zag-1 (Caenorhabditis elegans)
C2H2 ZF,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2)
PF00046 (Homeobox) 		IPR007087
IPR001356 		WBGene00006970 T076201_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in axon guidance; positive regulation of axon extension; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including enteric muscle; intestine; neurons; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Hirschsprung's disease; Mowat-Wilson syndrome; and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1) and ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
F28F9.1 C2H2 ZF 24 46
F28F9.1 C2H2 ZF 52 73
F28F9.1 Homeodomain 224 280
F28F9.1 C2H2 ZF 481 503
F28F9.1 C2H2 ZF 509 531
F28F9.1 C2H2 ZF 537 558

Links

Other C2H2 ZF,Homeodomain family TFs
Other Caenorhabditis elegans TFs

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35 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action