ZFX (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000005889 T094775_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZFX
M08850_2.00		 Homo sapiens
YBVGGCCTVS
SBAGGCCBVR		 Misc
Kulakovskiy et al.(2013)
ZFX_HUMAN.H11MO.0.A		 (Direct) (Direct)
ZFX
M10098_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZFX_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zfx
M08100_2.00 		Mus musculus
BBVRSCBVGGCCTV
BAGGCCBVGSYBVV		 ChIP-seq
Mathelier et al.(2014)
MA0146.2 		0.822 0.993
Zfx
M09017_2.00 		Mus musculus
VVSVSBNBBAGGCCBVGSH
DSCBVGGCCTVVNVSBSBB		 Misc
Kulakovskiy et al.(2013)
ZFX_MOUSE.H11MO.0.B 		0.822 0.993
Zfx
M09517_2.00 		Mus musculus
BNAGGCCT
AGGCCTNV		 Misc
Heinz et al.(2010)
mES-Zfx_GSE11431 		0.822 0.993
Zfx
M00788_2.00 		Mus musculus
NRGGCCNNN
NNNGGCCYN		 PBM
Weirauch et al.(2013)
pTH2933 		0.821 0.990
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000304985 C2H2 ZF 425 447
ENSP00000304985 C2H2 ZF 456 478
ENSP00000304985 C2H2 ZF 488 510
ENSP00000304985 C2H2 ZF 519 542
ENSP00000304985 C2H2 ZF 548 570
ENSP00000304985 C2H2 ZF 576 599
ENSP00000304985 C2H2 ZF 605 627
ENSP00000304985 C2H2 ZF 633 656
ENSP00000304985 C2H2 ZF 662 684
ENSP00000304985 C2H2 ZF 690 713
ENSP00000304985 C2H2 ZF 719 741
ENSP00000304985 C2H2 ZF 747 770
ENSP00000304985 C2H2 ZF 776 799
ENSP00000343384 C2H2 ZF 375 397
ENSP00000343384 C2H2 ZF 406 428
ENSP00000343384 C2H2 ZF 438 460
ENSP00000343384 C2H2 ZF 469 492
ENSP00000343384 C2H2 ZF 498 520
ENSP00000343384 C2H2 ZF 526 549
ENSP00000343384 C2H2 ZF 555 577
ENSP00000343384 C2H2 ZF 583 606
ENSP00000343384 C2H2 ZF 612 634
ENSP00000343384 C2H2 ZF 640 663
ENSP00000343384 C2H2 ZF 669 691
ENSP00000343384 C2H2 ZF 697 720
ENSP00000343384 C2H2 ZF 726 749
ENSP00000368475 C2H2 ZF 425 447
ENSP00000368475 C2H2 ZF 456 478
ENSP00000368475 C2H2 ZF 488 510
ENSP00000368475 C2H2 ZF 519 542
ENSP00000368475 C2H2 ZF 548 570
ENSP00000368475 C2H2 ZF 576 599
ENSP00000368475 C2H2 ZF 605 627
ENSP00000368475 C2H2 ZF 633 656
ENSP00000368475 C2H2 ZF 662 684
ENSP00000368475 C2H2 ZF 690 713
ENSP00000368475 C2H2 ZF 719 741
ENSP00000368475 C2H2 ZF 747 770
ENSP00000368475 C2H2 ZF 776 799
ENSP00000368486 C2H2 ZF 464 486
ENSP00000368486 C2H2 ZF 495 517
ENSP00000368486 C2H2 ZF 527 549
ENSP00000368486 C2H2 ZF 558 581
ENSP00000368486 C2H2 ZF 587 609
ENSP00000368486 C2H2 ZF 615 638
ENSP00000368486 C2H2 ZF 644 666
ENSP00000368486 C2H2 ZF 672 695
ENSP00000368486 C2H2 ZF 701 723
ENSP00000368486 C2H2 ZF 729 752
ENSP00000368486 C2H2 ZF 758 780
ENSP00000368486 C2H2 ZF 786 809
ENSP00000368486 C2H2 ZF 815 838
ENSP00000438233 C2H2 ZF 196 218
ENSP00000438233 C2H2 ZF 227 249
ENSP00000438233 C2H2 ZF 259 281
