MECOM (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000085276 T094812_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MECOM
M08862_2.00
Homo sapiens
HNTNTTATCTTRTCWN

NWGAYAAGATAANAND
Misc
Kulakovskiy et al.(2013)
EVI1_HUMAN.H11MO.0.B
(Direct) (Direct)
MECOM
M10125_2.00
Homo sapiens
TTATCTTATCTTRTCW

WGAYAAGATAAGATAA
Transfac
Matys et al.(2006)
V$EVI1_01
(Direct) (Direct)
MECOM
M10126_2.00
Homo sapiens
TTATCTTRTCH

DGAYAAGATAA
Transfac
Matys et al.(2006)
V$EVI1_02
(Direct) (Direct)
MECOM
M10127_2.00
Homo sapiens
TTATCTTATCT

AGATAAGATAA
Transfac
Matys et al.(2006)
V$EVI1_03
(Direct) (Direct)
MECOM
M10128_2.00
Homo sapiens
TAWYYWDWYHTATYH

DRATADRAHWRRAWA
Transfac
Matys et al.(2006)
V$EVI1_04
(Direct) (Direct)
MECOM
M10129_2.00
Homo sapiens
HTATCTTATCT

AGATAAGATAD
Transfac
Matys et al.(2006)
V$EVI1_05
(Direct) (Direct)
MECOM
M10130_2.00
Homo sapiens
TTATCTTGT

ACAAGATAA
Transfac
Matys et al.(2006)
V$EVI1_06
(Direct) (Direct)
MECOM
M10131_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EVI1_Q3
(Direct) (Direct)
MECOM
M10132_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EVI_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mecom
M02667_2.00
Mus musculus
KNTTATCTTRTCTH

DAGAYAAGATAANM
SELEX
Mathelier et al.(2014)
MA0029.1
0.822 0.978
Mecom
M08980_2.00
Mus musculus
HNTNTTATCTTRTCWN

NWGAYAAGATAANAND
Misc
Kulakovskiy et al.(2013)
EVI1_MOUSE.H11MO.0.B
0.822 0.978
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264674 C2H2 ZF 85 106
ENSP00000264674 C2H2 ZF 139 161
ENSP00000264674 C2H2 ZF 167 189
ENSP00000264674 C2H2 ZF 195 219
ENSP00000264674 C2H2 ZF 225 247
ENSP00000264674 C2H2 ZF 253 275
ENSP00000264674 C2H2 ZF 282 303
ENSP00000264674 C2H2 ZF 798 820
ENSP00000264674 C2H2 ZF 826 849
ENSP00000264674 C2H2 ZF 855 877
ENSP00000394302 C2H2 ZF 21 42
ENSP00000394302 C2H2 ZF 75 97
ENSP00000394302 C2H2 ZF 103 125
ENSP00000394302 C2H2 ZF 131 155
ENSP00000394302 C2H2 ZF 161 183
ENSP00000394302 C2H2 ZF 189 211
ENSP00000394302 C2H2 ZF 218 239
ENSP00000394302 C2H2 ZF 734 756
ENSP00000394302 C2H2 ZF 762 785
ENSP00000394302 C2H2 ZF 791 813
ENSP00000417299 C2H2 ZF 21 42
ENSP00000417299 C2H2 ZF 75 97
ENSP00000417299 C2H2 ZF 103 125
ENSP00000417506 C2H2 ZF 50 72
ENSP00000417506 C2H2 ZF 78 100
ENSP00000417506 C2H2 ZF 106 129
ENSP00000417506 C2H2 ZF 135 157
ENSP00000417899 C2H2 ZF 209 230
ENSP00000417899 C2H2 ZF 263 285
ENSP00000417899 C2H2 ZF 291 313
ENSP00000417899 C2H2 ZF 319 342
ENSP00000417899 C2H2 ZF 348 370
ENSP00000417899 C2H2 ZF 376 398
ENSP00000417899 C2H2 ZF 405 426
ENSP00000417899 C2H2 ZF 912 934
ENSP00000417899 C2H2 ZF 940 963
ENSP00000417899 C2H2 ZF 969 991
ENSP00000417922 C2H2 ZF 21 42
ENSP00000417922 C2H2 ZF 75 97
ENSP00000418828 C2H2 ZF 21 42
ENSP00000419757 C2H2 ZF 21 42
ENSP00000419757 C2H2 ZF 75 97
ENSP00000419770 C2H2 ZF 21 42
ENSP00000419770 C2H2 ZF 75 97
ENSP00000419770 C2H2 ZF 103 125
ENSP00000419770 C2H2 ZF 131 154
ENSP00000419770 C2H2 ZF 160 182
ENSP00000419770 C2H2 ZF 188 210
ENSP00000419770 C2H2 ZF 217 238
ENSP00000419770 C2H2 ZF 724 746
ENSP00000419770 C2H2 ZF 752 775
ENSP00000419770 C2H2 ZF 781 803
ENSP00000419995 C2H2 ZF 21 42
ENSP00000419995 C2H2 ZF 75 97
ENSP00000419995 C2H2 ZF 103 125
ENSP00000419995 C2H2 ZF 131 154
ENSP00000419995 C2H2 ZF 160 182
ENSP00000419995 C2H2 ZF 188 210
ENSP00000419995 C2H2 ZF 217 238
ENSP00000419995 C2H2 ZF 733 755
ENSP00000419995 C2H2 ZF 761 784
ENSP00000419995 C2H2 ZF 790 812
ENSP00000420048 C2H2 ZF 21 42
ENSP00000420048 C2H2 ZF 75 97
ENSP00000420048 C2H2 ZF 103 125
ENSP00000420048 C2H2 ZF 131 155
ENSP00000420048 C2H2 ZF 161 183
ENSP00000420048 C2H2 ZF 189 211
ENSP00000420048 C2H2 ZF 218 239
ENSP00000420048 C2H2 ZF 734 756
ENSP00000420048 C2H2 ZF 762 785
ENSP00000420048 C2H2 ZF 791 813
ENSP00000420072 C2H2 ZF 21 42
ENSP00000420072 C2H2 ZF 75 97
ENSP00000420466 C2H2 ZF 21 42
ENSP00000420466 C2H2 ZF 75 97
ENSP00000420466 C2H2 ZF 103 125
ENSP00000420466 C2H2 ZF 131 154
ENSP00000420466 C2H2 ZF 160 182
ENSP00000420466 C2H2 ZF 188 210
ENSP00000420466 C2H2 ZF 217 238
ENSP00000420466 C2H2 ZF 724 746
ENSP00000420466 C2H2 ZF 752 775
ENSP00000420466 C2H2 ZF 781 803
ENSP00000486104 C2H2 ZF 21 42
ENSP00000486104 C2H2 ZF 75 97
ENSP00000486104 C2H2 ZF 103 125
ENSP00000486104 C2H2 ZF 131 154
ENSP00000486104 C2H2 ZF 160 182
ENSP00000486104 C2H2 ZF 188 210
ENSP00000486104 C2H2 ZF 217 238
ENSP00000486104 C2H2 ZF 733 755
ENSP00000486104 C2H2 ZF 761 784
ENSP00000486104 C2H2 ZF 790 812

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

53 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSNLEG00000004964 Nomascus leucogenys ENSNLEG00000004964 I 0.827
MECOM Oryctolagus cuniculus ENSOCUG00000010171 I 0.827
ENSMPUG00000017083 Mustela putorius furo ENSMPUG00000017083 I 0.827
MECOM Myotis lucifugus ENSMLUG00000015749 I 0.827
MECOM Loxodonta africana ENSLAFG00000011479 I 0.827
MECOM Otolemur garnettii ENSOGAG00000012812 I 0.827
ENSPPYG00000014277 Pongo abelii ENSPPYG00000014277 I 0.827
Myotis_brandtii_MECOM_10024770 Myotis brandtii Myotis_brandtii_MECOM_10024770 I 0.827
ENSP00000417899-D1 Bos grunniens ENSP00000417899-D1 I 0.827
MECOM Tursiops truncatus ENSTTRG00000002158 I 0.827
MECOM Pan troglodytes ENSPTRG00000015601 I 0.827
MECOM Gorilla gorilla ENSGGOG00000013086 I 0.827
ENSOARG00000000899 Ovis aries ENSOARG00000000899 I 0.827
MECOM Equus caballus ENSECAG00000020788 I 0.827
MECOM Dasypus novemcinctus ENSDNOG00000007746 I 0.827
MECOM Canis familiaris ENSCAFG00000014621 I 0.827
MECOM Callithrix jacchus ENSCJAG00000002651 I 0.827
ENSAMEG00000002052 Ailuropoda melanoleuca ENSAMEG00000002052 I 0.827
MECOM Bos taurus ENSBTAG00000005871 I 0.827
MECOM Felis catus ENSFCAG00000012665 I 0.827
Brh_R009954 Buceros rhinoceros Brh_R009954 I 0.823
ENSGALG00000009437 Gallus gallus ENSGALG00000009437 I 0.823
ENSSHAG00000017530 Sarcophilus harrisii ENSSHAG00000017530 I 0.823
Aan_R014069 Calypte anna Aan_R014069 I 0.823
ENSTGUG00000011015 Taeniopygia guttata ENSTGUG00000011015 I 0.823
Afo_R003945 Aptenodytes forsteri Afo_R003945 I 0.823
Gfo_R004540 Geospiza fortis Gfo_R004540 I 0.823
MECOM Cavia porcellus ENSCPOG00000013572 I 0.823
MECOM Meleagris gallopavo ENSMGAG00000010302 I 0.823
ENSFALG00000008636 Ficedula albicollis ENSFALG00000008636 I 0.823
Tal_R005471 Tyto alba Tal_R005471 I 0.823
ENSAPLG00000012134 Anas platyrhynchos ENSAPLG00000012134 I 0.823
Mecom Rattus norvegicus ENSRNOG00000012645 I 0.822
Mecom Mus musculus ENSMUSG00000027684 D 0.822
MECOM Anolis carolinensis ENSACAG00000015620 I 0.817
Pvit_19180 Pogona vitticeps Pvit_19180 I 0.817
MECOM Monodelphis domestica ENSMODG00000016133 I 0.816
MECOM Macaca mulatta ENSMMUG00000002242 I 0.805
ENSPANG00000001637 Papio anubis ENSPANG00000001637 I 0.805
ENSMMUP00000002995 Macaca fascicularis ENSMMUP00000002995 I 0.805
ENSCSAG00000012539 Chlorocebus sabaeus ENSCSAG00000012539 I 0.804
MECOM Ornithorhynchus anatinus ENSOANG00000007585 I 0.800
Cmyd_10009299 Chelonia mydas Cmyd_10009299 I 0.800
ENSPSIG00000004908 Pelodiscus sinensis ENSPSIG00000004908 I 0.794
ENSLACG00000017233 Latimeria chalumnae ENSLACG00000017233 I 0.792
B7ZRU9 Xenopus laevis B7ZRU9 I 0.784
mecom.L Xenopus laevis XB-GENE-980198 I 0.784
ENSLOCG00000009557 Lepisosteus oculatus ENSLOCG00000009557 I 0.777
mecom.S Xenopus laevis XB-GENE-6448217 I 0.767
B7ZRM8 Xenopus laevis B7ZRM8 I 0.767
ENSXMAG00000010745 Xiphophorus maculatus ENSXMAG00000010745 I 0.763
ENSPFOG00000011975 Poecilia formosa ENSPFOG00000011975 I 0.763