SNAI2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000019549 T094783_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SNAI2
M00220_2.00
Homo sapiens
NHACCTGY

RCAGGTDN
PBM
Barrera et al.(2016)
SNAI2_D119E
(Direct) (Direct)
SNAI2
M00221_2.00
Homo sapiens
HACYTGH

DCARGTD
PBM
Barrera et al.(2016)
SNAI2_REF
(Direct) (Direct)
SNAI2
M00222_2.00
Homo sapiens
HACYTGHNNN

NNNDCARGTD
PBM
Barrera et al.(2016)
SNAI2_T234I
(Direct) (Direct)
SNAI2
M02873_2.00
Homo sapiens
VCACCTGYN

NRCAGGTGB
SELEX
Jolma et al.(2013)
SNAI2_1
(Direct) (Direct)
SNAI2
M04392_2.00
Homo sapiens
YGCACCTGYY

RRCAGGTGCR
SELEX
Yin et al.(2017)
SNAI2_eDBD_HT-SELEX
(Direct) (Direct)
SNAI2
M04393_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M04394_2.00
Homo sapiens
YRCACCTGYY

RRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_HT-SELEX
(Direct) (Direct)
SNAI2
M04395_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M08853_2.00
Homo sapiens
NVCACCTGYY

RRCAGGTGBN
Misc
Kulakovskiy et al.(2013)
SNAI2_HUMAN.H11MO.0.A
(Direct) (Direct)
SNAI2
M10102_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_01
(Direct) (Direct)
SNAI2
M10103_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_02
(Direct) (Direct)
SNAI2
M10104_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Snai2
M08973_2.00
Mus musculus
VNRCACCTGYY

RRCAGGTGYNB
Misc
Kulakovskiy et al.(2013)
SNAI2_MOUSE.H11MO.0.A
0.827 1.000
esg
M06050_2.00
Drosophila melanogaster
CACCTGH

DCAGGTG
B1H
Zhu et al.(2011)
esg_SANGER_2.5_FBgn0001981
0.767 0.816
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00220_2.00 C2H2 ZF 15 37
M00220_2.00 C2H2 ZF 46 68
M00220_2.00 C2H2 ZF 72 94
M00220_2.00 C2H2 ZF 100 122
M00220_2.00 C2H2 ZF 128 149
M00221_2.00 C2H2 ZF 15 37
M00221_2.00 C2H2 ZF 46 68
M00221_2.00 C2H2 ZF 72 94
M00221_2.00 C2H2 ZF 100 122
M00221_2.00 C2H2 ZF 128 149
M00222_2.00 C2H2 ZF 15 37
M00222_2.00 C2H2 ZF 46 68
M00222_2.00 C2H2 ZF 72 94
M00222_2.00 C2H2 ZF 100 122
M00222_2.00 C2H2 ZF 128 149

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000020945 C2H2 ZF 128 150
ENSP00000020945 C2H2 ZF 159 181
ENSP00000020945 C2H2 ZF 185 207
ENSP00000020945 C2H2 ZF 213 235
ENSP00000020945 C2H2 ZF 241 262
ENSP00000380034 C2H2 ZF 128 150
ENSP00000380034 C2H2 ZF 159 181
ENSP00000380034 C2H2 ZF 185 207
ENSP00000380034 C2H2 ZF 213 235
ENSP00000380034 C2H2 ZF 241 262

