ENSP00000228865 (Macaca fascicularis)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00170 (bZIP_1) IPR011616 ENSP00000228865 T070147_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CG18619
M03649_2.00
Drosophila melanogaster
RTKACGTMAT

ATKACGTMAY
SELEX
Nitta et al.(2015)
CG18619_1
0.869 0.635
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000228865 bZIP 19 83

Links

Other bZIP family TFs
Other Macaca fascicularis TFs

140 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AAEL007444 Aedes aegypti AAEL007444 I 0.850
AALB001171 Anopheles albimanus AALB001171 I 0.850
Aan_R002649 Calypte anna Aan_R002649 I 0.948
AARA010836 Anopheles arabiensis AARA010836 I 0.850
AATE008880 Anopheles atroparvus AATE008880 I 0.860
ACEP23224 Atta cephalotes ACEP23224 N 0.790
ACHR008657 Anopheles christyi ACHR008657 I 0.811
ACOM028166 Anopheles coluzzii ACOM028166 I 0.850
ACUA008740 Anopheles culicifacies ACUA008740 I 0.860
ACYPI000682 Acyrthosiphon pisum ACYPI000682 I 0.860
ADAC004626 Anopheles darlingi ADAC004626 I 0.850
ADIR004909 Anopheles dirus ADIR004909 I 0.850
AEPI001227 Anopheles epiroticus AEPI001227 I 0.811
AFAF011345 Anopheles farauti AFAF011345 I 0.860
Afo_R011193 Aptenodytes forsteri Afo_R011193 I 0.948
AFUN010381 Anopheles funestus AFUN010381 I 0.860
AGAP008762 Anopheles gambiae AGAP008762 I 0.850
Alligator_sinensis_CCG021184.1 Alligator sinensis Alligator_sinensis_CCG021184.1 I 0.948
AMEC006264 Anopheles melas AMEC006264 I 0.850
AMEM009899 Anopheles merus AMEM009899 I 0.850
AMIN001400 Anopheles minimus AMIN001400 I 0.850
AQUA005286 Anopheles quadriannulatus AQUA005286 I 0.850
ASIS000055 Anopheles sinensis ASIS000055 I 0.860
ASTEI094952 Anopheles stephensi ASTEI094952 I 0.860
BGIBMGA009250 Bombyx mori BGIBMGA009250 I 0.860
BGLB010118 Biomphalaria glabrata BGLB010118 I 0.884
Brh_R010115 Buceros rhinoceros Brh_R010115 I 0.948
CapteG70142 Capitella teleta CapteG70142 I 0.839
CapteG81335 Capitella teleta CapteG81335 I 0.839
CGI_10010182 Crassostrea gigas CGI_10010182 I 0.907
CLEC011539 Cimex lectularius CLEC011539 N 0.787
Cmyd_10012597 Chelonia mydas Cmyd_10012597 I 0.948
CPIJ011725 Culex quinquefasciatus CPIJ011725 I 0.849
CPIJ020318 Culex quinquefasciatus CPIJ020318 I 0.849
CpipJ_CPIJ011725 Culex pipiens CpipJ_CPIJ011725 I 0.849
CpipJ_CPIJ020318 Culex pipiens CpipJ_CPIJ020318 I 0.849
DAPPUDRAFT_227362 Daphnia pulex DAPPUDRAFT_227362 I 0.885
CREBL2 Anolis carolinensis ENSACAG00000004363 I 0.948
ENSAMEG00000010773 Ailuropoda melanoleuca ENSAMEG00000010773 I 0.948
ENSAMXG00000000720 Astyanax mexicanus ENSAMXG00000000720 I 0.948
ENSAPLG00000013223 Anas platyrhynchos ENSAPLG00000013223 I 0.948
CREBL2 Bos taurus ENSBTAG00000011957 I 0.948
