CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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SNAI2
(
Homo sapiens
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSG00000019549
T094783_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SNAI2
M00220_2.00
Homo sapiens
NHACCTGY
RCAGGTDN
PBM
Barrera et al.(2016)
SNAI2_D119E
(Direct)
(Direct)
SNAI2
M00221_2.00
Homo sapiens
HACYTGH
DCARGTD
PBM
Barrera et al.(2016)
SNAI2_REF
(Direct)
(Direct)
SNAI2
M00222_2.00
Homo sapiens
HACYTGHNNN
NNNDCARGTD
PBM
Barrera et al.(2016)
SNAI2_T234I
(Direct)
(Direct)
SNAI2
M02873_2.00
Homo sapiens
VCACCTGYN
NRCAGGTGB
SELEX
Jolma et al.(2013)
SNAI2_1
(Direct)
(Direct)
SNAI2
M04392_2.00
Homo sapiens
YGCACCTGYY
RRCAGGTGCR
SELEX
Yin et al.(2017)
SNAI2_eDBD_HT-SELEX
(Direct)
(Direct)
SNAI2
M04393_2.00
Homo sapiens
YRCACCTGYN
NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
SNAI2
M04394_2.00
Homo sapiens
YRCACCTGYY
RRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_HT-SELEX
(Direct)
(Direct)
SNAI2
M04395_2.00
Homo sapiens
YRCACCTGYN
NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_Methyl-HT-SELEX
(Direct)
(Direct)
SNAI2
M08853_2.00
Homo sapiens
NVCACCTGYY
RRCAGGTGBN
Misc
Kulakovskiy et al.(2013)
SNAI2_HUMAN.H11MO.0.A
(Direct)
(Direct)
SNAI2
M10102_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_01
(Direct)
(Direct)
SNAI2
M10103_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_02
(Direct)
(Direct)
SNAI2
M10104_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Snai2
M08973_2.00
Mus musculus
VNRCACCTGYY
RRCAGGTGYNB
Misc
Kulakovskiy et al.(2013)
SNAI2_MOUSE.H11MO.0.A
0.827
1.000
esg
M06050_2.00
Drosophila melanogaster
CACCTGH
DCAGGTG
B1H
Zhu et al.(2011)
esg_SANGER_2.5_FBgn0001981
0.767
0.816
For this family, TFs with SR scores >
0.755
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00220_2.00
C2H2 ZF
15
37
FQCNLCNKTYSTFSGLAKHKQLH
M00220_2.00
C2H2 ZF
46
68
FSCKYCDKEYVSLGALKMHIRTH
M00220_2.00
C2H2 ZF
72
94
CVCKICGKAFSRPWLLQGHIRTH
M00220_2.00
C2H2 ZF
100
122
FSCPHCNRAFADRSNLRAHLQTH
M00220_2.00
C2H2 ZF
128
149
YQCKNCSKTFSRMSLLHKHEES
M00221_2.00
C2H2 ZF
15
37
FQCNLCNKTYSTFSGLAKHKQLH
M00221_2.00
C2H2 ZF
46
68
FSCKYCDKEYVSLGALKMHIRTH
M00221_2.00
C2H2 ZF
72
94
CVCKICGKAFSRPWLLQGHIRTH
M00221_2.00
C2H2 ZF
100
122
FSCPHCNRAFADRSNLRAHLQTH
M00221_2.00
C2H2 ZF
128
149
YQCKNCSKTFSRMSLLHKHEES
M00222_2.00
C2H2 ZF
15
37
FQCNLCNKTYSTFSGLAKHKQLH
M00222_2.00
C2H2 ZF
46
68
FSCKYCDKEYVSLGALKMHIRTH
M00222_2.00
C2H2 ZF
72
94
CVCKICGKAFSRPWLLQGHIRTH
M00222_2.00
C2H2 ZF
100
122
FSCPHCNRAFADRSNLRAHLQIH
M00222_2.00
C2H2 ZF
128
149
YQCKNCSKTFSRMSLLHKHEES
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000020945
C2H2 ZF
128
150
FQCNLCNKTYSTFSGLAKHKQLH
ENSP00000020945
C2H2 ZF
159
181
FSCKYCDKEYVSLGALKMHIRTH
ENSP00000020945
C2H2 ZF
185
207
CVCKICGKAFSRPWLLQGHIRTH
ENSP00000020945
C2H2 ZF
213
235
FSCPHCNRAFADRSNLRAHLQTH
ENSP00000020945
C2H2 ZF
241
262
YQCKNCSKTFSRMSLLHKHEES
ENSP00000380034
C2H2 ZF
128
150
FQCNLCNKTYSTFSGLAKHKQLH
ENSP00000380034
C2H2 ZF
159
181
FSCKYCDKEYVSLGALKMHIRTH
ENSP00000380034
C2H2 ZF
185
207
CVCKICGKAFSRPWLLQGHIRTH
ENSP00000380034
C2H2 ZF
213
235
FSCPHCNRAFADRSNLRAHLQTH
ENSP00000380034
C2H2 ZF
241
262
YQCKNCSKTFSRMSLLHKHEES
Links
Other
C2H2 ZF
family TFs
Other
Homo sapiens
TFs
103 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy