SNAI2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000019549 T094783_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SNAI2
M00220_2.00
Homo sapiens
NHACCTGY

RCAGGTDN
PBM
Barrera et al.(2016)
SNAI2_D119E
(Direct) (Direct)
SNAI2
M00221_2.00
Homo sapiens
HACYTGH

DCARGTD
PBM
Barrera et al.(2016)
SNAI2_REF
(Direct) (Direct)
SNAI2
M00222_2.00
Homo sapiens
HACYTGHNNN

NNNDCARGTD
PBM
Barrera et al.(2016)
SNAI2_T234I
(Direct) (Direct)
SNAI2
M02873_2.00
Homo sapiens
VCACCTGYN

NRCAGGTGB
SELEX
Jolma et al.(2013)
SNAI2_1
(Direct) (Direct)
SNAI2
M04392_2.00
Homo sapiens
YGCACCTGYY

RRCAGGTGCR
SELEX
Yin et al.(2017)
SNAI2_eDBD_HT-SELEX
(Direct) (Direct)
SNAI2
M04393_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M04394_2.00
Homo sapiens
YRCACCTGYY

RRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_HT-SELEX
(Direct) (Direct)
SNAI2
M04395_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M08853_2.00
Homo sapiens
NVCACCTGYY

RRCAGGTGBN
Misc
Kulakovskiy et al.(2013)
SNAI2_HUMAN.H11MO.0.A
(Direct) (Direct)
SNAI2
M10102_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_01
(Direct) (Direct)
SNAI2
M10103_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_02
(Direct) (Direct)
SNAI2
M10104_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Snai2
M08973_2.00
Mus musculus
VNRCACCTGYY

RRCAGGTGYNB
Misc
Kulakovskiy et al.(2013)
SNAI2_MOUSE.H11MO.0.A
0.827 1.000
esg
M06050_2.00
Drosophila melanogaster
CACCTGH

DCAGGTG
B1H
Zhu et al.(2011)
esg_SANGER_2.5_FBgn0001981
0.767 0.816
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00220_2.00 C2H2 ZF 15 37
M00220_2.00 C2H2 ZF 46 68
M00220_2.00 C2H2 ZF 72 94
M00220_2.00 C2H2 ZF 100 122
M00220_2.00 C2H2 ZF 128 149
M00221_2.00 C2H2 ZF 15 37
M00221_2.00 C2H2 ZF 46 68
M00221_2.00 C2H2 ZF 72 94
M00221_2.00 C2H2 ZF 100 122
M00221_2.00 C2H2 ZF 128 149
M00222_2.00 C2H2 ZF 15 37
M00222_2.00 C2H2 ZF 46 68
M00222_2.00 C2H2 ZF 72 94
M00222_2.00 C2H2 ZF 100 122
M00222_2.00 C2H2 ZF 128 149

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000020945 C2H2 ZF 128 150
ENSP00000020945 C2H2 ZF 159 181
ENSP00000020945 C2H2 ZF 185 207
ENSP00000020945 C2H2 ZF 213 235
ENSP00000020945 C2H2 ZF 241 262
ENSP00000380034 C2H2 ZF 128 150
ENSP00000380034 C2H2 ZF 159 181
ENSP00000380034 C2H2 ZF 185 207
ENSP00000380034 C2H2 ZF 213 235
ENSP00000380034 C2H2 ZF 241 262

