PATZ1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000100105 T094822_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PATZ1
M08287_2.00		 Homo sapiens
CCCCDCCC
GGGHGGGG		 ChIP-seq
Schmitges et al.(2016)
Q9HBE1.MEME		 (Direct) (Direct)
PATZ1
M08864_2.00		 Homo sapiens
NYBCHNBYBCMKYCYCYBCCMY
RKGGVRGRGRMKGVRVNDGVRN		 Misc
Kulakovskiy et al.(2013)
PATZ1_HUMAN.H11MO.0.C		 (Direct) (Direct)
PATZ1
M10137_2.00		 Homo sapiens
NDDCCCCCCCCSH
DSGGGGGGGGHHN		 Transfac
Matys et al.(2006)
V$MAZR_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000215919 C2H2 ZF 292 314
ENSP00000215919 C2H2 ZF 356 377
ENSP00000215919 C2H2 ZF 383 405
ENSP00000215919 C2H2 ZF 413 436
ENSP00000266269 C2H2 ZF 292 314
ENSP00000266269 C2H2 ZF 356 377
ENSP00000266269 C2H2 ZF 383 405
ENSP00000266269 C2H2 ZF 413 436
ENSP00000266269 C2H2 ZF 442 464
ENSP00000266269 C2H2 ZF 496 518
ENSP00000337520 C2H2 ZF 292 314
ENSP00000337520 C2H2 ZF 356 377
ENSP00000337520 C2H2 ZF 383 405
ENSP00000337520 C2H2 ZF 413 436
ENSP00000337520 C2H2 ZF 442 464
ENSP00000384173 C2H2 ZF 292 314
ENSP00000384173 C2H2 ZF 356 377
ENSP00000384173 C2H2 ZF 383 405
ENSP00000384173 C2H2 ZF 413 436
ENSP00000384173 C2H2 ZF 442 464

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

51 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action