CREBL2 Canis familiaris ENSCAFG00000013248 I 0.948
CREBL2 Choloepus hoffmanni ENSCHOG00000008864 I 0.948
CREBL2 Callithrix jacchus ENSCJAG00000021638 I 0.948
ENSCPOG00000010295 Cavia porcellus ENSCPOG00000010295 I 0.948
ENSCSAG00000008595 Chlorocebus sabaeus ENSCSAG00000008595 I 0.948
crebl2 Danio rerio ENSDARG00000104049 I 0.947
CREBL2 Dasypus novemcinctus ENSDNOG00000014119 I 0.948
ENSDORG00000000996 Dipodomys ordii ENSDORG00000000996 I 0.947
CREBL2 Equus caballus ENSECAG00000022654 I 0.948
CREBL2 Echinops telfairi ENSETEG00000008519 I 0.948
ENSFALG00000004638 Ficedula albicollis ENSFALG00000004638 I 0.948
CREBL2 Felis catus ENSFCAG00000030068 I 0.948
CREBL2 Homo sapiens ENSG00000111269 I 0.948
crebl2 Gasterosteus aculeatus ENSGACG00000000613 I 0.948
ENSGALG00000028812 Gallus gallus ENSGALG00000028812 I 0.948
CREBL2 Gorilla gorilla ENSGGOG00000024494 I 0.948
ENSGMOG00000017023 Gadus morhua ENSGMOG00000017023 I 0.948
ENSLACG00000018450 Latimeria chalumnae ENSLACG00000018450 I 0.924
CREBL2 Loxodonta africana ENSLAFG00000005950 I 0.948
ENSLOCG00000016490 Lepisosteus oculatus ENSLOCG00000016490 I 0.948
ENSMEUG00000007025 Macropus eugenii ENSMEUG00000007025 I 0.862
CREBL2 Meleagris gallopavo ENSMGAG00000013274 I 0.948
CREBL2 Myotis lucifugus ENSMLUG00000003150 I 0.948
CREBL2 Macaca mulatta ENSMMUG00000006677 I 0.948
ENSMODG00000027835 Monodelphis domestica ENSMODG00000027835 I 0.932
ENSMPUG00000011740 Mustela putorius furo ENSMPUG00000011740 I 0.948
Crebl2 Mus musculus ENSMUSG00000032652 I 0.948
ENSNLEG00000003583 Nomascus leucogenys ENSNLEG00000003583 I 0.948
CREBL2 Ornithorhynchus anatinus ENSOANG00000000735 I 0.948
ENSOARG00000020855 Ovis aries ENSOARG00000020855 I 0.948
CREBL2 Oryctolagus cuniculus ENSOCUG00000016255 I 0.948
CREBL2 Otolemur garnettii ENSOGAG00000030941 I 0.948
ENSONIG00000007545 Oreochromis niloticus ENSONIG00000007545 I 0.948
CREBL2 Ochotona princeps ENSOPRG00000014420 I 0.948
crebl2 Oryzias latipes ENSORLG00000020771 I 0.948
ENSP00000228865-D1 Bos grunniens ENSP00000228865-D1 I 0.948
ENSPANG00000004278 Papio anubis ENSPANG00000004278 I 0.948
ENSPCAG00000009944 Procavia capensis ENSPCAG00000009944 I 0.877
ENSPFOG00000001885 Poecilia formosa ENSPFOG00000001885 I 0.948
ENSPPYG00000004305 Pongo abelii ENSPPYG00000004305 I 0.948
ENSPSIG00000009401 Pelodiscus sinensis ENSPSIG00000009401 I 0.948
CREBL2 Pan troglodytes ENSPTRG00000004705 I 0.948
CREBL2 Pteropus vampyrus ENSPVAG00000002635 I 0.948
Crebl2 Rattus norvegicus ENSRNOG00000007115 I 0.948
ENSSARG00000000399 Sorex araneus ENSSARG00000000399 I 0.932
ENSSHAG00000012055 Sarcophilus harrisii ENSSHAG00000012055 I 0.932
ENSSTOG00000012351 Ictidomys tridecemlineatus ENSSTOG00000012351 I 0.948
