ikzf1 (Danio rerio)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSDARG00000013539 T090833_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; immune system; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Ikzf1
M08969_2.00 		Mus musculus
HYTCCCAV
BTGGGARD		 Misc
Kulakovskiy et al.(2013)
IKZF1_MOUSE.H11MO.0.C 		0.825 0.989
IKZF1
M08939_2.00 		Homo sapiens
HYTCCCAV
BTGGGARD		 Misc
Kulakovskiy et al.(2013)
IKZF1_HUMAN.H11MO.0.C 		0.825 0.978
IKZF1
M10301_2.00 		Homo sapiens
NHBYGGGAAYRYB
VRYRTTCCCRVDN		 Transfac
Matys et al.(2006)
V$IK1_01 		0.825 0.978
IKZF1
M10302_2.00 		Homo sapiens
BNNWTCCCRNNN
NNNYGGGAWNNV		 Transfac
Matys et al.(2006)
V$IK2_01 		0.825 0.978
IKZF1
M10303_2.00 		Homo sapiens
KNYHGGGAAYRYY
RRYRTTCCCDRNM		 Transfac
Matys et al.(2006)
V$IK3_01 		0.825 0.978
IKZF1
M10304_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IK_Q5_01 		0.825 0.978
IKZF1
M10305_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IK_Q5 		0.825 0.978
IKZF1
M10306_2.00 		Homo sapiens
YYTCCCARA
TYTGGGARR		 Transfac
Matys et al.(2006)
V$LYF1_01 		0.825 0.978
IKZF2
M10105_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HELIOSA_01 		0.804 0.924
IKZF2
M10106_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$HELIOSA_02 		0.804 0.924
IKZF3
M08320_2.00 		Homo sapiens
TTCCCNNSB
VSNNGGGAA		 ChIP-seq
Schmitges et al.(2016)
Q9UKT9_2-4.RCADE 		0.790 0.870
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000013960 C2H2 ZF 123 145
ENSDARP00000013960 C2H2 ZF 162 184
ENSDARP00000013960 C2H2 ZF 190 212
ENSDARP00000013960 C2H2 ZF 218 241
ENSDARP00000046078 C2H2 ZF 59 81
ENSDARP00000046078 C2H2 ZF 87 109
ENSDARP00000046078 C2H2 ZF 115 138
ENSDARP00000050480 C2H2 ZF 59 81
ENSDARP00000050480 C2H2 ZF 87 109
ENSDARP00000050480 C2H2 ZF 115 138
ENSDARP00000074176 C2H2 ZF 123 145
ENSDARP00000074176 C2H2 ZF 151 173
ENSDARP00000074176 C2H2 ZF 179 201
ENSDARP00000074176 C2H2 ZF 207 230

Links

Other C2H2 ZF family TFs
Other Danio rerio TFs

Invalid Input OrderBy

184 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action