Atf4 (Mus musculus)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSMUSG00000042406 T060486_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and promoter-specific chromatin binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including PERK-mediated unfolded protein response; animal organ development; and regulation of gene expression. Acts upstream of or within several processes, including gluconeogenesis; positive regulation of sodium-dependent phosphate transport; and positive regulation of vascular associated smooth muscle cell apoptotic process. Located in cytoplasm and nucleus. Part of ATF1-ATF4 transcription factor complex and ATF4-CREB1 transcription factor complex. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and long bone. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Atf4
M00759_2.00		 Mus musculus
NNNNKRCDHVHNN
NNDBDHGYMNNNN		 PBM
Weirauch et al.(2013)
pTH1014		 (Direct) (Direct)
Atf4
M02865_2.00		 Mus musculus
DRBATGAYGCAATM
KATTGCRTCATVYH		 SELEX
Jolma et al.(2013)
Atf4_1		 (Direct) (Direct)
Atf4
M08833_2.00		 Mus musculus
DNMTGATGCAAY
RTTGCATCAKNH		 Misc
Kulakovskiy et al.(2013)
ATF4_MOUSE.H11MO.0.A		 (Direct) (Direct)
Atf4
M09496_2.00		 Mus musculus
MTGATGYAAY
RTTRCATCAK		 Misc
Heinz et al.(2010)
MEF-Atf4_GSE35681		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ATF4
M02834_2.00 		Homo sapiens
DNMTGAYGCAAYM
KRTTGCRTCAKNH		 SELEX
Jolma et al.(2013)
ATF4_1 		0.914 0.984
ATF4
M04274_2.00 		Homo sapiens
RDATGACGTCATHY
RDATGACGTCATHY		 SELEX
Yin et al.(2017)
ATF4_eDBD_HT-SELEX 		0.914 0.984
ATF4
M04276_2.00 		Homo sapiens
RKATGACGTCATMY
RKATGACGTCATMY		 SELEX
Yin et al.(2017)
ATF4_FL_HT-SELEX 		0.914 0.984
ATF4
M04027_2.00 		Homo sapiens
VNATGACGTCABNY
RNVTGACGTCATNB		 SELEX
Rodriguez-Martinez et al.(2017)
ATF4.1 		0.914 0.984
ATF4
M08796_2.00 		Homo sapiens
DNMTGATGCAAY
RTTGCATCAKNH		 Misc
Kulakovskiy et al.(2013)
ATF4_HUMAN.H11MO.0.A 		0.914 0.984
ATF4
M09963_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ATF4_Q2 		0.914 0.984
ATF4
M09964_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ATF4_Q5 		0.914 0.984
ATF4
M09965_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ATF4_Q6 		0.914 0.984
ATF4
M04275_2.00 		Homo sapiens
RKATGACATCATCY
RGATGATGTCATMY		 SELEX
Yin et al.(2017)
ATF4_eDBD_Methyl-HT-SELEX 		0.914 0.984
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00759_2.00 bZIP 16 79

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000105234 bZIP 274 337

Links

Other bZIP family TFs
Other Mus musculus TFs

Invalid Input OrderBy

81 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action