GCN4 (Saccharomyces cerevisiae)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 YEL009C T069491_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of cellular response to amino acid starvation; protein localization to nuclear periphery; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GCN4
M01523_2.00		 Saccharomyces cerevisiae
NRTGASDNNN
NNNHSTCAYN		 PBM
Zhu et al.(2009)
Gcn4		 (Direct) (Direct)
GCN4
M08493_2.00		 Saccharomyces cerevisiae
RTGASTCA
TGASTCAY		 Misc
DeBoer et al.(2011)
YEL009C_1363		 (Direct) (Direct)
GCN4
M10055_2.00		 Saccharomyces cerevisiae
NSHSNNNNNRTGACTCAYHSHNNNNHN
NDNNNNDSDRTGAGTCAYNNNNNSDSN		 Transfac
Matys et al.(2006)
F$GCN4_01		 (Direct) (Direct)
GCN4
M10056_2.00		 Saccharomyces cerevisiae
VRRTGACTCH
DGAGTCAYYB		 Transfac
Matys et al.(2006)
F$GCN4_C		 (Direct) (Direct)
GCN4
M10057_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$GCN4_Q2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01523_2.00 bZIP 227 280

DNA Binding Domains

Protein ID Domain From To Sequence
YEL009C bZIP 227 280

Links

Other bZIP family TFs
Other Saccharomyces cerevisiae TFs

Invalid Input OrderBy

2 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action