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

103 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
NCU01243 Neurospora crassa NCU01243 D 0.000
MCYG_03841 Arthroderma otae MCYG_03841 I 0.000
PODANS_2_3270 Podospora anserina PODANS_2_3270 I 0.000
PTRG_09915 Pyrenophora triticirepentis PTRG_09915 I 0.000
PTT_08856 Pyrenophora teres PTT_08856 I 0.000
PV04_09113 Capronia semiimmersa PV04_09113 I 0.000
PV05_00645 Exophiala xenobiotica PV05_00645 I 0.000
PV06_07336 Exophiala oligosperma PV06_07336 I 0.000
PV07_00703 Cladophialophora immunda PV07_00703 I 0.000
PV08_01635 Exophiala spinifera PV08_01635 I 0.000
PV09_05237 Verruconis gallopava PV09_05237 I 0.000
PV10_04586 Exophiala mesophila PV10_04586 I 0.000
PV11_02999 Exophiala sideris PV11_02999 I 0.000
S40285_04268 Stachybotrys chlorohalonata S40285_04268 I 0.000
S40288_01230 Stachybotrys chartarum S40288_01230 I 0.000
SAPIO_CDS10407 Scedosporium apiospermum SAPIO_CDS10407 I 0.000
PMAA_038040 Talaromyces marneffei PMAA_038040 I 0.000
PITC_083010 Penicillium italicum PITC_083010 I 0.000
PFICI_07655 Pestalotiopsis fici PFICI_07655 I 0.000
MGG_07063 Magnaporthe oryzae MGG_07063 I 0.000
MGU_05868 Metarhizium guizhouense MGU_05868 I 0.000
MGYG_07809 Microsporum gypseum MGYG_07809 I 0.000
MPH_02318 Macrophomina phaseolina MPH_02318 I 0.000
MYCFIDRAFT_131841 Pseudocercospora fijiensis MYCFIDRAFT_131841 I 0.000
Mycgr3G79543 Zymoseptoria tritici Mycgr3G79543 I 0.000
MYCTH_2300589 Myceliophthora thermophila MYCTH_2300589 I 0.000
NechaG105273 Fusarium solani NechaG105273 I 0.000
NEUTE1DRAFT_57664 Neurospora tetrasperma NEUTE1DRAFT_57664 I 0.000
OIDMADRAFT_115449 Oidiodendron maius OIDMADRAFT_115449 I 0.000
PCH_Pc21g01880 Penicillium rubens PCH_Pc21g01880 I 0.000
PDE_07750 Penicillium oxalicum PDE_07750 I 0.000
PDIP_80460 Penicillium digitatum PDIP_80460 I 0.000
PEX1_034880 Penicillium expansum PEX1_034880 I 0.000
SBOR_5353 Sclerotinia borealis SBOR_5353 I 0.000
SEPMUDRAFT_60609 Sphaerulina musiva SEPMUDRAFT_60609 I 0.000
UV8b_2437 Ustilaginoidea virens UV8b_2437 I 0.000
V499_03435 Pseudogymnoascus pannorum V499_03435 I 0.000
VDAG_08332 Verticillium dahliae VDAG_08332 I 0.000
VDBG_00044 Verticillium alfalfae VDBG_00044 I 0.000
VHEMI01335 Torrubiella hemipterigena VHEMI01335 I 0.000
Z517_05341 Fonsecaea pedrosoi Z517_05341 I 0.000
Z519_01699 Cladophialophora bantiana Z519_01699 I 0.000
estExt_fgenesh1_pg.C_10631 Cochliobolus heterostrophus C5 estExt_fgenesh1_pg.C_10631 I 0.000
estExt_fgenesh1_pm.C_sca_6_chr9_2_00089 Nectria haematococca estExt_fgenesh1_pm.C_sca_6_chr9_2_00089 I 0.000
estExt_Genewise1Plus.C_11214 Neurospora discreta estExt_Genewise1Plus.C_11214 I 0.000
fgenesh1_kg.C_chr_2000382 Mycosphaerella graminicola fgenesh1_kg.C_chr_2000382 I 0.000
AB00299.1 Alternaria brassicicola AB00299.1 I 0.000
estExt_fgenesh1_pg.C_11203 Cryphonectria parasitica estExt_fgenesh1_pg.C_11203 I 0.000
fgenesh1_pm.00815_#_36 Aspergillus carbonarius fgenesh1_pm.00815_#_36 I 0.000
PMAA_038040 Penicillium marneffei PMAA_038040 I 0.000
UCRPA7_1548 Togninia minima UCRPA7_1548 I 0.000
UCRNP2_4556 Neofusicoccum parvum UCRNP2_4556 I 0.000
SETTUDRAFT_102674 Setosphaeria turcica SETTUDRAFT_102674 I 0.000
SMAC_03943 Sordaria macrospora SMAC_03943 I 0.000
SNOG_10444 Phaeosphaeria nodorum SNOG_10444 I 0.000
SPBR_08176 Sporothrix brasiliensis SPBR_08176 I 0.000
TEQG_03253 Trichophyton equinum TEQG_03253 I 0.000
TESG_04315 Trichophyton tonsurans TESG_04315 I 0.000
THITE_2106716 Thielavia terrestris THITE_2106716 I 0.000
TRIATDRAFT_233014 Trichoderma atroviride TRIATDRAFT_233014 I 0.000
TRIREDRAFT_23294 Trichoderma reesei TRIREDRAFT_23294 I 0.000
TRIVIDRAFT_63141 Trichoderma virens TRIVIDRAFT_63141 I 0.000
TRV_02459 Trichophyton verrucosum TRV_02459 I 0.000
TSTA_053980 Talaromyces stipitatus TSTA_053980 I 0.000
U727_00430142291 Penicillium solitum U727_00430142291 I 0.000
UCREL1_4926 Eutypa lata UCREL1_4926 I 0.000
