ATF7 (Homo sapiens)
bZIP,C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1)
PF00096 (zf-C2H2) 		IPR011616
IPR007087 		ENSG00000170653 T075500_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ATF7
M02872_2.00		 Homo sapiens
NDRTGACGTCATNN
NNATGACGTCAYHN		 SELEX
Jolma et al.(2013)
ATF7_1		 (Direct) (Direct)
ATF7
M04382_2.00		 Homo sapiens
NRTGACGTCAYN
NRTGACGTCAYN		 SELEX
Yin et al.(2017)
ATF7_eDBD_HT-SELEX		 (Direct) (Direct)
ATF7
M04383_2.00		 Homo sapiens
NRTKAYGTMATN
NATKACRTMAYN		 SELEX
Yin et al.(2017)
ATF7_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Atf7
M09499_2.00 		Mus musculus
NNVTGACRTCAB
VTGAYGTCABNN		 Misc
Heinz et al.(2010)
3T3L1-Atf7_GSE56872 		0.989 0.989
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000387406 C2H2 ZF 7 31
ENSP00000387406 bZIP 330 393
ENSP00000399465 C2H2 ZF 7 31
ENSP00000399465 bZIP 330 393
ENSP00000449938 C2H2 ZF 7 31
ENSP00000449938 bZIP 341 404
ENSP00000456858 C2H2 ZF 7 31
ENSP00000465192 C2H2 ZF 7 31
ENSP00000468623 C2H2 ZF 7 31

Links

Other bZIP,C2H2 ZF family TFs
Other Homo sapiens TFs

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78 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action