ENSP00000356919 (Macaca fascicularis)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00170 (bZIP_1) IPR011616 ENSP00000356919 T070184_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ATF6
M04254_2.00
Homo sapiens
YKRTGACGTGGCAN

NTGCCACGTCAYMR
SELEX
Yin et al.(2017)
ATF6_eDBD_HT-SELEX_1
0.885 1.000
ATF6
M04255_2.00
Homo sapiens
NRTGACGTCAYN

NRTGACGTCAYN
SELEX
Yin et al.(2017)
ATF6_eDBD_HT-SELEX_2
0.885 1.000
ATF6
M04018_2.00
Homo sapiens
GRTGACGTGGCR

YGCCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
ATF6.1
0.885 1.000
ATF6
M04019_2.00
Homo sapiens
KAGTCACGTGK

MCACGTGACTM
SELEX
Rodriguez-Martinez et al.(2017)
ATF6.2
0.885 1.000
ATF6
M04020_2.00
Homo sapiens
BNRTGACGTCATCA

TGATGACGTCAYNV
SELEX
Rodriguez-Martinez et al.(2017)
ATF6.3
0.885 1.000
ATF6
M04021_2.00
Homo sapiens
ACCACGATGTY

RACATCGTGGT
SELEX
Rodriguez-Martinez et al.(2017)
ATF6.4
0.885 1.000
ATF6
M08790_2.00
Homo sapiens
VBSSTGACGTGG

CCACGTCASSVB
Misc
Kulakovskiy et al.(2013)
ATF6A_HUMAN.H11MO.0.B
0.885 1.000
ATF6
M09947_2.00
Homo sapiens
TGACGTGG

CCACGTCA
Transfac
Matys et al.(2006)
V$ATF6_01
0.885 1.000
ATF6
M04256_2.00
Homo sapiens
YGRTGACGTGGCRN

NYGCCACGTCAYCR
SELEX
Yin et al.(2017)
ATF6_eDBD_Methyl-HT-SELEX_1
0.885 1.000
ATF6
M04257_2.00
Homo sapiens
NRTGACGTCAYN

NRTGACGTCAYN
SELEX
Yin et al.(2017)
ATF6_eDBD_Methyl-HT-SELEX_2
0.885 1.000
ATF6B
M04375_2.00
Homo sapiens
NRTGACGTCAYN

NRTGACGTCAYN
SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_1
0.832 0.635
ATF6B
M04376_2.00
Homo sapiens
NRTGACGTGGCR

YGCCACGTCAYN
SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_2
0.832 0.635
ATF6B
M04377_2.00
Homo sapiens
TGCCACGTGGCR

YGCCACGTGGCA
SELEX
Yin et al.(2017)
ATF6B_eDBD_HT-SELEX_3
0.832 0.635
ATF6B
M04041_2.00
Homo sapiens
GRTGACGTGGCR

YGCCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.1
0.832 0.635
ATF6B
M04042_2.00
Homo sapiens
YGMCACGTGKCR

YGMCACGTGKCR
SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.2
0.832 0.635
ATF6B
M04043_2.00
Homo sapiens
RTGACGTCAYC

GRTGACGTCAY
SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.3
0.832 0.635
ATF6B
M04044_2.00
Homo sapiens
MCCACGATGT

ACATCGTGGK
SELEX
Rodriguez-Martinez et al.(2017)
ATF6B.4
0.832 0.635
ATF6B
M04378_2.00
Homo sapiens
SRTGACGTCAYB

VRTGACGTCAYS
SELEX
Yin et al.(2017)
ATF6B_eDBD_Methyl-HT-SELEX_1
0.832 0.635
ATF6B
M04379_2.00
Homo sapiens
BRTGACGTGGCR

YGCCACGTCAYV
SELEX
Yin et al.(2017)
ATF6B_eDBD_Methyl-HT-SELEX_2
0.832 0.635
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356919 bZIP 305 367

