|
|
ENSBTAP00000023213-D1
(Bos grunniens)
bZIP
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
| PF00170 (bZIP_1) |
IPR011616 |
ENSBTAP00000023213-D1 |
T070124_2.00 |
GigaDB (2015-Oct-22) |
| NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
| No direct experiments |
|
|
|
|
|
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Atf4
M00759_2.00 |
Mus musculus |
NNNNKRCDHVHNN |
NNDBDHGYMNNNN |
PBM
Weirauch et al.(2013)
pTH1014
|
0.914
|
1.000
|
Atf4
M02865_2.00 |
Mus musculus |
DRBATGAYGCAATM |
KATTGCRTCATVYH |
SELEX
Jolma et al.(2013)
Atf4_1
|
0.914
|
1.000
|
Atf4
M08833_2.00 |
Mus musculus |
DNMTGATGCAAY |
RTTGCATCAKNH |
Misc
Kulakovskiy et al.(2013)
ATF4_MOUSE.H11MO.0.A
|
0.914
|
1.000
|
Atf4
M09496_2.00 |
Mus musculus |
MTGATGYAAY |
RTTRCATCAK |
Misc
Heinz et al.(2010)
MEF-Atf4_GSE35681
|
0.914
|
1.000
|
ATF4
M02834_2.00 |
Homo sapiens |
DNMTGAYGCAAYM |
KRTTGCRTCAKNH |
SELEX
Jolma et al.(2013)
ATF4_1
|
0.914
|
0.984
|
ATF4
M04274_2.00 |
Homo sapiens |
RDATGACGTCATHY |
RDATGACGTCATHY |
SELEX
Yin et al.(2017)
ATF4_eDBD_HT-SELEX
|
0.914
|
0.984
|
ATF4
M04276_2.00 |
Homo sapiens |
RKATGACGTCATMY |
RKATGACGTCATMY |
SELEX
Yin et al.(2017)
ATF4_FL_HT-SELEX
|
0.914
|
0.984
|
ATF4
M04027_2.00 |
Homo sapiens |
VNATGACGTCABNY |
RNVTGACGTCATNB |
SELEX
Rodriguez-Martinez et al.(2017)
ATF4.1
|
0.914
|
0.984
|
ATF4
M08796_2.00 |
Homo sapiens |
DNMTGATGCAAY |
RTTGCATCAKNH |
Misc
Kulakovskiy et al.(2013)
ATF4_HUMAN.H11MO.0.A
|
0.914
|
0.984
|
ATF4
M09963_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$ATF4_Q2
|
0.914
|
0.984
|
ATF4
M09964_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$ATF4_Q5
|
0.914
|
0.984
|
ATF4
M09965_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$ATF4_Q6
|
0.914
|
0.984
|
ATF4
M04275_2.00 |
Homo sapiens |
RKATGACATCATCY |
RGATGATGTCATMY |
SELEX
Yin et al.(2017)
ATF4_eDBD_Methyl-HT-SELEX
|
0.914
|
0.984
|
| For this family, TFs with SR scores > 0.782 will likely have a similar motif |