GLIS3 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000107249 T094847_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GLIS3
M02880_2.00		 Homo sapiens
CTTYGTGGGGGGTM
KACCCCCCACRAAG		 SELEX
Jolma et al.(2013)
GLIS3_1		 (Direct) (Direct)
GLIS3
M10169_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_01		 (Direct) (Direct)
GLIS3
M10170_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_Q6_01		 (Direct) (Direct)
GLIS3
M10171_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZNF515_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000325494 C2H2 ZF 345 370
ENSP00000325494 C2H2 ZF 379 406
ENSP00000325494 C2H2 ZF 413 436
ENSP00000325494 C2H2 ZF 442 466
ENSP00000325494 C2H2 ZF 472 496
ENSP00000371398 C2H2 ZF 500 525
ENSP00000371398 C2H2 ZF 534 561
ENSP00000371398 C2H2 ZF 568 591
ENSP00000371398 C2H2 ZF 597 621
ENSP00000371398 C2H2 ZF 627 651

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

81 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action