IKZF2 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000030419 T094785_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
(Direct) (Direct)
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Mus musculus

Kulakovskiy et al.(2013)
0.804 0.924
Homo sapiens

Kulakovskiy et al.(2013)
0.804 0.913
Homo sapiens

Matys et al.(2006)
0.804 0.913
Homo sapiens

Matys et al.(2006)
0.804 0.913
Homo sapiens

Matys et al.(2006)
0.804 0.913
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
0.804 0.913
Homo sapiens Transfac license required
Transfac license required
Matys et al.(2006)
0.804 0.913
Homo sapiens

Matys et al.(2006)
0.804 0.913
Homo sapiens

Schmitges et al.(2016)
0.776 0.837
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000342876 C2H2 ZF 118 140
ENSP00000342876 C2H2 ZF 146 168
ENSP00000342876 C2H2 ZF 174 196
ENSP00000342876 C2H2 ZF 202 225
ENSP00000363439 C2H2 ZF 114 136
ENSP00000363439 C2H2 ZF 142 164
ENSP00000363439 C2H2 ZF 170 193
ENSP00000395203 C2H2 ZF 71 93
ENSP00000395203 C2H2 ZF 99 121
ENSP00000395203 C2H2 ZF 127 150
ENSP00000396253 C2H2 ZF 112 134
ENSP00000396253 C2H2 ZF 140 162
ENSP00000396253 C2H2 ZF 168 190
ENSP00000396253 C2H2 ZF 196 219
ENSP00000410447 C2H2 ZF 71 93
ENSP00000410447 C2H2 ZF 99 121
ENSP00000412869 C2H2 ZF 112 134
ENSP00000412869 C2H2 ZF 140 162
ENSP00000412869 C2H2 ZF 168 190
ENSP00000412869 C2H2 ZF 196 219


