ENSP00000268489 (Macaca fascicularis)
C2H2 ZF,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2)
PF00046 (Homeobox)
IPR007087
IPR001356
ENSP00000268489 T076234_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZFHX3
M10088_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AFP1_Q6
0.998 0.998
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000268489 C2H2 ZF 663 686
ENSP00000268489 C2H2 ZF 718 742
ENSP00000268489 C2H2 ZF 792 816
ENSP00000268489 C2H2 ZF 1076 1100
ENSP00000268489 C2H2 ZF 1357 1382
ENSP00000268489 C2H2 ZF 1398 1420
ENSP00000268489 C2H2 ZF 1426 1449
ENSP00000268489 C2H2 ZF 1542 1566
ENSP00000268489 C2H2 ZF 1593 1617
ENSP00000268489 Homeodomain 2138 2194
ENSP00000268489 Homeodomain 2235 2291
ENSP00000268489 C2H2 ZF 2320 2341
ENSP00000268489 C2H2 ZF 2522 2544
ENSP00000268489 Homeodomain 2634 2690
ENSP00000268489 C2H2 ZF 2704 2726
ENSP00000268489 Homeodomain 2939 2995

Links

Other C2H2 ZF,Homeodomain family TFs
Other Macaca fascicularis TFs

114 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZFHX3 Macaca mulatta ENSMMUG00000021041 I 1.000
ZFHX3 Dasypus novemcinctus ENSDNOG00000046047 I 1.000
ZFHX3 Microcebus murinus ENSMICG00000003537 I 1.000
ENSCSAG00000004171 Chlorocebus sabaeus ENSCSAG00000004171 I 1.000
ZFHX3 Cavia porcellus ENSCPOG00000009111 I 1.000
ZFHX3 Ornithorhynchus anatinus ENSOANG00000005084 I 1.000
ZFHX3 Echinops telfairi ENSETEG00000014223 I 1.000
ENSOCUG00000017910 Oryctolagus cuniculus ENSOCUG00000017910 I 1.000
ENSPPYG00000007513 Pongo abelii ENSPPYG00000007513 I 1.000
ENSPANG00000010456 Papio anubis ENSPANG00000010456 I 1.000
ZFHX3 Gallus gallus ENSGALG00000000713 I 0.998
ZFHX3 Felis catus ENSFCAG00000023839 I 0.998
ZFHX3 Homo sapiens ENSG00000140836 D 0.998
ZFHX3 Myotis lucifugus ENSMLUG00000016100 I 0.998
Zfhx3 Rattus norvegicus ENSRNOG00000014452 I 0.998
ZFHX3 Pan troglodytes ENSPTRG00000008340 I 0.998
ENSMPUG00000007747 Mustela putorius furo ENSMPUG00000007747 I 0.998
ZFHX3 Loxodonta africana ENSLAFG00000017476 I 0.998
ZFHX3 Gorilla gorilla ENSGGOG00000012083 I 0.998
Zfhx3 Mus musculus ENSMUSG00000038872 I 0.998
ENSAMEG00000002197 Ailuropoda melanoleuca ENSAMEG00000002197 I 0.998
ZFHX3 Canis familiaris ENSCAFG00000020243 I 0.996
ZFHX3 Equus caballus ENSECAG00000022984 I 0.996
ENSBTAP00000019489-D1 Bos grunniens ENSBTAP00000019489-D1 I 0.994
ZFHX3 Monodelphis domestica ENSMODG00000002600 I 0.994
zfhx3 Xenopus tropicalis XB-GENE-853731 I 0.994
ENSSHAG00000014394 Sarcophilus harrisii ENSSHAG00000014394 I 0.994
ENSOARG00000003669 Ovis aries ENSOARG00000003669 I 0.994
ZFHX3 Bos taurus ENSBTAG00000014636 I 0.994
ZFHX3 Taeniopygia guttata ENSTGUG00000008190 I 0.992
ENSFALG00000002706 Ficedula albicollis ENSFALG00000002706 I 0.988
ENSLACG00000015046 Latimeria chalumnae ENSLACG00000015046 I 0.984
Pvit_16272 Pogona vitticeps Pvit_16272 I 0.982
ENSLOCG00000004206 Lepisosteus oculatus ENSLOCG00000004206 I 0.980
zfhx3 Danio rerio ENSDARG00000103057 I 0.980
ENSAMXG00000004340 Astyanax mexicanus ENSAMXG00000004340 I 0.980
zfhx3 Oryzias latipes ENSORLG00000007874 I 0.976
ENSONIG00000005914 Oreochromis niloticus ENSONIG00000005914 I 0.970
ENSPFOG00000001702 Poecilia formosa ENSPFOG00000001702 I 0.968
ENSGMOG00000002909 Gadus morhua ENSGMOG00000002909 I 0.966
zfhx3 Takifugu rubripes ENSTRUG00000017601 I 0.964
Gfo_R000560 Geospiza fortis Gfo_R000560 I 0.918
ZFHX3 Erinaceus europaeus ENSEEUG00000008705 I 0.904
ENSPSIG00000003765 Pelodiscus sinensis ENSPSIG00000003765 I 0.878
ENSP00000382394-D1 Bos grunniens ENSP00000382394-D1 I 0.876
Zfhx3 Dipodomys ordii ENSDORG00000016147 I 0.876
ZFHX4 Otolemur garnettii ENSOGAG00000000486 I 0.876
ZFHX3 Callithrix jacchus ENSCJAG00000015112 I 0.876
ZFHX4 Pteropus vampyrus ENSPVAG00000004200 I 0.876
ENSMPUG00000010092 Mustela putorius furo ENSMPUG00000010092 I 0.876
ENSOARG00000007353 Ovis aries ENSOARG00000007353 I 0.876
ZFHX4 Canis familiaris ENSCAFG00000008310 I 0.876
ZFHX4 Bos taurus ENSBTAG00000033268 I 0.876
ZFHX4 Felis catus ENSFCAG00000015688 I 0.876
ZFHX4 Equus caballus ENSECAG00000022611 I 0.875
ZFHX4 Cavia porcellus ENSCPOG00000012693 I 0.875
ZFHX4 Loxodonta africana ENSLAFG00000014395 I 0.875
ZFHX4 Oryctolagus cuniculus ENSOCUG00000001723 I 0.875
ZFHX4 Callithrix jacchus ENSCJAG00000000517 I 0.875
ZFHX4 Sorex araneus ENSSARG00000001090 I 0.875
ZFHX4 Gorilla gorilla ENSGGOG00000024837 I 0.875
XP_002939633 Xenopus tropicalis XP_002939633 I 0.875
ENSPANG00000023610 Papio anubis ENSPANG00000023610 I 0.873
ENSCSAG00000013465 Chlorocebus sabaeus ENSCSAG00000013465 I 0.873
ZFHX4 Homo sapiens ENSG00000091656 I 0.873
ENSP00000382394 Macaca fascicularis ENSP00000382394 I 0.873
ZFHX4 Tupaia belangeri ENSTBEG00000012567 I 0.873
ZFHX3 Tursiops truncatus ENSTTRG00000002935 I 0.871
ENSAMXG00000013609 Astyanax mexicanus ENSAMXG00000013609 I 0.871
ENSSTOG00000024425 Ictidomys tridecemlineatus ENSSTOG00000024425 I 0.871
zfhx4 Danio rerio ENSDARG00000075542 I 0.869
ZFHX4 Sus scrofa ENSSSCG00000006169 I 0.865
Zfhx4 Rattus norvegicus ENSRNOG00000008765 I 0.865
ZFHX3 Sorex araneus ENSSARG00000011764 I 0.861
ZFHX3 Sus scrofa ENSSSCG00000002752 I 0.857
ZFHX4 Pan troglodytes ENSPTRG00000020358 I 0.856
ZFHX3 Procavia capensis ENSPCAG00000010600 I 0.853
ZFHX3 Anolis carolinensis ENSACAG00000008238 I 0.851
Afo_R007434 Aptenodytes forsteri Afo_R007434 I 0.851
ENSAPLG00000002327 Anas platyrhynchos ENSAPLG00000002327 I 0.851
Aan_R009157 Calypte anna Aan_R009157 I 0.851
ZFHX3 Meleagris gallopavo ENSMGAG00000008764 I 0.850
Ogr16853 Ophisaurus gracilis Ogr16853 I 0.845
ENSAMEG00000016203 Ailuropoda melanoleuca ENSAMEG00000016203 I 0.840
zfhx4 Takifugu rubripes ENSTRUG00000000173 I 0.836
Zfhx4 Mus musculus ENSMUSG00000025255 I 0.830
zfhx4 Gasterosteus aculeatus ENSGACG00000002418 I 0.830
ENSXMAG00000000693 Xiphophorus maculatus ENSXMAG00000000693 I 0.830
ENSPFOG00000009152 Poecilia formosa ENSPFOG00000009152 I 0.830
ENSONIG00000014495 Oreochromis niloticus ENSONIG00000014495 I 0.829
zfhx4 Oryzias latipes ENSORLG00000006928 I 0.829
ZFHX3 Otolemur garnettii ENSOGAG00000010886 I 0.817
Myotis_brandtii_ZFHX3_10022430 Myotis brandtii Myotis_brandtii_ZFHX3_10022430 I 0.817
ENSSTOG00000027206 Ictidomys tridecemlineatus ENSSTOG00000027206 I 0.817
Alligator_sinensis_CCG000692.1 Alligator sinensis Alligator_sinensis_CCG000692.1 I 0.815
zfhx3 Gasterosteus aculeatus ENSGACG00000015779 I 0.795
si:ch73-386h18.1 Danio rerio ENSDARG00000073944 I 0.793
ENSPSIG00000004618 Pelodiscus sinensis ENSPSIG00000004618 I 0.779
ZFHX4 Microcebus murinus ENSMICG00000008252 I 0.777
ENSPPYG00000018687 Pongo abelii ENSPPYG00000018687 I 0.775
ENSSHAG00000013776 Sarcophilus harrisii ENSSHAG00000013776 I 0.765
Aan_R002979 Calypte anna Aan_R002979 I 0.765
ENSFALG00000008584 Ficedula albicollis ENSFALG00000008584 I 0.765
Gfo_R007559 Geospiza fortis Gfo_R007559 I 0.765
ENSGALG00000015673 Gallus gallus ENSGALG00000015673 I 0.765
ZFHX4 Monodelphis domestica ENSMODG00000006777 I 0.765
Tal_R008844 Tyto alba Tal_R008844 I 0.765
Afo_R013178 Aptenodytes forsteri Afo_R013178 I 0.765
Pvit_00058 Pogona vitticeps Pvit_00058 I 0.763
ENSAPLG00000012910 Anas platyrhynchos ENSAPLG00000012910 I 0.763
ENSLOCG00000013472 Lepisosteus oculatus ENSLOCG00000013472 I 0.757
ENSNLEG00000001972 Nomascus leucogenys ENSNLEG00000001972 I 0.711
Cflo_00361--XP_393785.3_APIME Camponotus floridanus Cflo_00361--XP_393785.3_APIME I 0.709
ENSMGAG00000011602 Meleagris gallopavo ENSMGAG00000011602 I 0.705