ces-2 (Caenorhabditis elegans)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 WBGene00000469 T069397_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and identical protein binding activity. Involved in aging; apoptotic process; and positive regulation of programmed cell death. Predicted to be active in nucleus. Is expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including DBP (D-box binding PAR bZIP transcription factor) and TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ces-2
M01830_2.00		 Caenorhabditis elegans
ATTAYRTAA
TTAYRTAAT		 PBM
Weirauch et al.(2014)
pTH9480		 (Direct) (Direct)
ces-2
M10052_2.00		 Caenorhabditis elegans
RTTACGYAAY
RTTRCGTAAY		 Transfac
Matys et al.(2006)
N$CES2_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01830_2.00 bZIP 57 113

DNA Binding Domains

Protein ID Domain From To Sequence
ZK909.4 bZIP 120 176

Links

Other bZIP family TFs
Other Caenorhabditis elegans TFs

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBG19808 Caenorhabditis briggsae CBG19808 I 0.851
CBN32559 Caenorhabditis brenneri CBN32559 I 0.851
CJA10655 Caenorhabditis japonica CJA10655 I 0.841
CRE13954 Caenorhabditis remanei CRE13954 I 0.827
SMUV_0001027601 Syphacia muris SMUV_0001027601 I 0.825
L893_g26459 Steinernema glaseri L893_g26459 I 0.821
L898_g30246 Steinernema monticolum L898_g30246 I 0.821
L596_g3194 Steinernema carpocapsae L596_g3194 I 0.821
ASU_05094 Ascaris suum ASU_05094 I 0.818
ASIM_0001335601 Anisakis simplex ASIM_0001335601 I 0.818
ALUE_0000326401 Ascaris lumbricoides ALUE_0000326401 I 0.818
L889_g9945 Steinernema feltiae L889_g9945 I 0.815
DME_0000215901 Dracunculus medinensis DME_0000215901 I 0.814
nAv.1.0.1.g06570 Acanthocheilonema viteae nAv.1.0.1.g06570 I 0.811
GPUH_0000579801 Gongylonema pulchrum GPUH_0000579801 I 0.811
nOo.2.0.1.g09202 Onchocerca ochengi nOo.2.0.1.g09202 I 0.811
SPAL_0001536200 Strongyloides papillosus SPAL_0001536200 I 0.811
SSTP_0000025200 Strongyloides stercoralis SSTP_0000025200 I 0.811
SVE_0152400 Strongyloides venezuelensis SVE_0152400 I 0.811
PTRK_0001316500 Parastrongyloides trichosuri PTRK_0001316500 I 0.811
OFLC_0001455401 Onchocerca flexuosa OFLC_0001455401 I 0.811
nDi.2.2.2.g10294 Dirofilaria immitis nDi.2.2.2.g10294 I 0.811
nLs.2.1.2.g06633 Litomosoides sigmodontis nLs.2.1.2.g06633 I 0.811
nDi.2.2.2.g01315 Dirofilaria immitis nDi.2.2.2.g01315 I 0.811
EEL_0000071901 Elaeophora elaphi EEL_0000071901 I 0.811
WBGene00237430 Onchocerca volvulus WBGene00237430 I 0.811
LOAG_04491 Loa loa LOAG_04491 I 0.811
WUBG_01294 Wuchereria bancrofti WUBG_01294 I 0.811
BTMF_0000617301 Brugia timori BTMF_0000617301 I 0.811
Bm7588 Brugia malayi Bm7588 I 0.811
PEQ_0001019701 Parascaris equorum PEQ_0001019701 I 0.807
BGLB003270 Biomphalaria glabrata BGLB003270 I 0.804
HPLM_0000323401 Haemonchus placei HPLM_0000323401 I 0.800
ACOC_0001241401 Angiostrongylus costaricensis ACOC_0001241401 I 0.796
EVEC_0000550601 Enterobius vermicularis EVEC_0000550601 I 0.792
DICVIV_06567 Dictyocaulus viviparus DICVIV_06567 I 0.791
ANCCAN_03294 Ancylostoma caninum ANCCAN_03294 I 0.790
HCOI01537900 Haemonchus contortus HCOI01537900 I 0.790
SVUK_0000058801 Strongylus vulgaris SVUK_0000058801 I 0.790
HPLM_0000755401 Haemonchus placei HPLM_0000755401 I 0.790
ANCCEY_09166 Ancylostoma ceylanicum ANCCEY_09166 I 0.790
ASIM_0000214101 Anisakis simplex ASIM_0000214101 I 0.789
TCNE_0000328801 Toxocara canis TCNE_0000328801 I 0.789
SMAR014806 Strigamia maritima SMAR014806 I 0.787
ISCW006531 Ixodes scapularis ISCW006531 I 0.787
Bm3413 Brugia malayi Bm3413 I 0.785
nAv.1.0.1.g04605 Acanthocheilonema viteae nAv.1.0.1.g04605 I 0.785
WUBG_00008 Wuchereria bancrofti WUBG_00008 I 0.785
BTMF_0000787301 Brugia timori BTMF_0000787301 I 0.785
EEL_0000232301 Elaeophora elaphi EEL_0000232301 I 0.785
BGLB009720 Biomphalaria glabrata BGLB009720 I 0.785
WBGene00243299 Onchocerca volvulus WBGene00243299 I 0.785
nDi.2.2.2.g04619 Dirofilaria immitis nDi.2.2.2.g04619 I 0.785
SPU_021150 Strongylocentrotus purpuratus SPU_021150 I 0.784
Hba_18554 Heterorhabditis bacteriophora Hba_18554 I 0.782