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

103 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
TCM_019507 Theobroma cacao TCM_019507 N 0.000
30167.m000852 Ricinus communis 30167.m000852 N 0.000
cassava35798.valid.m1 Manihot esculenta cassava35798.valid.m1 N 0.000
Cucsa.031620 Cucumis sativus Cucsa.031620 N 0.000
mgf026281m Mimulus guttatus mgf026281m N 0.000
mgf026496m Mimulus guttatus mgf026496m N 0.000
Aquca_027_00369 Aquilegia coerulea Aquca_027_00369 N 0.000
Bostr.23794s0314 Boechera stricta Bostr.23794s0314 N 0.000
Cagra.18121s0004 Capsella grandiflora Cagra.18121s0004 N 0.000
29767.m000199 Ricinus communis 29767.m000199 N 0.000
28603.m000172 Ricinus communis 28603.m000172 N 0.000
TCM_021932 Theobroma cacao TCM_021932 N 0.000
Traes_5DS_8F3BD4450 Triticum aestivum Traes_5DS_8F3BD4450 N 0.000
TRIUR3_13997 Triticum urartu TRIUR3_13997 N 0.000
VIT_08s0007g00410 Vitis vinifera VIT_08s0007g00410 N 0.000
VIT_14s0083g00120 Vitis vinifera VIT_14s0083g00120 N 0.000
Ca_21130 Cicer arietinum Ca_21130 N 0.000
Cla007228 Citrullus lanatus Cla007228 N 0.000
Pm002699 Prunus mume Pm002699 N 0.000
Carubv10023471m.g Capsella rubella Carubv10023471m.g N 0.000
Ciclev10011915m.g Citrus clementina Ciclev10011915m.g N 0.000
Ciclev10012089m.g Citrus clementina Ciclev10012089m.g N 0.000
MDP0000708334 Malus domestica MDP0000708334 N 0.000
orange1.1g018768m.g Citrus sinensis orange1.1g018768m.g N 0.000
Pavir.Cb00486 Panicum virgatum Pavir.Cb00486 N 0.000
SapurV1A.0001s1780 Salix purpurea SapurV1A.0001s1780 N 0.000
SapurV1A.0101s0440 Salix purpurea SapurV1A.0101s0440 N 0.000
Thhalv10016830m.g Eutrema salsugineum Thhalv10016830m.g N 0.000
PK14097.1 Cannabis sativa PK14097.1 N 0.000
chr3.LjT11G09.150.nc Lotus japonicus chr3.LjT11G09.150.nc N 0.000
MDP0000282792 Malus domestica MDP0000282792 N 0.000
MDP0000252887 Malus domestica MDP0000252887 N 0.000
Eucgr.K03130 Eucalyptus grandis Eucgr.K03130 N 0.000
evm.TU.supercontig_333.1 Carica papaya evm.TU.supercontig_333.1 N 0.000
gene08535-v1.0-hybrid Fragaria vesca gene08535-v1.0-hybrid N 0.000
gene10329-v1.0-hybrid Fragaria vesca gene10329-v1.0-hybrid N 0.000
gene18421-v1.0-hybrid Fragaria vesca gene18421-v1.0-hybrid N 0.000
Gorai.012G104100 Gossypium raimondii Gorai.012G104100 N 0.000
Lus10024392.g Linum usitatissimum Lus10024392.g N 0.000
Lus10025355.g Linum usitatissimum Lus10025355.g N 0.000
chr3.LjT11G09.160.nc Lotus japonicus chr3.LjT11G09.160.nc N 0.000
AMTR_s00044p00233260 Amborella trichopoda AMTR_s00044p00233260 N 0.000
GLYMA07G15850 Glycine max GLYMA07G15850 N 0.000
GLYMA18G26600 Glycine max GLYMA18G26600 N 0.000
GLYMA18G39771 Glycine max GLYMA18G39771 N 0.000
GRMZM2G403620 Zea mays GRMZM2G403620 N 0.000
GSMUA_Achr5G29070_001 Musa acuminata GSMUA_Achr5G29070_001 N 0.000
GSMUA_Achr7G10550_001 Musa acuminata GSMUA_Achr7G10550_001 N 0.000
GSMUA_Achr9G03320_001 Musa acuminata GSMUA_Achr9G03320_001 N 0.000
GSMUA_Achr9G19380_001 Musa acuminata GSMUA_Achr9G19380_001 N 0.000
GLYMA03G19030 Glycine max GLYMA03G19030 N 0.000
fgenesh1_pm.C_scaffold_4001520 Arabidopsis lyrata fgenesh1_pm.C_scaffold_4001520 N 0.000
AS1 Arabidopsis thaliana AT2G37630 N 0.000
BGIOSGA035973 Oryza indica BGIOSGA035973 N 0.000
BGIOSGA037216 Oryza indica BGIOSGA037216 N 0.000
Bo3g031880 Brassica oleracea Bo3g031880 N 0.000
Bo4g030340 Brassica oleracea Bo4g030340 N 0.000
Bra000011 Brassica rapa Bra000011 N 0.000
Bra005177 Brassica rapa Bra005177 N 0.000
BRADI4G03970 Brachypodium distachyon BRADI4G03970 N 0.000
GSMUA_Achr9G28330_001 Musa acuminata GSMUA_Achr9G28330_001 N 0.000
LPERR12G13690 Leersia perrieri LPERR12G13690 N 0.000
MTR_7g061550 Medicago truncatula MTR_7g061550 N 0.000
POPTR_0004s10250 Populus trichocarpa POPTR_0004s10250 N 0.000
POPTR_0006s08610 Populus trichocarpa POPTR_0006s08610 N 0.000
POPTR_0017s13950 Populus trichocarpa POPTR_0017s13950 N 0.000
PRUPE_ppa007753mg Prunus persica PRUPE_ppa007753mg N 0.000
Sb08g018840 Sorghum bicolor Sb08g018840 N 0.000
scaffold_402408.1 Arabidopsis lyrata scaffold_402408.1 N 0.000
SELMODRAFT_140962 Selaginella moellendorffii SELMODRAFT_140962 N 0.000
SELMODRAFT_270481 Selaginella moellendorffii SELMODRAFT_270481 N 0.000
PGSC0003DMG400008834 Solanum tuberosum PGSC0003DMG400008834 N 0.000
OS12G0572000 Oryza sativa OS12G0572000 N 0.000
OB12G23330 Oryza brachyantha OB12G23330 N 0.000
OBART12G16450 Oryza barthii OBART12G16450 N 0.000
OGLUM12G18010 Oryza glumaepatula OGLUM12G18010 N 0.000
OMERI08G15890 Oryza meridionalis OMERI08G15890 N 0.000
ONIVA02G22170 Oryza nivara ONIVA02G22170 N 0.000
OPUNC12G14950 Oryza punctata OPUNC12G14950 N 0.000
ORGLA12G0144700 Oryza glaberrima ORGLA12G0144700 N 0.000
ORUFI12G18280 Oryza rufipogon ORUFI12G18280 N 0.000
Solyc09g010840.1 Solanum lycopersicum Solyc09g010840.1 N 0.000