PRDM1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000057657 T094789_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PRDM1
M02731_2.00
Homo sapiens
YACTTTCACTTT

AAAGTGAAAGTR
SELEX
Jolma et al.(2010)
PRDM1_dimer
(Direct) (Direct)
PRDM1
M02874_2.00
Homo sapiens
NHACTTTCACTTTYN

NRAAAGTGAAAGTDN
SELEX
Jolma et al.(2013)
PRDM1_1
(Direct) (Direct)
PRDM1
M04396_2.00
Homo sapiens
NYACTTTCVCYN

NRGBGAAAGTRN
SELEX
Yin et al.(2017)
PRDM1_eDBD_HT-SELEX
(Direct) (Direct)
PRDM1
M04397_2.00
Homo sapiens
NCACTTTCVCYN

NRGBGAAAGTGN
SELEX
Yin et al.(2017)
PRDM1_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
PRDM1
M07845_2.00
Homo sapiens
NHACTTTCHCTTHYN

NRDAAGDGAAAGTDN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_PRDM1_Stanford
(Direct) (Direct)
PRDM1
M08083_2.00
Homo sapiens
NHACTTTCHY

RDGAAAGTDN
ChIP-seq
Mathelier et al.(2014)
MA0508.2
(Direct) (Direct)
PRDM1
M08191_2.00
Homo sapiens
ACTTTCAC

GTGAAAGT
ChIP-seq
Contrino et al.(2012)
Mv110
(Direct) (Direct)
PRDM1
M08192_2.00
Homo sapiens
HRTCACTTT

AAAGTGAYD
ChIP-seq
Contrino et al.(2012)
Mv112
(Direct) (Direct)
PRDM1
M08276_2.00
Homo sapiens
HHNBYVCTTTCHCYY

RRGDGAAAGBRVNDD
ChIP-seq
Schmitges et al.(2016)
O75626.MEME
(Direct) (Direct)
PRDM1
M08854_2.00
Homo sapiens
NNACTTTCHCTTYY

RRAAGDGAAAGTNN
Misc
Kulakovskiy et al.(2013)
PRDM1_HUMAN.H11MO.0.A
(Direct) (Direct)
PRDM1
M09500_2.00
Homo sapiens
ACTTTCHCTKNN

NNMAGDGAAAGT
Misc
Heinz et al.(2010)
Hela-PRDM1_GSE31477
(Direct) (Direct)
PRDM1
M10108_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BLIMP1_Q4
(Direct) (Direct)
PRDM1
M10109_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BLIMP1_Q6_01
(Direct) (Direct)
PRDM1
M10110_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BLIMP1_Q6
(Direct) (Direct)
PRDM1
M10111_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRDM1_03
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Prdm1
M08995_2.00
Mus musculus
NNACTTTCHCTTYY

RRAAGDGAAAGTNN
Misc
Kulakovskiy et al.(2013)
PRDM1_MOUSE.H11MO.0.A
0.825 0.982
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000358085 C2H2 ZF 441 463
ENSP00000358085 C2H2 ZF 469 491
ENSP00000358085 C2H2 ZF 497 519
ENSP00000358085 C2H2 ZF 525 547
ENSP00000358085 C2H2 ZF 553 574
ENSP00000358087 C2H2 ZF 539 561
ENSP00000358087 C2H2 ZF 567 589
ENSP00000358087 C2H2 ZF 595 617
ENSP00000358087 C2H2 ZF 623 645
ENSP00000358087 C2H2 ZF 651 672
ENSP00000358092 C2H2 ZF 575 597
ENSP00000358092 C2H2 ZF 603 625
ENSP00000358092 C2H2 ZF 631 653
ENSP00000358092 C2H2 ZF 659 681
ENSP00000358092 C2H2 ZF 687 708
ENSP00000478294 C2H2 ZF 538 560
ENSP00000478294 C2H2 ZF 566 588
ENSP00000478294 C2H2 ZF 594 616
ENSP00000478294 C2H2 ZF 622 644
ENSP00000478294 C2H2 ZF 650 671

