSP00000097588 bZIP 332 395
ENSMUSP00000107638 bZIP 292 355
ENSMUSP00000107641 bZIP 292 355
ENSMUSP00000107647 bZIP 234 297
ENSMUSP00000107648 bZIP 332 395
ENSMUSP00000114828 bZIP 126 179
ENSMUSP00000118357 C2H2 ZF 7 31
ENSMUSP00000118560 C2H2 ZF 7 31
ENSMUSP00000133632 bZIP 332 377

Links

Other bZIP family TFs
Other Mus musculus TFs

Invalid Input OrderBy

291 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action