CREBL2 Tupaia belangeri ENSTBEG00000010710 I 0.948
CREBL2 Taeniopygia guttata ENSTGUG00000012705 I 0.929
crebl2 Tetraodon nigroviridis ENSTNIG00000003356 I 0.948
crebl2 Takifugu rubripes ENSTRUG00000003298 I 0.948
CREBL2 Tursiops truncatus ENSTTRG00000015032 I 0.948
CREBL2 Vicugna pacos ENSVPAG00000004644 I 0.948
ENSXMAG00000002733 Xiphophorus maculatus ENSXMAG00000002733 I 0.948
e_gw.578.19.1 Branchiostoma floridae e_gw.578.19.1 I 0.845
CG18619 Drosophila melanogaster FBgn0032202 D 0.872
GA15016 Drosophila pseudoobscura FBgn0075041 I 0.859
GF15758 Drosophila ananassae FBgn0092782 I 0.869
GG10098 Drosophila erecta FBgn0102410 I 0.867
GH13018 Drosophila grimshawi FBgn0120496 I 0.874
GI18265 Drosophila mojavensis FBgn0141004 I 0.888
GL19008 Drosophila persimilis FBgn0156609 I 0.859
GM18070 Drosophila sechellia FBgn0172977 I 0.869
GD23670 Drosophila simulans FBgn0195047 I 0.869
GJ17525 Drosophila virilis FBgn0204695 I 0.859
GK23539 Drosophila willistoni FBgn0225501 I 0.826
GE18912 Drosophila yakuba FBgn0236286 I 0.858
fgenesh2_pg.scaffold_155000104 Branchiostoma floridae fgenesh2_pg.scaffold_155000104 I 0.845
GB55635 Apis mellifera GB55635 I 0.900
Gfo_R000347 Geospiza fortis Gfo_R000347 I 0.948
HelroG81859 Helobdella robusta HelroG81859 I 0.802
HHAL006354-PA Halyomorpha halys HHAL006354-PA I 0.844
HMEL004784 Heliconius melpomene HMEL004784 I 0.860
ISCW012752 Ixodes scapularis ISCW012752 I 0.878
KGM_09246 Danaus plexippus KGM_09246 I 0.860
L798_15162 Zootermopsis nevadensis L798_15162 I 0.869
LCUP013291 Lucilia cuprina LCUP013291 I 0.895
LDEC012948 Leptinotarsa decemlineata LDEC012948 I 0.831
LLOJ001356 Lutzomyia longipalpis LLOJ001356 I 0.882
LotgiG59424 Lottia gigantea LotgiG59424 I 0.894
MCINX001206 Melitaea cinxia MCINX001206 I 0.805
MDOA012994 Musca domestica MDOA012994 I 0.872
MDOA014401 Musca domestica MDOA014401 I 0.868
Myotis_brandtii_CREBL2_10031479 Myotis brandtii Myotis_brandtii_CREBL2_10031479 I 0.948
NEMVEDRAFT_v1g39436 Nematostella vectensis NEMVEDRAFT_v1g39436 I 0.866
NV17690 Nasonia vitripennis NV17690 I 0.821
Ocbimv22011426m.g Octopus bimaculoides Ocbimv22011426m.g I 0.887
PHUM516220 Pediculus humanus PHUM516220 I 0.891
PPAI006023 Phlebotomus papatasi PPAI006023 I 0.880
Pvit_13344 Pogona vitticeps Pvit_13344 I 0.948
RPRC008087 Rhodnius prolixus RPRC008087 I 0.857
Sakowv30009524m.g Saccoglossus kowalevskii Sakowv30009524m.g I 0.855
SMAR010609 Strigamia maritima SMAR010609 I 0.842
Tal_R009035 Tyto alba Tal_R009035 I 0.948
TC012882 Tribolium castaneum TC012882 I 0.897
tetur01g05560 Tetranychus urticae tetur01g05560 I 0.899
crebl2 Xenopus tropicalis XB-GENE-940117 I 0.948
YQE_12440 Dendroctonus ponderosae YQE_12440 I 0.870