PATZ1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000100105 T094822_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PATZ1
M08287_2.00
Homo sapiens
CCCCDCCC

GGGHGGGG
ChIP-seq
Schmitges et al.(2016)
Q9HBE1.MEME
(Direct) (Direct)
PATZ1
M08864_2.00
Homo sapiens
NYBCHNBYBCMKYCYCYBCCMY

RKGGVRGRGRMKGVRVNDGVRN
Misc
Kulakovskiy et al.(2013)
PATZ1_HUMAN.H11MO.0.C
(Direct) (Direct)
PATZ1
M10137_2.00
Homo sapiens
NDDCCCCCCCCSH

DSGGGGGGGGHHN
Transfac
Matys et al.(2006)
V$MAZR_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000215919 C2H2 ZF 292 314
ENSP00000215919 C2H2 ZF 356 377
ENSP00000215919 C2H2 ZF 383 405
ENSP00000215919 C2H2 ZF 413 436
ENSP00000266269 C2H2 ZF 292 314
ENSP00000266269 C2H2 ZF 356 377
ENSP00000266269 C2H2 ZF 383 405
ENSP00000266269 C2H2 ZF 413 436
ENSP00000266269 C2H2 ZF 442 464
ENSP00000266269 C2H2 ZF 496 518
ENSP00000337520 C2H2 ZF 292 314
ENSP00000337520 C2H2 ZF 356 377
ENSP00000337520 C2H2 ZF 383 405
ENSP00000337520 C2H2 ZF 413 436
ENSP00000337520 C2H2 ZF 442 464
ENSP00000384173 C2H2 ZF 292 314
ENSP00000384173 C2H2 ZF 356 377
ENSP00000384173 C2H2 ZF 383 405
ENSP00000384173 C2H2 ZF 413 436
ENSP00000384173 C2H2 ZF 442 464

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

51 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PATZ1 Pteropus vampyrus ENSPVAG00000001749 I 0.827
PATZ1 Pan troglodytes ENSPTRG00000014268 I 0.827
ENSPSIG00000011562 Pelodiscus sinensis ENSPSIG00000011562 I 0.827
ENSPPYG00000011732 Pongo abelii ENSPPYG00000011732 I 0.827
PATZ1 Otolemur garnettii ENSOGAG00000027905 I 0.827
ENSPSIG00000016553 Pelodiscus sinensis ENSPSIG00000016553 I 0.825
PATZ1 Ornithorhynchus anatinus ENSOANG00000014654 I 0.827
ENSNLEG00000004385 Nomascus leucogenys ENSNLEG00000004385 I 0.827
Tal_R008892 Tyto alba Tal_R008892 I 0.825
ENSSTOG00000020707 Ictidomys tridecemlineatus ENSSTOG00000020707 I 0.827
PATZ1 Tursiops truncatus ENSTTRG00000010279 I 0.827
Pvit_03702 Pogona vitticeps Pvit_03702 I 0.825
Myotis_brandtii_PATZ1_10027570 Myotis brandtii Myotis_brandtii_PATZ1_10027570 I 0.827
Gfo_R010882 Geospiza fortis Gfo_R010882 I 0.825
ENSP00000266269 Macaca fascicularis ENSP00000266269 I 0.827
ENSP00000266269-D1 Bos grunniens ENSP00000266269-D1 I 0.827
Brh_R010628 Buceros rhinoceros Brh_R010628 I 0.825
Afo_R009044 Aptenodytes forsteri Afo_R009044 I 0.825
Aan_R008287 Calypte anna Aan_R008287 I 0.825
Patz1 Mus musculus ENSMUSG00000020453 I 0.827
ENSAMEG00000007074 Ailuropoda melanoleuca ENSAMEG00000007074 I 0.827
ENSFALG00000007450 Ficedula albicollis ENSFALG00000007450 I 0.825
PATZ1 Gallus gallus ENSGALG00000006934 I 0.824
PATZ1 Cavia porcellus ENSCPOG00000010787 I 0.827
PATZ1 Canis familiaris ENSCAFG00000013087 I 0.827
PATZ1 Gorilla gorilla ENSGGOG00000017171 I 0.827
PATZ1 Bos taurus ENSBTAG00000005478 I 0.827
ENSLACG00000016839 Latimeria chalumnae ENSLACG00000016839 I 0.792
PATZ1 Loxodonta africana ENSLAFG00000002317 I 0.804
PATZ1 Dasypus novemcinctus ENSDNOG00000003183 I 0.827
PATZ1 Macaca mulatta ENSMMUG00000013911 I 0.827
PATZ1 Myotis lucifugus ENSMLUG00000009942 I 0.827
PATZ1 Microcebus murinus ENSMICG00000005430 I 0.827
PATZ1 Meleagris gallopavo ENSMGAG00000008439 I 0.824
ENSAPLG00000003934 Anas platyrhynchos ENSAPLG00000003934 I 0.825
ENSMEUG00000016293 Macropus eugenii ENSMEUG00000016293 I 0.789
PATZ1 Callithrix jacchus ENSCJAG00000010978 N 0.827
Cmyd_10005165 Chelonia mydas Cmyd_10005165 N 0.827
Alligator_sinensis_CCG014139.1 Alligator sinensis Alligator_sinensis_CCG014139.1 N 0.827
Ogr03452 Ophisaurus gracilis Ogr03452 N 0.827
PATZ1 Equus caballus ENSECAG00000025030 N 0.827
PATZ1 Oryctolagus cuniculus ENSOCUG00000002323 N 0.825
PATZ1 Ochotona princeps ENSOPRG00000002286 N 0.825
ENSOARG00000010061 Ovis aries ENSOARG00000010061 N 0.818
ENSCSAG00000008746 Chlorocebus sabaeus ENSCSAG00000008746 N 0.827
Patz1 Rattus norvegicus ENSRNOG00000018709 N 0.827
PATZ1 Sus scrofa ENSSSCG00000010027 N 0.827
PATZ1 Felis catus ENSFCAG00000030253 N 0.827
PATZ1 Taeniopygia guttata ENSTGUG00000009749 N 0.827
ENSMPUG00000012814 Mustela putorius furo ENSMPUG00000012814 N 0.827