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

43 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PRDM1 Pan troglodytes ENSPTRG00000018457 I 0.827
PRDM1 Macaca mulatta ENSMMUG00000021401 I 0.827
ENSNLEG00000013211 Nomascus leucogenys ENSNLEG00000013211 I 0.827
ENSPPYG00000016879 Pongo abelii ENSPPYG00000016879 I 0.827
ENSPANG00000016727 Papio anubis ENSPANG00000016727 I 0.827
PRDM1 Gorilla gorilla ENSGGOG00000001929 I 0.827
ENSCSAG00000014744 Chlorocebus sabaeus ENSCSAG00000014744 I 0.827
ENSP00000358092 Macaca fascicularis ENSP00000358092 I 0.827
PRDM1 Tupaia belangeri ENSTBEG00000004089 I 0.825
Prdm1 Mus musculus ENSMUSG00000038151 D 0.825
PRDM1 Callithrix jacchus ENSCJAG00000006332 I 0.825
PRDM1 Otolemur garnettii ENSOGAG00000014036 I 0.825
PRDM1 Microcebus murinus ENSMICG00000010329 I 0.825
Prdm1 Rattus norvegicus ENSRNOG00000000323 I 0.825
ENSSTOG00000016505 Ictidomys tridecemlineatus ENSSTOG00000016505 I 0.825
ENSTSYG00000011666 Tarsius syrichta ENSTSYG00000011666 I 0.825
PRDM1 Ochotona princeps ENSOPRG00000006055 I 0.825
PRDM1 Loxodonta africana ENSLAFG00000013436 I 0.825
Myotis_brandtii_PRDM1_10034696 Myotis brandtii Myotis_brandtii_PRDM1_10034696 I 0.823
PRDM1 Sus scrofa ENSSSCG00000004369 I 0.823
PRDM1 Pteropus vampyrus ENSPVAG00000011732 I 0.823
PRDM1 Sorex araneus ENSSARG00000004079 I 0.823
PRDM1 Tursiops truncatus ENSTTRG00000012894 I 0.823
PRDM1 Ornithorhynchus anatinus ENSOANG00000004176 I 0.823
PRDM1 Erinaceus europaeus ENSEEUG00000013222 I 0.823
PRDM1 Equus caballus ENSECAG00000009044 I 0.823
PRDM1 Canis familiaris ENSCAFG00000003694 I 0.823
PRDM1 Myotis lucifugus ENSMLUG00000014085 I 0.823
PRDM1 Felis catus ENSFCAG00000010755 I 0.823
ENSAMEG00000001482 Ailuropoda melanoleuca ENSAMEG00000001482 I 0.823
ENSMPUG00000009522 Mustela putorius furo ENSMPUG00000009522 I 0.823
ENSMEUG00000000043 Macropus eugenii ENSMEUG00000000043 I 0.821
Cmyd_10006231 Chelonia mydas Cmyd_10006231 I 0.820
Alligator_sinensis_CCG010485.1 Alligator sinensis Alligator_sinensis_CCG010485.1 I 0.820
ENSPSIG00000002661 Pelodiscus sinensis ENSPSIG00000002661 I 0.820
ENSSHAG00000010080 Sarcophilus harrisii ENSSHAG00000010080 I 0.819
PRDM1 Echinops telfairi ENSETEG00000019669 I 0.817
PRDM1 Cavia porcellus ENSCPOG00000014064 I 0.817
PRDM1 Oryctolagus cuniculus ENSOCUG00000015495 I 0.817
PRDM1 Monodelphis domestica ENSMODG00000018029 I 0.811
ENSAMXG00000004952 Astyanax mexicanus ENSAMXG00000004952 I 0.784
ENSTNIG00000012300 Tetraodon nigroviridis ENSTNIG00000012300 I 0.765