Other C2H2 ZF family TFs
Other Homo sapiens TFs

229 Related TFs

Name Species Gene ID Motif Evidence SR
IKZF3 Homo sapiens ENSG00000161405 D 0.796
IKZF1 Homo sapiens ENSG00000185811 D 0.804
Ikzf1 Mus musculus ENSMUSG00000018654 D 0.804
IKZF3 Pteropus vampyrus ENSPVAG00000008536 I 0.776
IKZF4 Pteropus vampyrus ENSPVAG00000007558 I 0.757
IKZF1 Pan troglodytes ENSPTRG00000019187 I 0.804
IKZF2 Pan troglodytes ENSPTRG00000012884 I 0.827
IKZF3 Pan troglodytes ENSPTRG00000009103 I 0.776
IKZF4 Pan troglodytes ENSPTRG00000005074 I 0.757
ENSPSIG00000016492 Pelodiscus sinensis ENSPSIG00000016492 I 0.813
ENSPSIG00000014940 Pelodiscus sinensis ENSPSIG00000014940 I 0.827
ENSPSIG00000009682 Pelodiscus sinensis ENSPSIG00000009682 I 0.776
ENSPPYG00000017561 Pongo abelii ENSPPYG00000017561 I 0.804
IKZF1 Pteropus vampyrus ENSPVAG00000010570 I 0.804
IKZF2 Pteropus vampyrus ENSPVAG00000014197 I 0.827
ENSSTOG00000003804 Ictidomys tridecemlineatus ENSSTOG00000003804 I 0.776
ENSSTOG00000003579 Ictidomys tridecemlineatus ENSSTOG00000003579 I 0.804
ENSSSCG00000029806 Sus scrofa ENSSSCG00000029806 I 0.804
IKZF3 Sus scrofa ENSSSCG00000017494 I 0.776
IKZF2 Sus scrofa ENSSSCG00000016164 I 0.827
ENSSHAG00000016773 Sarcophilus harrisii ENSSHAG00000016773 I 0.804
ENSSHAG00000014629 Sarcophilus harrisii ENSSHAG00000014629 I 0.776
Ikzf2 Rattus norvegicus ENSRNOG00000027430 I 0.827
Ikzf3 Rattus norvegicus ENSRNOG00000007200 I 0.776
Ikzf4 Rattus norvegicus ENSRNOG00000005535 I 0.757
Ikzf1 Rattus norvegicus ENSRNOG00000004444 I 0.804
ENSPPYG00000013139 Pongo abelii ENSPPYG00000013139 I 0.827
ENSPPYG00000008476 Pongo abelii ENSPPYG00000008476 I 0.776
ENSPPYG00000004641 Pongo abelii ENSPPYG00000004641 I 0.757
ENSONIG00000009010 Oreochromis niloticus ENSONIG00000009010 I 0.768
IKZF4 Otolemur garnettii ENSOGAG00000034375 I 0.757
IKZF2 Otolemur garnettii ENSOGAG00000016680 I 0.827
IKZF3 Otolemur garnettii ENSOGAG00000007067 I 0.776
IKZF1 Otolemur garnettii ENSOGAG00000005868 I 0.804
IKZF1 Oryctolagus cuniculus ENSOCUG00000014423 I 0.807
IKZF4 Oryctolagus cuniculus ENSOCUG00000012558 I 0.757
IKZF2 Oryctolagus cuniculus ENSOCUG00000007309 I 0.827
IKZF3 Oryctolagus cuniculus ENSOCUG00000001355 I 0.776
ENSOARG00000019252 Ovis aries ENSOARG00000019252 I 0.827
ENSOARG00000014822 Ovis aries ENSOARG00000014822 I 0.807
ENSONIG00000010379 Oreochromis niloticus ENSONIG00000010379 I 0.801
IKZF4 Ochotona princeps ENSOPRG00000007904 I 0.757
ENSOPRG00000009026 Ochotona princeps ENSOPRG00000009026 I 0.776
ENSPMAG00000001307 Petromyzon marinus ENSPMAG00000001307 I 0.780
ENSPFOG00000013807 Poecilia formosa ENSPFOG00000013807 I 0.758
ENSPFOG00000013073 Poecilia formosa ENSPFOG00000013073 I 0.801
ENSPFOG00000002235 Poecilia formosa ENSPFOG00000002235 I 0.801
IKZF4 Procavia capensis ENSPCAG00000010641 I 0.757
IKZF1 Procavia capensis ENSPCAG00000008500 I 0.804
ENSPANG00000021743 Papio anubis ENSPANG00000021743 I 0.776
ENSPANG00000016694 Papio anubis ENSPANG00000016694 I 0.827
ENSPANG00000005244 Papio anubis ENSPANG00000005244 I 0.804
IKZF3 Oryzias latipes ENSORLG00000002674 I 0.803
IKZF1 Ochotona princeps ENSOPRG00000010757 I 0.807
ENSOARG00000012131 Ovis aries ENSOARG00000012131 I 0.776
