SHOX (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000185960 T093403_1.02 Ensembl (2011-Oct-26) Link out
NCBI Gene Info:
This gene belongs to the paired homeobox family and is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Defects in this gene are associated with idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. This gene is highly conserved across species from mammals to fish to flies. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
SHOX
M0900_1.02
Homo sapiens
NTAATTRN

NYAATTAN
PBM
Weirauch et al.(2014)
pTH5805
(Direct)
SHOX
M5806_1.02
Homo sapiens
NTAATTRN

NYAATTAN
SELEX
Jolma et al.(2013)
SHOX_1
(Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID DBD
Identity
Shox2
M0967_1.02
Mus musculus
NTAATDDN

NHHATTAN
PBM
Berger et al.(2008)
Shox2_2641
1.000
Shox2
M6082_1.02
Mus musculus
NTAATTRN

NYAATTAN
SELEX
Jolma et al.(2013)
Shox2_1
1.000
Shox2
M3867_1.02
Rattus norvegicus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SHOX2_05
1.000
SHOX2
M5807_1.02
Homo sapiens
BTAATTRN

NYAATTAV
SELEX
Jolma et al.(2013)
SHOX2_1
1.000
SNAPOd2T00006620001
M1154_1.02
Oikopleura dioica
NTAATTRN

NYAATTAN
PBM
Weirauch et al.(2014)
pTH5666
0.842
ARX_RAT
M2964_1.02
Rattus norvegicus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ARX_05
0.737
Arx
M1000_1.02
Mus musculus
NTAATTDN

NHAATTAN
PBM
Berger et al.(2008)
Arx_1738
0.737
Arx
M5986_1.02
Mus musculus
NTAATYNRATTAN

NTAATYNRATTAN
SELEX
Jolma et al.(2013)
Arx_1
0.737
ARX
M5291_1.02
Homo sapiens
NTAATYNRATTAN

NTAATYNRATTAN
SELEX
Jolma et al.(2013)
ARX_1
0.737
hbn
M2034_1.02
Drosophila melanogaster
TTAATTR

YAATTAA
B1H
Mathelier et al.(2014)
MA0226.1
0.719
CG11294
M1981_1.02
Drosophila melanogaster
TTAATTA

TAATTAA
B1H
Mathelier et al.(2014)
MA0172.1
0.719
Uncx
M6108_1.02
Mus musculus
YYAATTAN

NTAATTRR
SELEX
Jolma et al.(2013)
Uncx_2
0.719
UNCX
M1083_1.02
Tetraodon nigroviridis
NNTAATTRN

NYAATTANN
PBM
Weirauch et al.(2014)
pTH5474
0.719
Uncx
M6107_1.02
Mus musculus
NTAATYBAATTAN

NTAATTVRATTAN
SELEX
Jolma et al.(2013)
Uncx_1
0.719
Uncx
M0972_1.02
Mus musculus
NTAATNDN

NHNATTAN
PBM
Berger et al.(2008)
Uncx4
0.719
UNCX
M5942_1.02
Homo sapiens
NTAATTRN

NYAATTAN
SELEX
Jolma et al.(2013)
UNCX_2
0.719
Otp
M0943_1.02
Mus musculus
NNHAATND

HNATTDNN
PBM
Berger et al.(2008)
Otp_3496
0.719
UNCX
M5941_1.02
Homo sapiens
NWDAYBBAATTWN

NWAATTVVRTHWN
SELEX
Jolma et al.(2013)
UNCX_1
0.719
hbn
M5000_1.02
Drosophila melanogaster
NHTAATTR

YAATTADN
B1H
Zhu et al.(2011)
Hbn_SOLEXA_FBgn0008636
0.719
hbn
M4999_1.02
Drosophila melanogaster
YAAWTWA

TWAWTTR
B1H
Zhu et al.(2011)
Hbn_Cell_FBgn0008636
0.719
CG11294
M4807_1.02
Drosophila melanogaster
HTAATTR

YAATTAD
B1H
Zhu et al.(2011)
CG11294_SOLEXA_FBgn0030058
0.719
CG11294
M4806_1.02
Drosophila melanogaster
TTAATTA

TAATTAA
B1H
Zhu et al.(2011)
CG11294_Cell_FBgn0030058
0.719
PHOX2A
M5714_1.02
Homo sapiens
TAAYBYAATTA