Links

Other bZIP family TFs
Other Macaca fascicularis TFs

111 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Atf6 Rattus norvegicus ENSRNOG00000024632 I 0.885
ENSPANG00000021910 Papio anubis ENSPANG00000021910 I 0.885
ENSPPYG00000000589 Pongo abelii ENSPPYG00000000589 I 0.885
ENSCSAG00000002721 Chlorocebus sabaeus ENSCSAG00000002721 I 0.885
ATF6 Pan troglodytes ENSPTRG00000001596 I 0.885
ATF6 Callithrix jacchus ENSCJAG00000004572 I 0.885
ATF6 Otolemur garnettii ENSOGAG00000001917 I 0.885
ATF6 Oryctolagus cuniculus ENSOCUG00000007930 I 0.885
ENSTSYG00000002035 Tarsius syrichta ENSTSYG00000002035 I 0.885
Atf6 Mus musculus ENSMUSG00000026663 I 0.885
ENSNLEG00000014528 Nomascus leucogenys ENSNLEG00000014528 I 0.885
ATF6 Macaca mulatta ENSMMUG00000004049 I 0.885
ATF6 Homo sapiens ENSG00000118217 D 0.885
ATF6 Cavia porcellus ENSCPOG00000010325 I 0.885
ENSPSIG00000016522 Pelodiscus sinensis ENSPSIG00000016522 I 0.882
ATF6 Gorilla gorilla ENSGGOG00000013807 I 0.874
ATF6 Monodelphis domestica ENSMODG00000000980 I 0.869
ATF6 Felis catus ENSFCAG00000023651 I 0.869
ATF6 Echinops telfairi ENSETEG00000004183 I 0.869
ENSOARG00000010418 Ovis aries ENSOARG00000010418 I 0.869
ATF6 Sus scrofa ENSSSCG00000006346 I 0.869
ENSMPUG00000003493 Mustela putorius furo ENSMPUG00000003493 I 0.869
ATF6 Loxodonta africana ENSLAFG00000003622 I 0.869
ENSSHAG00000005867 Sarcophilus harrisii ENSSHAG00000005867 I 0.869
ATF6 Erinaceus europaeus ENSEEUG00000000007 I 0.869
ATF6 Canis familiaris ENSCAFG00000013068 I 0.869
ATF6 Equus caballus ENSECAG00000022307 I 0.869
ENSP00000356919-D1 Bos grunniens ENSP00000356919-D1 I 0.869
ATF6 Bos taurus ENSBTAG00000005227 I 0.869
ENSAMEG00000001631 Ailuropoda melanoleuca ENSAMEG00000001631 I 0.869
Alligator_sinensis_CCG016908.1 Alligator sinensis Alligator_sinensis_CCG016908.1 I 0.869
ATF6 Choloepus hoffmanni ENSCHOG00000009031 I 0.869
ATF6 Tursiops truncatus ENSTTRG00000008508 I 0.869
ENSDNOG00000008226 Dasypus novemcinctus ENSDNOG00000008226 I 0.869
ATF6 Vicugna pacos ENSVPAG00000004732 I 0.869
atf6.S Xenopus laevis XB-GENE-983817 I 0.867
atf6 Xenopus tropicalis XB-GENE-983814 I 0.867
ATF6 Meleagris gallopavo ENSMGAG00000005185 I 0.866
Gfo_R012350 Geospiza fortis Gfo_R012350 I 0.866
ENSAPLG00000013950 Anas platyrhynchos ENSAPLG00000013950 I 0.866
Brh_R005562 Buceros rhinoceros Brh_R005562 I 0.866
Aan_R002718 Calypte anna Aan_R002718 I 0.866
Afo_R000376 Aptenodytes forsteri Afo_R000376 I 0.866
ENSFALG00000003490 Ficedula albicollis ENSFALG00000003490 I 0.866
ATF6 Taeniopygia guttata ENSTGUG00000017057 I 0.866
ENSGALG00000002658 Gallus gallus ENSGALG00000002658 I 0.866
ATF6 Tupaia belangeri ENSTBEG00000015845 I 0.861
ATF6 Microcebus murinus ENSMICG00000000038 I 0.861
Myotis_brandtii_ATF6_10024274 Myotis brandtii Myotis_brandtii_ATF6_10024274 I 0.858
ATF6 Ornithorhynchus anatinus ENSOANG00000009735 I 0.853
ENSMEUG00000008122 Macropus eugenii ENSMEUG00000008122 I 0.845
Pvit_17701 Pogona vitticeps Pvit_17701 I 0.845
ENSAMXG00000010343 Astyanax mexicanus ENSAMXG00000010343 I 0.842
Pvit_13420 Pogona vitticeps Pvit_13420 I 0.840
ENSSHAG00000010010 Sarcophilus harrisii ENSSHAG00000010010 I 0.839