ENSP00000438233 C2H2 ZF 290 313
ENSP00000438233 C2H2 ZF 319 341
ENSP00000438233 C2H2 ZF 347 370
ENSP00000438233 C2H2 ZF 376 398
ENSP00000438233 C2H2 ZF 404 427
ENSP00000438233 C2H2 ZF 433 455
ENSP00000438233 C2H2 ZF 461 484
ENSP00000438233 C2H2 ZF 490 512
ENSP00000438233 C2H2 ZF 518 541
ENSP00000438233 C2H2 ZF 547 570

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ZFX Pan troglodytes ENSPTRG00000021747 I 0.827
ZFX Gorilla gorilla ENSGGOG00000004053 I 0.827
ENSPPYG00000020195 Pongo abelii ENSPPYG00000020195 I 0.827
Zfx Rattus norvegicus ENSRNOG00000005624 I 0.823
Zfx Mus musculus ENSMUSG00000079509 D 0.822
Myotis_brandtii_ZFX_10010226 Myotis brandtii Myotis_brandtii_ZFX_10010226 I 0.809
ENSPANG00000000982 Papio anubis ENSPANG00000000982 I 0.809
ENSOARG00000017137 Ovis aries ENSOARG00000017137 I 0.809
ENSP00000304985 Macaca fascicularis ENSP00000304985 I 0.809
ZFX Oryctolagus cuniculus ENSOCUG00000003815 I 0.809
ENSBTAP00000010165-D1 Bos grunniens ENSBTAP00000010165-D1 I 0.809
ENSSHAG00000004983 Sarcophilus harrisii ENSSHAG00000004983 I 0.809
ENSSSCG00000021322 Sus scrofa ENSSSCG00000021322 I 0.809
ENSMPUG00000000105 Mustela putorius furo ENSMPUG00000000105 I 0.809
ZFX Pteropus vampyrus ENSPVAG00000002534 I 0.809
ZFX Tursiops truncatus ENSTTRG00000012488 I 0.809
ENSSTOG00000007158 Ictidomys tridecemlineatus ENSSTOG00000007158 I 0.809
ENSNLEG00000010044 Nomascus leucogenys ENSNLEG00000010044 I 0.809
ENSCPOG00000011739 Cavia porcellus ENSCPOG00000011739 I 0.809
ZFX Monodelphis domestica ENSMODG00000007512 I 0.809
ZFX Equus caballus ENSECAG00000025018 I 0.809
ZFX Callithrix jacchus ENSCJAG00000004841 I 0.809
ZFX Canis familiaris ENSCAFG00000013408 I 0.809
ENSAMEG00000012681 Ailuropoda melanoleuca ENSAMEG00000012681 I 0.809
ZFY Bos taurus ENSBTAG00000007730 I 0.809
ZFX Felis catus ENSFCAG00000010544 I 0.809
ZFX Dasypus novemcinctus ENSDNOG00000034569 I 0.809
ZFX Macaca mulatta ENSMMUG00000009801 I 0.809
ZFY Myotis lucifugus ENSMLUG00000003962 I 0.809
ZFX Microcebus murinus ENSMICG00000009517 I 0.809
ENSSSCG00000012179 Sus scrofa ENSSSCG00000012179 I 0.808
ENSCSAG00000018321 Chlorocebus sabaeus ENSCSAG00000018321 I 0.806
ZFX Loxodonta africana ENSLAFG00000006691 I 0.803
ZFY Pan troglodytes ENSPTRG00000022471 I 0.802
ZFY Homo sapiens ENSG00000067646 I 0.799
Pvit_09540 Pogona vitticeps Pvit_09540 I 0.787
Ogr18022 Ophisaurus gracilis Ogr18022 I 0.785
ENSACAG00000007227 Anolis carolinensis ENSACAG00000007227 I 0.785
ZFX Ornithorhynchus anatinus ENSOANG00000011502 I 0.771
ENSTSYG00000005088 Tarsius syrichta ENSTSYG00000005088 I 0.770
Myotis_brandtii_ZFX_10001428 Myotis brandtii Myotis_brandtii_ZFX_10001428 I 0.759