Pc21g01880 Penicillium chrysogenum Pc21g01880 I 0.000
MBR_03811 Metarhizium brunneum MBR_03811 I 0.000
COCSADRAFT_174784 Bipolaris sorokiniana COCSADRAFT_174784 I 0.000
AFUA_2G16160 Aspergillus fumigatus CADAFUAG00004679 I 0.000
CADANGAG00012333 Aspergillus niger CADANGAG00012333 I 0.000
ANIA_02136 Aspergillus nidulans CADANIAG00008814 I 0.000
CADAORAG00005796 Aspergillus oryzae CADAORAG00005796 I 0.000
ATEG_02328 Aspergillus terreus CADATEAG00000227 I 0.000
NFIA_091420 Neosartorya fischeri CADNFIAG00007675 I 0.000
CCM_05608 Cordyceps militaris CCM_05608 I 0.000
CFIO01_07548 Colletotrichum fioriniae CFIO01_07548 I 0.000
CGGC5_11552 Colletotrichum gloeosporioides CGGC5_11552 I 0.000
CH063_02161 Colletotrichum higginsianum CH063_02161 I 0.000
CHGG_02677 Chaetomium globosum CHGG_02677 I 0.000
CMQ_6311 Grosmannia clavigera CMQ_6311 I 0.000
Cob_12019 Colletotrichum orbiculare Cob_12019 I 0.000
COCC4DRAFT_56976 Bipolaris maydis COCC4DRAFT_56976 I 0.000
CADAFLAG00003349 Aspergillus flavus CADAFLAG00003349 I 0.000
ACLA_075120 Aspergillus clavatus CADACLAG00006456 I 0.000
BGHDH14_bgh04283 Blumeria graminis BGHDH14_bgh04283 I 0.000
MCYG_03841 Microsporum canis MCYG_03841 I 0.000
SNOG_10444 Stagonospora nodorum SNOG_10444 I 0.000
VDBG_00044 Verticillium albo atrum VDBG_00044 I 0.000
A1O1_02644 Capronia coronata A1O1_02644 I 0.000
A1O3_05207 Capronia epimyces A1O3_05207 I 0.000
A1O5_01739 Cladophialophora psammophila A1O5_01739 I 0.000
A1O7_08560 Cladophialophora yegresii A1O7_08560 I 0.000
ACRE_049560 Acremonium chrysogenum ACRE_049560 I 0.000
AOL_s00083g408 Arthrobotrys oligospora AOL_s00083g408 I 0.000
ARB_03230 Arthroderma benhamiae ARB_03230 I 0.000
AUEXF2481DRAFT_29116 Aureobasidium subglaciale AUEXF2481DRAFT_29116 I 0.000
BAUCODRAFT_66299 Baudoinia compniacensis BAUCODRAFT_66299 I 0.000
BBA_00830 Beauveria bassiana BBA_00830 I 0.000
Bcin08g06020 Botrytis cinerea Bcin08g06020 I 0.000
COCCADRAFT_27331 Bipolaris zeicola COCCADRAFT_27331 I 0.000
COCMIDRAFT_2306 Bipolaris oryzae COCMIDRAFT_2306 I 0.000
GMDG_05406 Pseudogymnoascus destructans GMDG_05406 I 0.000
MAPG_11053 Magnaporthe poae MAPG_11053 I 0.000
GSTUM_00005719001 Tuber melanosporum GSTUM_00005719001 I 0.000
H072_1268 Dactylellina haptotyla H072_1268 I 0.000
H101_06083 Trichophyton interdigitale H101_06083 I 0.000
H102_03959 Trichophyton rubrum H102_03959 I 0.000
H105_03987 Trichophyton soudanense H105_03987 I 0.000
HMPREF1120_00798 Exophiala dermatitidis HMPREF1120_00798 I 0.000
HMPREF1624_01153 Sporothrix schenckii HMPREF1624_01153 I 0.000
M437DRAFT_36734 Aureobasidium melanogenum M437DRAFT_36734 I 0.000
M438DRAFT_279552 Aureobasidium pullulans M438DRAFT_279552 I 0.000
MAC_00493 Metarhizium acridum MAC_00493 I 0.000
MAJ_02006 Metarhizium majus MAJ_02006 I 0.000
MAM_07504 Metarhizium album MAM_07504 I 0.000
GLRG_03269 Colletotrichum graminicola GLRG_03269 I 0.000
GGTG_00248 Gaeumannomyces graminis GGTG_00248 I 0.000
G647_07533 Cladophialophora carrionii G647_07533 I 0.000
COCVIDRAFT_17513 Bipolaris victoriae COCVIDRAFT_17513 I 0.000
MBM_03820 Marssonina brunnea MBM_03820 I 0.000
CPUR_06724 Claviceps purpurea CPUR_06724 I 0.000
CSUB01_02966 Colletotrichum sublineola CSUB01_02966 I 0.000
CTHT_0052970 Chaetomium thermophilum CTHT_0052970 I 0.000
DOTSEDRAFT_122593 Dothistroma septosporum DOTSEDRAFT_122593 I 0.000
EURHEDRAFT_376515 Aspergillus ruber EURHEDRAFT_376515 I 0.000
EV44_g5594 Erysiphe necator EV44_g5594 I 0.000
F503_00618 Ophiostoma piceae uamh F503_00618 I 0.000
FFUJ_02710 Fusarium fujikuroi FFUJ_02710 I 0.000
FGRRES_07133 Fusarium graminearum FGRRES_07133 I 0.000
FPSE_04097 Fusarium pseudograminearum FPSE_04097 I 0.000
FVEG_08032 Fusarium verticillioides FVEG_08032 I 0.000
MANI_005306 Metarhizium anisopliae MANI_005306 I 0.000
CIMG_09527 Coccidioides immitis CIMG_09527 N 0.000
CPC735_018780 Coccidioides posadasii CPC735_018780 N 0.000
UREG_04794 Uncinocarpus reesii UREG_04794 N 0.000