atf6 Danio rerio ENSDARG00000012656 I 0.835
ENSPMAG00000007037 Petromyzon marinus ENSPMAG00000007037 I 0.834
ATF6B Felis catus ENSFCAG00000018408 I 0.832
ATF6B Equus caballus ENSECAG00000021507 I 0.832
ENSSTOG00000027684 Ictidomys tridecemlineatus ENSSTOG00000027684 I 0.832
ENSMPUG00000010305 Mustela putorius furo ENSMPUG00000010305 I 0.832
ATF6B Gorilla gorilla ENSGGOG00000004870 I 0.832
ENSAMEG00000002381 Ailuropoda melanoleuca ENSAMEG00000002381 I 0.832
ATF6B Sus scrofa ENSSSCG00000001430 I 0.832
Atf6b Dipodomys ordii ENSDORG00000004227 I 0.832
ENSTSYG00000003325 Tarsius syrichta ENSTSYG00000003325 I 0.832
ATF6B Callithrix jacchus ENSCJAG00000036009 I 0.832
ATF6B Canis familiaris ENSCAFG00000000761 I 0.832
ENSP00000364349 Macaca fascicularis ENSP00000364349 I 0.832
ATF6B Cavia porcellus ENSCPOG00000023551 I 0.832
ENSCSAG00000009237 Chlorocebus sabaeus ENSCSAG00000009237 I 0.832
ATF6B Tursiops truncatus ENSTTRG00000005958 I 0.832
ATF6B Dasypus novemcinctus ENSDNOG00000042135 I 0.832
Atf6b Rattus norvegicus ENSRNOG00000000431 I 0.832
ATF6B Bos taurus ENSBTAG00000008794 I 0.832
ATF6B Homo sapiens ENSG00000213676 D 0.832
ATF6B Pteropus vampyrus ENSPVAG00000005144 I 0.832
ATF6B Ochotona princeps ENSOPRG00000019053 I 0.832
ATF6B Macaca mulatta ENSMMUG00000015229 I 0.832
ATF6B Otolemur garnettii ENSOGAG00000032721 I 0.832
ENSLOCG00000001278 Lepisosteus oculatus ENSLOCG00000001278 I 0.832
ENSNLEG00000006562 Nomascus leucogenys ENSNLEG00000006562 I 0.832
ATF6B Oryctolagus cuniculus ENSOCUG00000023089 I 0.832
ENSPANG00000006897 Papio anubis ENSPANG00000006897 I 0.832
ATF6B Monodelphis domestica ENSMODG00000014920 I 0.832
ENSPPYG00000016479 Pongo abelii ENSPPYG00000016479 I 0.832
Atf6b Mus musculus ENSMUSG00000015461 I 0.832
Ogr11447 Ophisaurus gracilis Ogr11447 I 0.831
Alligator_sinensis_CCG007030.1 Alligator sinensis Alligator_sinensis_CCG007030.1 I 0.831
CapteG216503 Capitella teleta CapteG216503 I 0.830
ATF6B Anolis carolinensis ENSACAG00000010535 I 0.830
ATF6B Pan troglodytes ENSPTRG00000034357 I 0.830
Ogr01669 Ophisaurus gracilis Ogr01669 I 0.827
ATF6B Loxodonta africana ENSLAFG00000020739 I 0.820
ATF6B Procavia capensis ENSPCAG00000009251 I 0.820
atf6 Takifugu rubripes ENSTRUG00000006660 I 0.818
ENSGMOG00000018033 Gadus morhua ENSGMOG00000018033 I 0.816
ATF6B Myotis lucifugus ENSMLUG00000026641 I 0.814
Myotis_brandtii_ATF6B_10007217 Myotis brandtii Myotis_brandtii_ATF6B_10007217 I 0.814
ATF6 Anolis carolinensis ENSACAG00000001336 I 0.814
atf6 Gasterosteus aculeatus ENSGACG00000011702 I 0.811
ENSONIG00000002137 Oreochromis niloticus ENSONIG00000002137 I 0.810
atf6 Oryzias latipes ENSORLG00000016676 I 0.810
Tal_R013420 Tyto alba Tal_R013420 I 0.809
L798_08597 Zootermopsis nevadensis L798_08597 I 0.800
ENSPFOG00000018418 Poecilia formosa ENSPFOG00000018418 I 0.794
ENSXMAG00000013231 Xiphophorus maculatus ENSXMAG00000013231 I 0.794
ENSBTAP00000042742-D1 Bos grunniens ENSBTAP00000042742-D1 I 0.788
ENSLACG00000012831 Latimeria chalumnae ENSLACG00000012831 I 0.786
ENSLACG00000007649 Latimeria chalumnae ENSLACG00000007649 I 0.784
SMAR005991 Strigamia maritima SMAR005991 I 0.783