TAATTRVRTTA
SELEX
Jolma et al.(2013)
PHOX2A_1
0.702
PHDP
M2260_1.02
Drosophila melanogaster
HTAATTD

HAATTAD
B1H
Mathelier et al.(2014)
MA0457.1
0.702
Pph13
M5161_1.02
Drosophila melanogaster
YTAATTR

YAATTAR
B1H
Zhu et al.(2011)
Pph13_SOLEXA_FBgn0023489
0.702
unc-4
M2057_1.02
Drosophila melanogaster
YTAATTR

YAATTAR
B1H
Mathelier et al.(2014)
MA0250.1
0.702
Pph13
M5160_1.02
Drosophila melanogaster
NHTAATTR

YAATTADN
B1H
Zhu et al.(2011)
Pph13_Cell_FBgn0023489
0.702
otp
M2044_1.02
Drosophila melanogaster
YTAATTA

TAATTAR
B1H
Mathelier et al.(2014)
MA0236.1
0.702
PHDP
M5150_1.02
Drosophila melanogaster
YTAATT

AATTAR
B1H
Zhu et al.(2011)
PhdP_SOLEXA_FBgn0025334
0.702
Pph13
M2009_1.02
Drosophila melanogaster
NTAATTR

YAATTAN
B1H
Mathelier et al.(2014)
MA0200.1
0.702
PHDP
M5149_1.02
Drosophila melanogaster
HTAATT

AATTAD
B1H
Zhu et al.(2011)
PhdP_Cell_FBgn0025334
0.702
Prrx2
M1902_1.02
Mus musculus
TAATT

AATTA
SELEX
Mathelier et al.(2014)
MA0075.1
0.702
PRRX2
M6440_1.02
Homo sapiens
HTAATTR

YAATTAD
HocoMoco
Kulakovskiy et al.(2013)
PRRX2_f1
0.702
otp
M5138_1.02
Drosophila melanogaster
YTAATTR

YAATTAR
B1H
Zhu et al.(2011)
Otp_SOLEXA_FBgn0015524
0.702
Prrx2
M1019_1.02
Mus musculus
WRATNNN

NNNATYW
PBM
Berger et al.(2008)
Prrx2_3072
0.702
Prrx2
M6065_1.02
Mus musculus
NTAATTRN

NYAATTAN
SELEX
Jolma et al.(2013)
Prrx2_1
0.702
otp
M5137_1.02
Drosophila melanogaster
HYTAATTA

TAATTARD
B1H
Zhu et al.(2011)
Otp_Cell_FBgn0015524
0.702
Pax7
M0971_1.02
Mus musculus
NWAATBNN

NNVATTWN
PBM
Berger et al.(2008)
Pax7_3783
0.702
PRRX2
M5757_1.02
Homo sapiens
NTAATTRN

NYAATTAN
SELEX
Jolma et al.(2013)
PRRX2_1
0.702
Prrx2
M3853_1.02
Mus musculus
HNVHTAATTRRNHNDW

WHNDNYYAATTADBND
Transfac
Matys et al.(2006)
V$S8_01
0.702
Phox2b
M0927_1.02
Mus musculus
NNHAAYNN

NNRTTDNN
PBM
Berger et al.(2008)
Phox2b_3948
0.702
PHOX2B
M5716_1.02
Homo sapiens
TAAYBYAATTA

TAATTRVRTTA
SELEX
Jolma et al.(2013)
PHOX2B_2
0.702
PRRX2
M3798_1.02
Sus scrofa Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRX2_Q2
0.702
Phox2a
M0923_1.02
Mus musculus
NNHAAYNN

NNRTTDNN
PBM
Berger et al.(2008)
Phox2a_3947
0.702
PHOX2B
M5715_1.02
Homo sapiens
TAAYBYAATTA

TAATTRVRTTA
SELEX
Jolma et al.(2013)
PHOX2B_1
0.702
PRRX2
M3796_1.02
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRRX2_05
0.702
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M0900_1.02 Homeodomain 1 57

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000335505 Homeodomain 118 174
ENSP00000370987 Homeodomain 118 174
ENSP00000370990 Homeodomain 118 174

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

0 Related TFs

">No related TF found