wt1b (Danio rerio)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSDARG00000007990 T090821_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and macrophage chemotaxis. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
WT1
M00249_2.00 		Homo sapiens
NCYCCCCCVNN
NNBGGGGGRGN		 PBM
Barrera et al.(2016)
WT1_REF 		0.790 0.902
WT1
M08937_2.00 		Homo sapiens
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR		 Misc
Kulakovskiy et al.(2013)
WT1_HUMAN.H11MO.0.C 		0.790 0.902
Wt1
M08968_2.00 		Mus musculus
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR		 Misc
Kulakovskiy et al.(2013)
WT1_MOUSE.H11MO.0.B 		0.790 0.902
Wt1
M10337_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_02 		0.790 0.902
WT1
M10290_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q4 		0.790 0.902
WT1
M10291_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6_01 		0.790 0.902
WT1
M10292_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6_02 		0.790 0.902
WT1
M10293_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$WT1_Q6 		0.790 0.902
WT1
M00244_2.00 		Homo sapiens
NNNWAMWATATN
NATATWKTWNNN		 PBM
Barrera et al.(2016)
WT1_H373Y 		0.790 0.891
WT1
M00245_2.00 		Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_R366C 		0.789 0.891
WT1
M00246_2.00 		Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_R366L 		0.789 0.891
WT1
M00247_2.00 		Homo sapiens
NWATATDAHNN
NNDTHATATWN		 PBM
Barrera et al.(2016)
WT1_R394L 		0.789 0.891
WT1
M00248_2.00 		Homo sapiens
NNTATTWTATNNN
NNNATAWAATANN		 PBM
Barrera et al.(2016)
WT1_R394W 		0.789 0.891
WT1
M00243_2.00 		Homo sapiens
NNNNNNN
NNNNNNN		 PBM
Barrera et al.(2016)
WT1_F392L 		0.783 0.891
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000121364 C2H2 ZF 286 310
ENSDARP00000121364 C2H2 ZF 316 340
ENSDARP00000121364 C2H2 ZF 346 368
ENSDARP00000121364 C2H2 ZF 377 401
ENSDARP00000134684 C2H2 ZF 278 302
ENSDARP00000134684 C2H2 ZF 308 332
ENSDARP00000134684 C2H2 ZF 338 360
ENSDARP00000134684 C2H2 ZF 369 393

