CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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wt1b
(
Danio rerio
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSDARG00000007990
T090821_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; fin regeneration; and macrophage chemotaxis. Predicted to be located in cytoplasm and nuclear speck. Is expressed in several structures, including eye; heart; intermediate mesoderm; pleuroperitoneal region; and podocyte. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
WT1
M00249_2.00
Homo sapiens
NCYCCCCCVNN
NNBGGGGGRGN
PBM
Barrera et al.(2016)
WT1_REF
0.790
0.902
WT1
M08937_2.00
Homo sapiens
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR
Misc
Kulakovskiy et al.(2013)
WT1_HUMAN.H11MO.0.C
0.790
0.902
Wt1
M08968_2.00
Mus musculus
YYYCBBYYCCTCCYYCNCBY
RVGNGRRGGAGGRRVVGRRR
Misc
Kulakovskiy et al.(2013)
WT1_MOUSE.H11MO.0.B
0.790
0.902
Wt1
M10337_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$WT1_02
0.790
0.902
WT1
M10290_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$WT1_Q4
0.790
0.902
WT1
M10291_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$WT1_Q6_01
0.790
0.902
WT1
M10292_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$WT1_Q6_02
0.790
0.902
WT1
M10293_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$WT1_Q6
0.790
0.902
WT1
M00244_2.00
Homo sapiens
NNNWAMWATATN
NATATWKTWNNN
PBM
Barrera et al.(2016)
WT1_H373Y
0.790
0.891
WT1
M00245_2.00
Homo sapiens
NNNNNNN
NNNNNNN
PBM
Barrera et al.(2016)
WT1_R366C
0.789
0.891
WT1
M00246_2.00
Homo sapiens
NNNNNNN
NNNNNNN
PBM
Barrera et al.(2016)
WT1_R366L
0.789
0.891
WT1
M00247_2.00
Homo sapiens
NWATATDAHNN
NNDTHATATWN
PBM
Barrera et al.(2016)
WT1_R394L
0.789
0.891
WT1
M00248_2.00
Homo sapiens
NNTATTWTATNNN
NNNATAWAATANN
PBM
Barrera et al.(2016)
WT1_R394W
0.789
0.891
WT1
M00243_2.00
Homo sapiens
NNNNNNN
NNNNNNN
PBM
Barrera et al.(2016)
WT1_F392L
0.783
0.891
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000121364
C2H2 ZF
286
310
FVCSYPGCSKRYFKLSHLQMHGRKH
ENSDARP00000121364
C2H2 ZF
316
340
YQCDYTGCGRRFSRSDQLKRHQRRH
ENSDARP00000121364
C2H2 ZF
346
368
FQCETCQRKFSRSDHLKTHTRTH
ENSDARP00000121364
C2H2 ZF
377
401
FTCRWPSCQKKFARSDELVRHHSMH
ENSDARP00000134684
C2H2 ZF
278
302
FVCSYPGCSKRYFKLSHLQMHGRKH
ENSDARP00000134684
C2H2 ZF
308
332
YQCDYTGCGRRFSRSDQLKRHQRRH
ENSDARP00000134684
C2H2 ZF
338
360
FQCETCQRKFSRSDHLKTHTRTH
ENSDARP00000134684
C2H2 ZF
369
393
FTCRWPSCQKKFARSDELVRHHSMH
Links
Other
C2H2 ZF
family TFs
Other
Danio rerio
TFs
76 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy