Zeb1 (Mus musculus)
C2H2 ZF,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2)
PF00046 (Homeobox) 		IPR007087
IPR001356 		ENSMUSG00000024238 T075918_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; regulation of T cell differentiation in thymus; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; embryo mesoderm; and genitourinary system. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zeb1
M05844_2.00		 Mus musculus
NYACCTGN
NCAGGTRN		 SMiLE-seq
Isakova et al.(2017)
ZEB1		 (Direct) (Direct)
Zeb1
M08849_2.00		 Mus musculus
YHYACCTGBV
BVCAGGTRDR		 Misc
Kulakovskiy et al.(2013)
ZEB1_MOUSE.H11MO.0.B		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZEB1
M08080_2.00 		Homo sapiens
NNCACCTGBNN
NNVCAGGTGNN		 ChIP-seq
Mathelier et al.(2014)
MA0103.3 		0.986 0.986
ZEB1
M07842_2.00 		Homo sapiens
YNCACCTG
CAGGTGNR		 ChIP-seq
Gerstein et al.(2012)
GM12878_ZEB1_HudsonAlpha 		0.986 0.986
ZEB1
M08190_2.00 		Homo sapiens
CVCWCACCTG
CAGGTGWGBG		 ChIP-seq
Contrino et al.(2012)
Mv136 		0.986 0.986
ZEB1
M08848_2.00 		Homo sapiens
YHYACCTGBV
BVCAGGTRDR		 Misc
Kulakovskiy et al.(2013)
ZEB1_HUMAN.H11MO.0.A 		0.986 0.986
ZEB1
M10089_2.00 		Homo sapiens
NHYDYACCTGWVY
RBWCAGGTRHRDN		 Transfac
Matys et al.(2006)
V$AREB6_01 		0.986 0.986
ZEB1
M10090_2.00 		Homo sapiens
WHWCACCTKWNN
NNWMAGGTGWDW		 Transfac
Matys et al.(2006)
V$AREB6_02 		0.986 0.986
ZEB1
M10091_2.00 		Homo sapiens
VBRCACCTGKDV
BHMCAGGTGYVB		 Transfac
Matys et al.(2006)
V$AREB6_03 		0.986 0.986
ZEB1
M10092_2.00 		Homo sapiens
NNSAAACVB
VBGTTTSNN		 Transfac
Matys et al.(2006)
V$AREB6_04 		0.986 0.986
ZEB1
M10093_2.00 		Homo sapiens
NHNCACCTDRV
BYHAGGTGNDN		 Transfac
Matys et al.(2006)
V$DELTAEF1_01 		0.986 0.986
ZEB1
M10094_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZEB1_03 		0.986 0.986
ZEB1
M10095_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZEB_Q3 		0.986 0.986
ZEB2
M10096_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SIP1_Q6 		0.832 0.832
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000025081 C2H2 ZF 150 173
ENSMUSP00000025081 C2H2 ZF 180 202
ENSMUSP00000025081 C2H2 ZF 220 242
ENSMUSP00000025081 C2H2 ZF 248 269
ENSMUSP00000025081 Homeodomain 564 612
ENSMUSP00000025081 C2H2 ZF 882 904
ENSMUSP00000025081 C2H2 ZF 910 932
ENSMUSP00000025081 C2H2 ZF 938 959
ENSMUSP00000124395 C2H2 ZF 96 119
ENSMUSP00000124395 C2H2 ZF 126 148
ENSMUSP00000124395 C2H2 ZF 166 188
ENSMUSP00000124395 C2H2 ZF 194 215
ENSMUSP00000124815 C2H2 ZF 133 154

Links

Other C2H2 ZF,Homeodomain family TFs
Other Mus musculus TFs

128 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Zeb1 Rattus norvegicus ENSRNOG00000017863 I 0.990
Cmyd_10008652 Chelonia mydas Cmyd_10008652 I 0.986
ZEB1 Dasypus novemcinctus ENSDNOG00000016748 I 0.986
ZEB1 Macaca mulatta ENSMMUG00000015453 I 0.986
ENSSTOG00000016404 Ictidomys tridecemlineatus ENSSTOG00000016404 I 0.986
Alligator_sinensis_CCG010397.1 Alligator sinensis Alligator_sinensis_CCG010397.1 I 0.986
ENSCSAG00000011628 Chlorocebus sabaeus ENSCSAG00000011628 I 0.986
Myotis_brandtii_ZEB1_10033015 Myotis brandtii Myotis_brandtii_ZEB1_10033015 I 0.986
ENSP00000319248 Macaca fascicularis ENSP00000319248 I 0.986
ZEB1 Felis catus ENSFCAG00000010440 I 0.986
