|
MECOM
(Homo sapiens)
C2H2 ZF
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
PF00096 (zf-C2H2) |
IPR007087 |
ENSG00000085276 |
T094812_2.00 |
Ensembl (2018-Dec-8) |
Link out |
NCBI Gene Info:The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
MECOM M08862_2.00 |
Homo sapiens |
HNTNTTATCTTRTCWN |
NWGAYAAGATAANAND |
Misc
Kulakovskiy et al.(2013)
EVI1_HUMAN.H11MO.0.B |
(Direct) |
(Direct) |
MECOM M10125_2.00 |
Homo sapiens |
TTATCTTATCTTRTCW |
WGAYAAGATAAGATAA |
Transfac
Matys et al.(2006)
V$EVI1_01 |
(Direct) |
(Direct) |
MECOM M10126_2.00 |
Homo sapiens |
TTATCTTRTCH |
DGAYAAGATAA |
Transfac
Matys et al.(2006)
V$EVI1_02 |
(Direct) |
(Direct) |
MECOM M10127_2.00 |
Homo sapiens |
TTATCTTATCT |
AGATAAGATAA |
Transfac
Matys et al.(2006)
V$EVI1_03 |
(Direct) |
(Direct) |
MECOM M10128_2.00 |
Homo sapiens |
TAWYYWDWYHTATYH |
DRATADRAHWRRAWA |
Transfac
Matys et al.(2006)
V$EVI1_04 |
(Direct) |
(Direct) |
MECOM M10129_2.00 |
Homo sapiens |
HTATCTTATCT |
AGATAAGATAD |
Transfac
Matys et al.(2006)
V$EVI1_05 |
(Direct) |
(Direct) |
MECOM M10130_2.00 |
Homo sapiens |
TTATCTTGT |
ACAAGATAA |
Transfac
Matys et al.(2006)
V$EVI1_06 |
(Direct) |
(Direct) |
MECOM M10131_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$EVI1_Q3 |
(Direct) |
(Direct) |
MECOM M10132_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$EVI_Q6 |
(Direct) |
(Direct) |
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Mecom
M02667_2.00 |
Mus musculus |
KNTTATCTTRTCTH |
DAGAYAAGATAANM |
SELEX
Mathelier et al.(2014)
MA0029.1
|
0.822
|
0.978
|
Mecom
M08980_2.00 |
Mus musculus |
HNTNTTATCTTRTCWN |
NWGAYAAGATAANAND |
Misc
Kulakovskiy et al.(2013)
EVI1_MOUSE.H11MO.0.B
|
0.822
|
0.978
|
For this family, TFs with SR scores > 0.755 will likely have a similar motif |