CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Zeb2
(
Rattus norvegicus
)
C2H2 ZF,Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
PF00046 (Homeobox)
IPR007087
IPR001356
ENSRNOG00000004677
T075998_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Predicted to be located in chromatin; cytosol; and nuclear lumen. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
ZEB2
M10096_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SIP1_Q6
0.786
0.786
ZEB1
M08080_2.00
Homo sapiens
NNCACCTGBNN
NNVCAGGTGNN
ChIP-seq
Mathelier et al.(2014)
MA0103.3
0.829
0.829
ZEB1
M07842_2.00
Homo sapiens
YNCACCTG
CAGGTGNR
ChIP-seq
Gerstein et al.(2012)
GM12878_ZEB1_HudsonAlpha
0.829
0.829
ZEB1
M08190_2.00
Homo sapiens
CVCWCACCTG
CAGGTGWGBG
ChIP-seq
Contrino et al.(2012)
Mv136
0.829
0.829
ZEB1
M08848_2.00
Homo sapiens
YHYACCTGBV
BVCAGGTRDR
Misc
Kulakovskiy et al.(2013)
ZEB1_HUMAN.H11MO.0.A
0.829
0.829
ZEB1
M10089_2.00
Homo sapiens
NHYDYACCTGWVY
RBWCAGGTRHRDN
Transfac
Matys et al.(2006)
V$AREB6_01
0.829
0.829
ZEB1
M10090_2.00
Homo sapiens
WHWCACCTKWNN
NNWMAGGTGWDW
Transfac
Matys et al.(2006)
V$AREB6_02
0.829
0.829
ZEB1
M10091_2.00
Homo sapiens
VBRCACCTGKDV
BHMCAGGTGYVB
Transfac
Matys et al.(2006)
V$AREB6_03
0.829
0.829
ZEB1
M10092_2.00
Homo sapiens
NNSAAACVB
VBGTTTSNN
Transfac
Matys et al.(2006)
V$AREB6_04
0.829
0.829
ZEB1
M10093_2.00
Homo sapiens
NHNCACCTDRV
BYHAGGTGNDN
Transfac
Matys et al.(2006)
V$DELTAEF1_01
0.829
0.829
ZEB1
M10094_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZEB1_03
0.829
0.829
ZEB1
M10095_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZEB_Q3
0.829
0.829
Zeb1
M05844_2.00
Mus musculus
NYACCTGN
NCAGGTRN
SMiLE-seq
Isakova et al.(2017)
ZEB1
0.824
0.824
Zeb1
M08849_2.00
Mus musculus
YHYACCTGBV
BVCAGGTRDR
Misc
Kulakovskiy et al.(2013)
ZEB1_MOUSE.H11MO.0.B
0.824
0.824
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000006350
C2H2 ZF
211
234
LTCPYCDRGYKRLTSLKEHIKYRH
ENSRNOP00000006350
C2H2 ZF
241
263
FSCPLCSYTFAYRTQLERHMVTH
ENSRNOP00000006350
C2H2 ZF
282
304
FKCTECGKAFKYKHHLKEHLRIH
ENSRNOP00000006350
C2H2 ZF
310
331
YECPNCKKRFSHSGSYSSHISS
ENSRNOP00000006350
Homeodomain
649
699
INPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQ
ENSRNOP00000006350
C2H2 ZF
999
1021
YACDLCDKTFQKSSSLLRHKYEH
ENSRNOP00000006350
C2H2 ZF
1027
1049
HQCQICKKAFKHKHHLIEHSRLH
ENSRNOP00000006350
C2H2 ZF
1055
1076
YQCDKCGKRFSHSGSYSQHMNH
ENSRNOP00000072515
C2H2 ZF
211
234
LTCPYCDRGYKRLTSLKEHIKYRH
ENSRNOP00000072515
C2H2 ZF
241
263
FSCPLCSYTFAYRTQLERHMVTH
ENSRNOP00000072515
C2H2 ZF
282
304
FKCTECGKAFKYKHHLKEHLRIH
ENSRNOP00000072515
C2H2 ZF
310
331
YECPNCKKRFSHSGSYSSHISS
ENSRNOP00000072515
Homeodomain
649
699
INPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQ
ENSRNOP00000072515
C2H2 ZF
999
1021
YACDLCDKTFQKSSSLLRHKYEH
ENSRNOP00000072515
C2H2 ZF
1027
1049
HQCQICKKAFKHKHHLIEHSRLH
ENSRNOP00000072515
C2H2 ZF
1055
1076
YQCDKCGKRFSHSGSYSQHMNH
ENSRNOP00000074730
C2H2 ZF
211
234
LTCPYCDRGYKRLTSLKEHIKYRH
ENSRNOP00000074730
C2H2 ZF
241
263
FSCPLCSYTFAYRTQLERHMVTH
ENSRNOP00000074730
C2H2 ZF
282
304
FKCTECGKAFKYKHHLKEHLRIH
ENSRNOP00000074730
C2H2 ZF
310
331
YECPNCKKRFSHSGSYSSHISS
ENSRNOP00000074730
Homeodomain
649
699
INPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQ
ENSRNOP00000074730
C2H2 ZF
999
1021
YACDLCDKTFQKSSSLLRHKYEH
Links
Other
C2H2 ZF,Homeodomain
family TFs
Other
Rattus norvegicus
TFs
131 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy