SNAI2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000019549 T094783_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SNAI2
M00220_2.00
Homo sapiens
NHACCTGY

RCAGGTDN
PBM
Barrera et al.(2016)
SNAI2_D119E
(Direct) (Direct)
SNAI2
M00221_2.00
Homo sapiens
HACYTGH

DCARGTD
PBM
Barrera et al.(2016)
SNAI2_REF
(Direct) (Direct)
SNAI2
M00222_2.00
Homo sapiens
HACYTGHNNN

NNNDCARGTD
PBM
Barrera et al.(2016)
SNAI2_T234I
(Direct) (Direct)
SNAI2
M02873_2.00
Homo sapiens
VCACCTGYN

NRCAGGTGB
SELEX
Jolma et al.(2013)
SNAI2_1
(Direct) (Direct)
SNAI2
M04392_2.00
Homo sapiens
YGCACCTGYY

RRCAGGTGCR
SELEX
Yin et al.(2017)
SNAI2_eDBD_HT-SELEX
(Direct) (Direct)
SNAI2
M04393_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M04394_2.00
Homo sapiens
YRCACCTGYY

RRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_HT-SELEX
(Direct) (Direct)
SNAI2
M04395_2.00
Homo sapiens
YRCACCTGYN

NRCAGGTGYR
SELEX
Yin et al.(2017)
SNAI2_FL_Methyl-HT-SELEX
(Direct) (Direct)
SNAI2
M08853_2.00
Homo sapiens
NVCACCTGYY

RRCAGGTGBN
Misc
Kulakovskiy et al.(2013)
SNAI2_HUMAN.H11MO.0.A
(Direct) (Direct)
SNAI2
M10102_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_01
(Direct) (Direct)
SNAI2
M10103_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6_02
(Direct) (Direct)
SNAI2
M10104_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SLUG_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Snai2
M08973_2.00
Mus musculus
VNRCACCTGYY

RRCAGGTGYNB
Misc
Kulakovskiy et al.(2013)
SNAI2_MOUSE.H11MO.0.A
0.827 1.000
esg
M06050_2.00
Drosophila melanogaster
CACCTGH

DCAGGTG
B1H
Zhu et al.(2011)
esg_SANGER_2.5_FBgn0001981
0.767 0.816
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00220_2.00 C2H2 ZF 15 37
M00220_2.00 C2H2 ZF 46 68
M00220_2.00 C2H2 ZF 72 94
M00220_2.00 C2H2 ZF 100 122
M00220_2.00 C2H2 ZF 128 149
M00221_2.00 C2H2 ZF 15 37
M00221_2.00 C2H2 ZF 46 68
M00221_2.00 C2H2 ZF 72 94
M00221_2.00 C2H2 ZF 100 122
M00221_2.00 C2H2 ZF 128 149
M00222_2.00 C2H2 ZF 15 37
M00222_2.00 C2H2 ZF 46 68
M00222_2.00 C2H2 ZF 72 94
M00222_2.00 C2H2 ZF 100 122
M00222_2.00 C2H2 ZF 128 149

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000020945 C2H2 ZF 128 150
ENSP00000020945 C2H2 ZF 159 181
ENSP00000020945 C2H2 ZF 185 207
ENSP00000020945 C2H2 ZF 213 235
ENSP00000020945 C2H2 ZF 241 262
ENSP00000380034 C2H2 ZF 128 150
ENSP00000380034 C2H2 ZF 159 181
ENSP00000380034 C2H2 ZF 185 207
ENSP00000380034 C2H2 ZF 213 235
ENSP00000380034 C2H2 ZF 241 262

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

103 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000009606 Ailuropoda melanoleuca ENSAMEG00000009606 I 0.827
Alligator_sinensis_CCG016283.1 Alligator sinensis Alligator_sinensis_CCG016283.1 I 0.825
Alligator_sinensis_CCG001703.1 Alligator sinensis Alligator_sinensis_CCG001703.1 I 0.762
ENSAPLG00000003920 Anas platyrhynchos ENSAPLG00000003920 I 0.825
SNAI2 Anolis carolinensis ENSACAG00000012332 I 0.825
Afo_R005870 Aptenodytes forsteri Afo_R005870 I 0.825
ENSAMXG00000011013 Astyanax mexicanus ENSAMXG00000011013 I 0.783
ENSP00000020945-D1 Bos grunniens ENSP00000020945-D1 I 0.815
SNAI2 Bos taurus ENSBTAG00000013227 I 0.815
Brh_R006038 Buceros rhinoceros Brh_R006038 I 0.825
SNAI2 Callithrix jacchus ENSCJAG00000013499 I 0.827
Aan_R012932 Calypte anna Aan_R012932 I 0.825
SNAI2 Canis familiaris ENSCAFG00000006638 I 0.827
CapteG76255 Capitella teleta CapteG76255 I 0.767
ENSCPOG00000014827 Cavia porcellus ENSCPOG00000014827 I 0.827
Cmyd_10017446 Chelonia mydas Cmyd_10017446 I 0.756
ENSCSAG00000014787 Chlorocebus sabaeus ENSCSAG00000014787 I 0.827
SNAI2 Choloepus hoffmanni ENSCHOG00000007046 I 0.827
KGM_17970 Danaus plexippus KGM_17970 I 0.757
snai2 Danio rerio ENSDARG00000040046 I 0.803
SNAI2 Dasypus novemcinctus ENSDNOG00000035997 I 0.827
GF15382 Drosophila ananassae FBgn0092407 I 0.767
GG25158 Drosophila erecta FBgn0117283 I 0.767
GH13754 Drosophila grimshawi FBgn0121230 I 0.769
esg Drosophila melanogaster FBgn0001981 D 0.767
GI17894 Drosophila mojavensis FBgn0140635 I 0.769
GL26425 Drosophila persimilis FBgn0164007 I 0.767
GA17666 Drosophila pseudoobscura FBgn0077676 I 0.767
GD24004 Drosophila simulans FBgn0195364 I 0.757
GJ17399 Drosophila virilis FBgn0204571 I 0.769
GK18133 Drosophila willistoni FBgn0220132 I 0.769
GE20968 Drosophila yakuba FBgn0238253 I 0.767
SNAI2 Equus caballus ENSECAG00000010120 I 0.827
SNAI2 Felis catus ENSFCAG00000015779 I 0.827
ENSFALG00000005762 Ficedula albicollis ENSFALG00000005762 I 0.825
ENSGMOG00000002669 Gadus morhua ENSGMOG00000002669 I 0.805
ENSGALG00000015241 Gallus gallus ENSGALG00000015241 I 0.825
snai2 Gasterosteus aculeatus ENSGACG00000017935 I 0.803
Gfo_R012649 Geospiza fortis Gfo_R012649 I 0.825
SNAI2 Gorilla gorilla ENSGGOG00000000959 I 0.827
HMEL002306 Heliconius melpomene HMEL002306 I 0.757
ENSSTOG00000028743 Ictidomys tridecemlineatus ENSSTOG00000028743 I 0.827
ENSLACG00000005413 Latimeria chalumnae ENSLACG00000005413 I 0.823
ENSLACG00000017707 Latimeria chalumnae ENSLACG00000017707 I 0.756
ENSLACG00000004705 Latimeria chalumnae ENSLACG00000004705 I 0.778
ENSLOCG00000004887 Lepisosteus oculatus ENSLOCG00000004887 I 0.775
ENSLOCG00000005992 Lepisosteus oculatus ENSLOCG00000005992 I 0.805
LDEC001157 Leptinotarsa decemlineata LDEC001157 I 0.769
LotgiG114290 Lottia gigantea LotgiG114290 I 0.761
SNAI2 Loxodonta africana ENSLAFG00000009299 I 0.827
LCUP013268 Lucilia cuprina LCUP013268 I 0.772
ENSP00000380034 Macaca fascicularis ENSP00000380034 I 0.827
SNAI2 Macaca mulatta ENSMMUG00000016195 I 0.827
ENSMEUG00000009510 Macropus eugenii ENSMEUG00000009510 I 0.821
SNAI2 Meleagris gallopavo ENSMGAG00000010813 I 0.825
MCINX001355 Melitaea cinxia MCINX001355 I 0.757
SNAI2 Microcebus murinus ENSMICG00000000335 I 0.827
SNAI2 Monodelphis domestica ENSMODG00000010173 I 0.825
MDOA014024 Musca domestica MDOA014024 I 0.772
ENSMPUG00000010793 Mustela putorius furo ENSMPUG00000010793 I 0.827
Snai2 Mus musculus ENSMUSG00000022676 D 0.827
Myotis_brandtii_Snai2_10018131 Myotis brandtii Myotis_brandtii_Snai2_10018131 I 0.827
SNAI2 Myotis lucifugus ENSMLUG00000001086 I 0.827
ENSNLEG00000013421 Nomascus leucogenys ENSNLEG00000013421 I 0.827
Ogr04681 Ophisaurus gracilis Ogr04681 I 0.825
ENSONIG00000009542 Oreochromis niloticus ENSONIG00000009542 I 0.805
SNAI2 Ornithorhynchus anatinus ENSOANG00000007267 I 0.825
SNAI2 Oryctolagus cuniculus ENSOCUG00000012254 I 0.827
snai2 Oryzias latipes ENSORLG00000017475 I 0.805
SNAI2 Otolemur garnettii ENSOGAG00000010500 I 0.827
ENSOARG00000013030 Ovis aries ENSOARG00000013030 I 0.815
SNAI2 Pan troglodytes ENSPTRG00000020235 I 0.827
ENSPANG00000017540 Papio anubis ENSPANG00000017540 I 0.827
ENSPSIG00000003607 Pelodiscus sinensis ENSPSIG00000003607 I 0.756
ENSPSIG00000016395 Pelodiscus sinensis ENSPSIG00000016395 I 0.825
PPAI008011 Phlebotomus papatasi PPAI008011 I 0.756
ENSPFOG00000014336 Poecilia formosa ENSPFOG00000014336 I 0.803
Pvit_15376 Pogona vitticeps Pvit_15376 I 0.825
ENSPPYG00000018578 Pongo abelii ENSPPYG00000018578 I 0.827
SNAI2 Procavia capensis ENSPCAG00000001788 I 0.827
SNAI2 Pteropus vampyrus ENSPVAG00000009457 I 0.825
Snai2 Rattus norvegicus ENSRNOG00000047699 I 0.827
Sakowv30043351m.g Saccoglossus kowalevskii Sakowv30043351m.g I 0.764
ENSSHAG00000004205 Sarcophilus harrisii ENSSHAG00000004205 I 0.825
ENSSSCG00000024404 Sus scrofa ENSSSCG00000024404 I 0.819
ENSSSCG00000026570 Sus scrofa ENSSSCG00000026570 I 0.819
SNAI2 Taeniopygia guttata ENSTGUG00000010914 I 0.825
snai2 Takifugu rubripes ENSTRUG00000006860 I 0.805
snai2 Tetraodon nigroviridis ENSTNIG00000008504 I 0.805
TC014474 Tribolium castaneum TC014474 I 0.767
Tal_R003673 Tyto alba Tal_R003673 I 0.825
snai2.S Xenopus laevis XB-GENE-865699 I 0.825
snai1.S Xenopus laevis XB-GENE-865328 I 0.761
snai2.L Xenopus laevis XB-GENE-6255814 I 0.825
AAB34088 Xenopus laevis AAB34088 I 0.825
AAK54139 Xenopus laevis AAK54139 I 0.825
AAK54137 Xenopus laevis AAK54137 I 0.825
snai2 Xenopus tropicalis XB-GENE-487371 I 0.825
AAK54135 Xenopus tropicalis AAK54135 I 0.825
snai1 Xenopus tropicalis XB-GENE-479970 I 0.761
ENSXMAG00000019030 Xiphophorus maculatus ENSXMAG00000019030 I 0.803
L798_10614 Zootermopsis nevadensis L798_10614 I 0.757