Links

Other C2H2 ZF family TFs
Other Danio rerio TFs

76 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
wt1b Gasterosteus aculeatus ENSGACG00000016020 I 0.821
ENSONIG00000005545 Oreochromis niloticus ENSONIG00000005545 I 0.819
wt1 Oryzias latipes ENSORLG00000009859 I 0.816
ENSGMOG00000012296 Gadus morhua ENSGMOG00000012296 I 0.802
WT1 Pan troglodytes ENSPTRG00000003476 I 0.790
Wt1 Rattus norvegicus ENSRNOG00000013074 I 0.790
ENSSHAG00000017390 Sarcophilus harrisii ENSSHAG00000017390 I 0.790
ENSSARG00000000207 Sorex araneus ENSSARG00000000207 I 0.790
ENSPPYG00000029822 Pongo abelii ENSPPYG00000029822 I 0.790
ENSOARG00000016334 Ovis aries ENSOARG00000016334 I 0.790
ENSOANG00000015147 Ornithorhynchus anatinus ENSOANG00000015147 I 0.790
WT1 Otolemur garnettii ENSOGAG00000007118 I 0.790
ENSOPRG00000015709 Ochotona princeps ENSOPRG00000015709 I 0.790
WT1 Sus scrofa ENSSSCG00000013316 I 0.790
ENSPANG00000019482 Papio anubis ENSPANG00000019482 I 0.790
ENSPSIG00000013679 Pelodiscus sinensis ENSPSIG00000013679 I 0.790
ENSSTOG00000023716 Ictidomys tridecemlineatus ENSSTOG00000023716 I 0.790
B5DE03 Xenopus tropicalis B5DE03 I 0.790
Pvit_09510 Pogona vitticeps Pvit_09510 I 0.790
B7ZSG3 Xenopus laevis B7ZSG3 I 0.790
wt1 Xenopus tropicalis XB-GENE-484999 I 0.790
wt1.S Xenopus laevis XB-GENE-864792 I 0.790
wt1.L Xenopus laevis XB-GENE-6252376 I 0.790
Gfo_R001970 Geospiza fortis Gfo_R001970 I 0.790
ENSP00000331327 Macaca fascicularis ENSP00000331327 I 0.790
ENSVPAG00000007788 Vicugna pacos ENSVPAG00000007788 I 0.790
WT1 Taeniopygia guttata ENSTGUG00000004906 I 0.790
Aan_R006616 Calypte anna Aan_R006616 I 0.790
Afo_R014628 Aptenodytes forsteri Afo_R014628 I 0.790
ENSP00000331327-D1 Bos grunniens ENSP00000331327-D1 I 0.790
Alligator_sinensis_CCG012951.1 Alligator sinensis Alligator_sinensis_CCG012951.1 I 0.790
ENSNLEG00000017890 Nomascus leucogenys ENSNLEG00000017890 I 0.790
WT1 Oryctolagus cuniculus ENSOCUG00000005882 I 0.790
Wt1 Dipodomys ordii ENSDORG00000013725 I 0.790
WT1 Dasypus novemcinctus ENSDNOG00000003652 I 0.790
wt1a Danio rerio ENSDARG00000031420 I 0.790
ENSECAG00000022308 Equus caballus ENSECAG00000022308 I 0.790
ENSEEUG00000007221 Erinaceus europaeus ENSEEUG00000007221 I 0.790
Wt1 Mus musculus ENSMUSG00000016458 D 0.790
ENSFALG00000010820 Ficedula albicollis ENSFALG00000010820 I 0.790
WT1 Echinops telfairi ENSETEG00000000684 I 0.790
ENSCSAG00000005257 Chlorocebus sabaeus ENSCSAG00000005257 I 0.790
WT1 Callithrix jacchus ENSCJAG00000005900 I 0.790
ENSAMXG00000013017 Astyanax mexicanus ENSAMXG00000013017 I 0.790
ENSAMEG00000006957 Ailuropoda melanoleuca ENSAMEG00000006957 I 0.790
ENSACAG00000002480 Anolis carolinensis ENSACAG00000002480 I 0.790
ENSAPLG00000005775 Anas platyrhynchos ENSAPLG00000005775 I 0.790
WT1 Bos taurus ENSBTAG00000047268 I 0.790
WT1 Choloepus hoffmanni ENSCHOG00000006244 I 0.790
WT1 Canis familiaris ENSCAFG00000007426 I 0.790
WT1 Homo sapiens ENSG00000184937 D 0.790
WT1 Felis catus ENSFCAG00000000308 I 0.790
WT1 Microcebus murinus ENSMICG00000004097 I 0.790
ENSMGAG00000001489 Meleagris gallopavo ENSMGAG00000001489 I 0.790
WT1 Myotis lucifugus ENSMLUG00000027523 I 0.790
WT1 Macaca mulatta ENSMMUG00000009881 I 0.790
ENSMPUG00000011307 Mustela putorius furo ENSMPUG00000011307 I 0.790
WT1 Monodelphis domestica ENSMODG00000009646 I 0.790
WT1 Gallus gallus ENSGALG00000012115 I 0.790
ENSLOCG00000004537 Lepisosteus oculatus ENSLOCG00000004537 I 0.790
WT1 Loxodonta africana ENSLAFG00000006160 I 0.790
WT1 Gorilla gorilla ENSGGOG00000011586 I 0.790
ENSLACG00000016378 Latimeria chalumnae ENSLACG00000016378 I 0.787
ENSONIG00000011043 Oreochromis niloticus ENSONIG00000011043 I 0.787
WT1 Procavia capensis ENSPCAG00000002213 I 0.787
ENSPMAG00000008950 Petromyzon marinus ENSPMAG00000008950 I 0.784
wt1b Takifugu rubripes ENSTRUG00000006559 I 0.780
ENSPFOG00000017089 Poecilia formosa ENSPFOG00000017089 N 0.780
wt1b Tetraodon nigroviridis ENSTNIG00000013806 I 0.777
wt1 Oryzias latipes ENSORLG00000012424 I 0.775
fgenesh2_pm.scaffold_110000013 Branchiostoma floridae fgenesh2_pm.scaffold_110000013 I 0.770
fgenesh2_pg.scaffold_80000039 Branchiostoma floridae fgenesh2_pg.scaffold_80000039 I 0.770
ENSXMAG00000005139 Xiphophorus maculatus ENSXMAG00000005139 I 0.766
ENSPFOG00000010572 Poecilia formosa ENSPFOG00000010572 I 0.766
Aqu1.215671 Amphimedon queenslandica Aqu1.215671 N 0.760