XP_002940416 Xenopus tropicalis XP_002940416 I 0.763
ENSP00000342876 Macaca fascicularis ENSP00000342876 I 0.827
ENSP00000342876-D1 Bos grunniens ENSP00000342876-D1 I 0.827
ENSP00000331614 Macaca fascicularis ENSP00000331614 I 0.804
ENSP00000262032 Macaca fascicularis ENSP00000262032 I 0.757
ENSP00000262032-D1 Bos grunniens ENSP00000262032-D1 I 0.757
ENSBTAP00000018632-D1 Bos grunniens ENSBTAP00000018632-D1 I 0.807
Cmyd_10015871 Chelonia mydas Cmyd_10015871 I 0.776
Cmyd_10012463 Chelonia mydas Cmyd_10012463 I 0.813
Cmyd_10006949 Chelonia mydas Cmyd_10006949 I 0.827
Brh_R013134 Buceros rhinoceros Brh_R013134 I 0.804
Brh_R006187 Buceros rhinoceros Brh_R006187 I 0.776
ENSP00000418684-D1 Bos grunniens ENSP00000418684-D1 I 0.776
ENSP00000418684 Macaca fascicularis ENSP00000418684 I 0.776
Gfo_R009614 Geospiza fortis Gfo_R009614 I 0.804
ikzf2.S Xenopus laevis XB-GENE-17346220 I 0.812
ikzf2 Xenopus tropicalis XB-GENE-1013632 I 0.827
Tal_R003737 Tyto alba Tal_R003737 I 0.804
Tal_R002368 Tyto alba Tal_R002368 I 0.827
Pvit_18490 Pogona vitticeps Pvit_18490 I 0.807
Pvit_13083 Pogona vitticeps Pvit_13083 I 0.827
Pvit_07651 Pogona vitticeps Pvit_07651 I 0.785
Ogr12798 Ophisaurus gracilis Ogr12798 I 0.804
Myotis_brandtii_IKZF4_10009162 Myotis brandtii Myotis_brandtii_IKZF4_10009162 I 0.757
Gfo_R016268 Geospiza fortis Gfo_R016268 I 0.773
Gfo_R012078 Geospiza fortis Gfo_R012078 I 0.827
Brh_R001017 Buceros rhinoceros Brh_R001017 I 0.827
Alligator_sinensis_CCG020787.1 Alligator sinensis Alligator_sinensis_CCG020787.1 I 0.776
Alligator_sinensis_CCG019297.1 Alligator sinensis Alligator_sinensis_CCG019297.1 I 0.801
IKZF3 Takifugu rubripes ENSTRUG00000005964 I 0.768
ENSTNIG00000014148 Tetraodon nigroviridis ENSTNIG00000014148 I 0.770
ikzf1 Tetraodon nigroviridis ENSTNIG00000004159 I 0.789
IKZF1 Taeniopygia guttata ENSTGUG00000007910 I 0.804
IKZF2 Taeniopygia guttata ENSTGUG00000002874 I 0.827
IKZF3 Taeniopygia guttata ENSTGUG00000002245 I 0.773
IKZF3 Tupaia belangeri ENSTBEG00000012590 I 0.776
IKZF2 Tupaia belangeri ENSTBEG00000010122 I 0.827
IKZF1 Tupaia belangeri ENSTBEG00000004896 I 0.801
ENSSTOG00000011683 Ictidomys tridecemlineatus ENSSTOG00000011683 I 0.827
ENSSTOG00000010547 Ictidomys tridecemlineatus ENSSTOG00000010547 I 0.757
ikzf1 Takifugu rubripes ENSTRUG00000017779 I 0.816
IKZF1 Tursiops truncatus ENSTTRG00000007440 I 0.797
IKZF3 Tursiops truncatus ENSTTRG00000008224 I 0.776
Afo_R015511 Aptenodytes forsteri Afo_R015511 I 0.773
Afo_R007273 Aptenodytes forsteri Afo_R007273 I 0.827
Afo_R002924 Aptenodytes forsteri Afo_R002924 I 0.804
Aan_R015421 Calypte anna Aan_R015421 I 0.827
Aan_R006146 Calypte anna Aan_R006146 I 0.776
Aan_R005612 Calypte anna Aan_R005612 I 0.757
Aan_R002806 Calypte anna Aan_R002806 I 0.804
ENSXMAG00000018173 Xiphophorus maculatus ENSXMAG00000018173 I 0.758
ENSXMAG00000008077 Xiphophorus maculatus ENSXMAG00000008077 I 0.801
IKZF2 Vicugna pacos ENSVPAG00000004262 I 0.827
IKZF3 Vicugna pacos ENSVPAG00000001706 I 0.776
ENSTSYG00000006472 Tarsius syrichta ENSTSYG00000006472 I 0.827
ENSOARG00000010565 Ovis aries ENSOARG00000010565 I 0.757
IKZF1 Gallus gallus ENSGALG00000013086 I 0.804
IKZF4 Erinaceus europaeus ENSEEUG00000006871 I 0.757
