| NCBI Gene Info:Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in smoothened signaling pathway and thyroid gland development. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in nucleus. Is expressed in several structures, including brain; endoderm; otic vesicle; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022] |