ZEB1 Gorilla gorilla ENSGGOG00000010090 I 0.986
ZEB1 Loxodonta africana ENSLAFG00000009663 I 0.986
Zeb1 Dipodomys ordii ENSDORG00000007230 I 0.986
ENSMPUG00000013033 Mustela putorius furo ENSMPUG00000013033 I 0.986
ZEB1 Callithrix jacchus ENSCJAG00000013332 I 0.986
ZEB1 Pan troglodytes ENSPTRG00000002404 I 0.986
ZEB1 Otolemur garnettii ENSOGAG00000008365 I 0.986
ENSAMEG00000010224 Ailuropoda melanoleuca ENSAMEG00000010224 I 0.986
ENSPSIG00000009469 Pelodiscus sinensis ENSPSIG00000009469 I 0.986
ENSPANG00000022899 Papio anubis ENSPANG00000022899 I 0.986
ZEB1 Pteropus vampyrus ENSPVAG00000010088 I 0.986
ZEB1 Bos taurus ENSBTAG00000020053 I 0.986
ZEB1 Homo sapiens ENSG00000148516 D 0.986
ENSPPYG00000002189 Pongo abelii ENSPPYG00000002189 I 0.986
ENSNLEG00000018130 Nomascus leucogenys ENSNLEG00000018130 I 0.986
ZEB1 Canis familiaris ENSCAFG00000004023 I 0.986
Afo_R009258 Aptenodytes forsteri Afo_R009258 I 0.981
ZEB1 Monodelphis domestica ENSMODG00000007847 I 0.981
ZEB1 Sorex araneus ENSSARG00000010985 I 0.981
ENSSHAG00000005352 Sarcophilus harrisii ENSSHAG00000005352 I 0.981
ZEB1 Meleagris gallopavo ENSMGAG00000006355 I 0.981
Aan_R013683 Calypte anna Aan_R013683 I 0.981
ZEB1 Gallus gallus ENSGALG00000007260 I 0.981
Gfo_R014876 Geospiza fortis Gfo_R014876 I 0.981
Tal_R009077 Tyto alba Tal_R009077 I 0.981
ENSFALG00000007118 Ficedula albicollis ENSFALG00000007118 I 0.981
ENSAPLG00000007482 Anas platyrhynchos ENSAPLG00000007482 I 0.981
ENSLACG00000013253 Latimeria chalumnae ENSLACG00000013253 I 0.976
ZEB1 Anolis carolinensis ENSACAG00000007353 I 0.971
ZEB1 Taeniopygia guttata ENSTGUG00000001020 I 0.971
zeb1 Xenopus tropicalis XB-GENE-484655 I 0.966
zeb1.S Xenopus laevis XB-GENE-865109 I 0.961
ABC48601 Xenopus laevis ABC48601 I 0.956
ENSLOCG00000007239 Lepisosteus oculatus ENSLOCG00000007239 I 0.952
zeb1b Danio rerio ENSDARG00000013207 I 0.908
ENSONIG00000003766 Oreochromis niloticus ENSONIG00000003766 I 0.882
zeb1b Oryzias latipes ENSORLG00000004296 I 0.874
ENSPFOG00000013823 Poecilia formosa ENSPFOG00000013823 I 0.865
zeb1b Gasterosteus aculeatus ENSGACG00000001002 I 0.865
ZEB1 Cavia porcellus ENSCPOG00000007682 I 0.861
ZEB1 Myotis lucifugus ENSMLUG00000010631 I 0.861
ENSXMAG00000005475 Xiphophorus maculatus ENSXMAG00000005475 I 0.859
ZEB1 Sus scrofa ENSSSCG00000011025 N 0.827
ZEB1 Echinops telfairi ENSETEG00000011673 N 0.827
ENSBTAP00000053646-D1 Bos grunniens ENSBTAP00000053646-D1 I 0.824
ENSP00000386854 Macaca fascicularis ENSP00000386854 I 0.824
ZEB1 Vicugna pacos ENSVPAG00000001316 N 0.824
Alligator_sinensis_CCG017701.1 Alligator sinensis Alligator_sinensis_CCG017701.1 I 0.824
ENSPPYG00000012831 Pongo abelii ENSPPYG00000012831 I 0.824
ZEB2 Pan troglodytes ENSPTRG00000012513 I 0.824
ZEB2 Vicugna pacos ENSVPAG00000002128 I 0.824
ZEB2 Tursiops truncatus ENSTTRG00000006478 I 0.824
zeb2 Xenopus tropicalis XB-GENE-479558 I 0.824
ENSSHAG00000016692 Sarcophilus harrisii ENSSHAG00000016692 I 0.824
Myotis_brandtii_ZEB2_10007070 Myotis brandtii Myotis_brandtii_ZEB2_10007070 I 0.824
XP_002936763 Xenopus tropicalis XP_002936763 I 0.824
XP_002936766 Xenopus tropicalis XP_002936766 I 0.824
Zeb2 Rattus norvegicus ENSRNOG00000004677 I 0.824
ENSSTOG00000003811 Ictidomys tridecemlineatus ENSSTOG00000003811 I 0.824
ZEB2 Ochotona princeps ENSOPRG00000006205 I 0.824
ZEB2 Myotis lucifugus ENSMLUG00000002019 I 0.824
ENSCSAG00000016197 Chlorocebus sabaeus ENSCSAG00000016197 I 0.824
ZEB2 Macaca mulatta ENSMMUG00000016845 I 0.824
ZEB2 Monodelphis domestica ENSMODG00000003112 I 0.824
ENSGALG00000012440 Gallus gallus ENSGALG00000012440 I 0.824
ZEB2 Dasypus novemcinctus ENSDNOG00000039558 I 0.824
ZEB2 Equus caballus ENSECAG00000019355 I 0.824
ZEB2 Homo sapiens ENSG00000169554 D 0.824
ZEB2 Gorilla gorilla ENSGGOG00000003186 I 0.824
ZEB2 Felis catus ENSFCAG00000015532 I 0.824
ZEB2 Loxodonta africana ENSLAFG00000008960 I 0.824
ZEB2 Meleagris gallopavo ENSMGAG00000012628 I 0.824
Zeb2 Mus musculus ENSMUSG00000026872 I 0.824
ENSMPUG00000003620 Mustela putorius furo ENSMPUG00000003620 I 0.824
ENSNLEG00000009020 Nomascus leucogenys ENSNLEG00000009020 I 0.824
ENSAMEG00000009337 Ailuropoda melanoleuca ENSAMEG00000009337 I 0.824
ENSPANG00000008399 Papio anubis ENSPANG00000008399 I 0.824
ZEB2 Bos taurus ENSBTAG00000012615 I 0.824
ENSAPLG00000007687 Anas platyrhynchos ENSAPLG00000007687 I 0.824
ZEB2 Canis familiaris ENSCAFG00000005497 I 0.824
ZEB2 Callithrix jacchus ENSCJAG00000012457 I 0.824
ZEB2 Cavia porcellus ENSCPOG00000004182 I 0.824
ZEB2 Otolemur garnettii ENSOGAG00000010020 I 0.824
ZEB2 Choloepus hoffmanni ENSCHOG00000001435 I 0.824
ZEB2 Oryctolagus cuniculus ENSOCUG00000027880 I 0.824
Cmyd_10013008 Chelonia mydas Cmyd_10013008 I 0.823
ENSPSIG00000016788 Pelodiscus sinensis ENSPSIG00000016788 I 0.823
Gfo_R001123 Geospiza fortis Gfo_R001123 I 0.819
ENSFALG00000013846 Ficedula albicollis ENSFALG00000013846 I 0.819
Brh_R003547 Buceros rhinoceros Brh_R003547 I 0.819
Aan_R003058 Calypte anna Aan_R003058 I 0.819
ZEB2 Taeniopygia guttata ENSTGUG00000011904 I 0.819
Afo_R000542 Aptenodytes forsteri Afo_R000542 I 0.819
ENSONIG00000015066 Oreochromis niloticus ENSONIG00000015066 I 0.819
ENSPFOG00000014086 Poecilia formosa ENSPFOG00000014086 I 0.819
ENSPFOG00000014121 Poecilia formosa ENSPFOG00000014121 I 0.819
ENSXMAG00000006005 Xiphophorus maculatus ENSXMAG00000006005 I 0.819
zeb1b Takifugu rubripes ENSTRUG00000001422 I 0.816
zeb2.S Xenopus laevis XB-GENE-865280 I 0.814
ZEB2 Anolis carolinensis ENSACAG00000023811 I 0.810
Pvit_13221 Pogona vitticeps Pvit_13221 I 0.810
Ogr14261 Ophisaurus gracilis Ogr14261 I 0.810
zeb1a Tetraodon nigroviridis ENSTNIG00000007962 I 0.808
ENSAMXG00000010069 Astyanax mexicanus ENSAMXG00000010069 I 0.796
ENSGMOG00000010266 Gadus morhua ENSGMOG00000010266 I 0.793
zeb1a Gasterosteus aculeatus ENSGACG00000017648 I 0.785
zeb1a Danio rerio ENSDARG00000016788 I 0.778
ENSOARG00000013971 Ovis aries ENSOARG00000013971 I 0.774
ZEB1 Oryctolagus cuniculus ENSOCUG00000006516 I 0.769
ZEB1 Equus caballus ENSECAG00000020102 I 0.764
ZEB1 Tursiops truncatus ENSTTRG00000011798 I 0.764
ZEB1 Procavia capensis ENSPCAG00000004425 I 0.764
ENSXMAG00000002123 Xiphophorus maculatus ENSXMAG00000002123 I 0.761
Pvit_04101 Pogona vitticeps Pvit_04101 I 0.760
ZEB2 Pteropus vampyrus ENSPVAG00000015557 I 0.760
ZEB1 Erinaceus europaeus ENSEEUG00000006386 I 0.755
ENSPFOG00000016296 Poecilia formosa ENSPFOG00000016296 I 0.749
ENSTSYG00000009177 Tarsius syrichta ENSTSYG00000009177 I 0.731