IKZF2 Erinaceus europaeus ENSEEUG00000001089 I 0.827
IKZF4 Equus caballus ENSECAG00000024175 I 0.757
IKZF1 Equus caballus ENSECAG00000018339 I 0.807
IKZF3 Equus caballus ENSECAG00000007441 I 0.776
Ikzf4 Dipodomys ordii ENSDORG00000015397 I 0.757
Ikzf2 Dipodomys ordii ENSDORG00000007539 I 0.827
IKZF4 Dasypus novemcinctus ENSDNOG00000037824 I 0.757
IKZF3 Dasypus novemcinctus ENSDNOG00000015682 I 0.776
IKZF1 Dasypus novemcinctus ENSDNOG00000000179 I 0.804
ikzf1 Danio rerio ENSDARG00000013539 I 0.804
IKZF3 Echinops telfairi ENSETEG00000005889 I 0.776
IKZF2 Echinops telfairi ENSETEG00000019814 I 0.827
IKZF2 Gallus gallus ENSGALG00000003136 I 0.827
IKZF3 Gasterosteus aculeatus ENSGACG00000018123 I 0.768
ikzf1 Gasterosteus aculeatus ENSGACG00000003033 I 0.801
IKZF4 Homo sapiens ENSG00000123411 I 0.757
IKZF3 Felis catus ENSFCAG00000030732 I 0.776
IKZF4 Felis catus ENSFCAG00000029852 I 0.757
IKZF1 Felis catus ENSFCAG00000018516 I 0.807
IKZF2 Felis catus ENSFCAG00000009654 I 0.827
ENSFALG00000012948 Ficedula albicollis ENSFALG00000012948 I 0.827
ENSFALG00000007512 Ficedula albicollis ENSFALG00000007512 I 0.804
ENSFALG00000000489 Ficedula albicollis ENSFALG00000000489 I 0.773
ENSCSAG00000016006 Chlorocebus sabaeus ENSCSAG00000016006 I 0.804
ENSCSAG00000005270 Chlorocebus sabaeus ENSCSAG00000005270 I 0.757
IKZF4 Bos taurus ENSBTAG00000012636 I 0.757
IKZF3 Bos taurus ENSBTAG00000011003 I 0.776
ENSAPLG00000015016 Anas platyrhynchos ENSAPLG00000015016 I 0.773
ENSAPLG00000003006 Anas platyrhynchos ENSAPLG00000003006 I 0.804
ENSAMXG00000001814 Astyanax mexicanus ENSAMXG00000001814 I 0.801
ENSAMEG00000009888 Ailuropoda melanoleuca ENSAMEG00000009888 I 0.776
ENSAMEG00000008058 Ailuropoda melanoleuca ENSAMEG00000008058 I 0.827
ENSAMEG00000008051 Ailuropoda melanoleuca ENSAMEG00000008051 I 0.807
ENSAMEG00000003228 Ailuropoda melanoleuca ENSAMEG00000003228 I 0.757
IKZF2 Anolis carolinensis ENSACAG00000025864 I 0.827
IKZF1 Anolis carolinensis ENSACAG00000008236 I 0.807
IKZF1 Canis familiaris ENSCAFG00000003374 I 0.807
IKZF2 Canis familiaris ENSCAFG00000014224 I 0.827
ENSCSAG00000002731 Chlorocebus sabaeus ENSCSAG00000002731 I 0.776
IKZF2 Cavia porcellus ENSCPOG00000013506 I 0.827
IKZF4 Cavia porcellus ENSCPOG00000009964 I 0.757
ENSCPOG00000007605 Cavia porcellus ENSCPOG00000007605 I 0.804
ENSCPOG00000005792 Cavia porcellus ENSCPOG00000005792 I 0.776
IKZF2 Callithrix jacchus ENSCJAG00000011409 I 0.827
IKZF1 Callithrix jacchus ENSCJAG00000010988 I 0.804
IKZF3 Callithrix jacchus ENSCJAG00000008957 I 0.796
IKZF4 Callithrix jacchus ENSCJAG00000006230 I 0.757
IKZF4 Canis familiaris ENSCAFG00000030801 I 0.757
IKZF3 Canis familiaris ENSCAFG00000016310 I 0.776
IKZF3 Anolis carolinensis ENSACAG00000003308 I 0.775
IKZF3 Ornithorhynchus anatinus ENSOANG00000003623 I 0.776
IKZF4 Macaca mulatta ENSMMUG00000007523 I 0.757
IKZF1 Macaca mulatta ENSMMUG00000000504 I 0.804
IKZF2 Macaca mulatta ENSMMUG00000000381 I 0.827
IKZF4 Myotis lucifugus ENSMLUG00000026014 I 0.757
IKZF2 Myotis lucifugus ENSMLUG00000012494 I 0.827
IKZF3 Myotis lucifugus ENSMLUG00000003323 I 0.776
IKZF1 Myotis lucifugus ENSMLUG00000003135 I 0.804
IKZF2 Microcebus murinus ENSMICG00000013862 I 0.827
IKZF4 Microcebus murinus ENSMICG00000011029 I 0.757
IKZF3 Microcebus murinus ENSMICG00000010571 I 0.776
ENSMGAG00000010066 Meleagris gallopavo ENSMGAG00000010066 I 0.757
IKZF3 Macaca mulatta ENSMMUG00000017337 I 0.796
IKZF1 Bos taurus ENSBTAG00000014016 I 0.807
IKZF1 Monodelphis domestica ENSMODG00000009274 I 0.804
IKZF1 Ornithorhynchus anatinus ENSOANG00000000286 I 0.804
ENSNLEG00000017564 Nomascus leucogenys ENSNLEG00000017564 I 0.757
ENSNLEG00000007199 Nomascus leucogenys ENSNLEG00000007199 I 0.827
ENSNLEG00000001118 Nomascus leucogenys ENSNLEG00000001118 I 0.776
Ikzf2 Mus musculus ENSMUSG00000025997 I 0.827
Ikzf3 Mus musculus ENSMUSG00000018168 I 0.776
Ikzf4 Mus musculus ENSMUSG00000002578 I 0.757
ENSMPUG00000018161 Mustela putorius furo ENSMPUG00000018161 I 0.807
ENSMPUG00000014968 Mustela putorius furo ENSMPUG00000014968 I 0.776
ENSMPUG00000000964 Mustela putorius furo ENSMPUG00000000964 I 0.757
IKZF3 Monodelphis domestica ENSMODG00000012901 I 0.776
IKZF1 Meleagris gallopavo ENSMGAG00000006477 I 0.804
IKZF3 Gallus gallus ENSGALG00000013481 I 0.776
ENSLOCG00000004967 Lepisosteus oculatus ENSLOCG00000004967 I 0.804
IKZF4 Gorilla gorilla ENSGGOG00000011558 I 0.757
ENSGMOG00000005918 Gadus morhua ENSGMOG00000005918 I 0.804
ENSGMOG00000012959 Gadus morhua ENSGMOG00000012959 I 0.765
IKZF4 Loxodonta africana ENSLAFG00000026742 I 0.757
IKZF2 Loxodonta africana ENSLAFG00000008236 I 0.827
ENSLACG00000011419 Latimeria chalumnae ENSLACG00000011419 I 0.775
IKZF3 Loxodonta africana ENSLAFG00000000289 I 0.776
ENSLACG00000011807 Latimeria chalumnae ENSLACG00000011807 I 0.804
ENSLOCG00000013557 Lepisosteus oculatus ENSLOCG00000013557 I 0.768
IKZF2 Gorilla gorilla ENSGGOG00000011301 I 0.827
IKZF3 Gorilla gorilla ENSGGOG00000009814 I 0.776
ENSMEUG00000000683 Macropus eugenii ENSMEUG00000000683 I 0.827
ENSMGAG00000003697 Meleagris gallopavo ENSMGAG00000003697 I 0.827
IKZF1 Gorilla gorilla ENSGGOG00000004969 I 0.804
IKZF3 Meleagris gallopavo ENSMGAG00000002822 I 0.773
ikzf1 Xenopus tropicalis XB-GENE-876522 N 0.800
IKZF1 Sorex araneus ENSSARG00000012665 N 0.800
Myotis_brandtii_IKZF2_10022929 Myotis brandtii Myotis_brandtii_IKZF2_10022929 N 0.827
IKZF2 Sorex araneus ENSSARG00000012607 N 0.827
IKZF3 Sorex araneus ENSSARG00000000678 N 0.792
IKZF2 Monodelphis domestica ENSMODG00000015683 N 0.827
IKZF4 Monodelphis domestica ENSMODG00000001780 N 0.827
IKZF2 Bos taurus ENSBTAG00000037804 N 0.827
ENSDORG00000010394 Dipodomys ordii ENSDORG00000010394 N 0.800
ENSMICG00000002334 Microcebus murinus ENSMICG00000002334 N 0.800
IKZF2 Equus caballus ENSECAG00000000040 N 0.827
ENSCSAG00000009405 Chlorocebus sabaeus ENSCSAG00000009405 N 0.827
ENSMEUG00000014645 Macropus eugenii ENSMEUG00000014645 N 0.800
IKZF2 Tursiops truncatus ENSTTRG00000003213 N 0.827
ENSTSYG00000007372 Tarsius syrichta ENSTSYG00000007372 N 0.800
ENSCJAG00000033095 Callithrix jacchus ENSCJAG00000033095 N 0.792
si:zfos-1425h8.1 Takifugu rubripes ENSTRUG00000014740 N 0.802
ikzf1 Oryzias latipes ENSORLG00000020562 N 0.797
si:zfos-1425h8.1 Oryzias latipes ENSORLG00000016031 N 0.802
IKZF1 Echinops telfairi ENSETEG00000011408 N 0.800
ENSDORG00000002620 Dipodomys ordii ENSDORG00000002620 N 0.796