BCL6 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000113916 T094856_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL6
M00227_2.00
Homo sapiens
NTAATTRWNN

NNWYAATTAN
PBM
Barrera et al.(2016)
BCL6_H676Y
(Direct) (Direct)
BCL6
M00228_2.00
Homo sapiens
NNVNDVRANN

NNTYBHNBNN
PBM
Barrera et al.(2016)
BCL6_REF
(Direct) (Direct)
BCL6
M04424_2.00
Homo sapiens
NYGCTTTCKAGGAAHN

NDTTCCTMGAAAGCRN
SELEX
Yin et al.(2017)
BCL6_eDBD_HT-SELEX_1
(Direct) (Direct)
BCL6
M04425_2.00
Homo sapiens
NDTTCCTMGAWWRCVN

NBGYWWTCKAGGAAHN
SELEX
Yin et al.(2017)
BCL6_eDBD_HT-SELEX_2
(Direct) (Direct)
BCL6
M04426_2.00
Homo sapiens
NTGCTTTCTAGGAAHN

NDTTCCTAGAAAGCAN
SELEX
Yin et al.(2017)
BCL6_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
BCL6
M04427_2.00
Homo sapiens
NDTTCCTMGAWWRCVN

NBGYWWTCKAGGAAHN
SELEX
Yin et al.(2017)
BCL6_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
BCL6
M08877_2.00
Homo sapiens
NNMYYTCYAGGAA

TTCCTRGARRKNN
Misc
Kulakovskiy et al.(2013)
BCL6_HUMAN.H11MO.0.A
(Direct) (Direct)
BCL6
M10180_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL6_01
(Direct) (Direct)
BCL6
M10181_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL6_02
(Direct) (Direct)
BCL6
M10182_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL6_Q3_01
(Direct) (Direct)
BCL6
M10183_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL6_Q3
(Direct) (Direct)
BCL6
M10184_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL6_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Bcl6
M08097_2.00
Mus musculus
NDCYYTCYAGGAAN

NTTCCTRGARRGHN
ChIP-seq
Mathelier et al.(2014)
MA0463.1
0.827 1.000
Bcl6
M08024_2.00
Mus musculus
HYNBHHWBWSHTCHYNYYYYYYNBYYHYYH

DRRDRRVNRRRRRRNRDGADSWVWDDVNRD
ChIP-seq
Chen et al.(2011)
SRP001843_Bcl6_IgG_LPSstim
0.827 1.000
Bcl6
M08972_2.00
Mus musculus
NNMTYTCYAGGAA

TTCCTRGARAKNN
Misc
Kulakovskiy et al.(2013)
BCL6_MOUSE.H11MO.0.A
0.827 1.000
Bcl6
M09513_2.00
Mus musculus
NNNNYTTCYWGGAAN

NTTCCWRGAARNNNN
Misc
Heinz et al.(2010)
Liver-Bcl6_GSE31578
0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00227_2.00 C2H2 ZF 15 38
M00227_2.00 C2H2 ZF 43 65
M00227_2.00 C2H2 ZF 71 93
M00227_2.00 C2H2 ZF 99 121
M00227_2.00 C2H2 ZF 127 149
M00227_2.00 C2H2 ZF 155 172
M00228_2.00 C2H2 ZF 15 38
M00228_2.00 C2H2 ZF 43 65
M00228_2.00 C2H2 ZF 71 93
M00228_2.00 C2H2 ZF 99 121
M00228_2.00 C2H2 ZF 127 149
M00228_2.00 C2H2 ZF 155 178

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000232014 C2H2 ZF 518 541
ENSP00000232014 C2H2 ZF 546 568
ENSP00000232014 C2H2 ZF 574 596
ENSP00000232014 C2H2 ZF 602 624
ENSP00000232014 C2H2 ZF 630 652
ENSP00000232014 C2H2 ZF 658 681
ENSP00000384371 C2H2 ZF 518 541
ENSP00000384371 C2H2 ZF 546 568
ENSP00000384371 C2H2 ZF 574 596
ENSP00000384371 C2H2 ZF 602 624
ENSP00000384371 C2H2 ZF 630 652
ENSP00000384371 C2H2 ZF 658 681
ENSP00000413122 C2H2 ZF 518 540
ENSP00000413122 C2H2 ZF 546 568
ENSP00000413122 C2H2 ZF 574 596
ENSP00000413122 C2H2 ZF 602 625
ENSP00000479784 C2H2 ZF 518 540
ENSP00000479784 C2H2 ZF 546 568
ENSP00000479784 C2H2 ZF 574 596
ENSP00000479784 C2H2 ZF 602 625

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

69 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Bcl6 Mus musculus ENSMUSG00000022508 D 0.827
bcl6 Xenopus tropicalis XB-GENE-984479 I 0.787
ENSSHAG00000013935 Sarcophilus harrisii ENSSHAG00000013935 I 0.827
Bcl6 Rattus norvegicus ENSRNOG00000001843 I 0.827
BCL6 Pan troglodytes ENSPTRG00000015728 I 0.827
ENSPSIG00000014529 Pelodiscus sinensis ENSPSIG00000014529 I 0.825
ENSPPYG00000014395 Pongo abelii ENSPPYG00000014395 I 0.827
ENSPANG00000017677 Papio anubis ENSPANG00000017677 I 0.827
BCL6 Ochotona princeps ENSOPRG00000005797 I 0.827
BCL6 Otolemur garnettii ENSOGAG00000007638 I 0.827
BCL6 Oryctolagus cuniculus ENSOCUG00000005429 I 0.827
BCL6 Ornithorhynchus anatinus ENSOANG00000000872 I 0.827
ENSNLEG00000006705 Nomascus leucogenys ENSNLEG00000006705 I 0.827
BCL6 Loxodonta africana ENSLAFG00000012300 I 0.827
BCL6 Sus scrofa ENSSSCG00000011810 I 0.827
BCL6 Taeniopygia guttata ENSTGUG00000009413 I 0.827
bcl6.S Xenopus laevis XB-GENE-17336238 I 0.785
Tal_R005794 Tyto alba Tal_R005794 I 0.827
Pvit_01837 Pogona vitticeps Pvit_01837 I 0.789
Myotis_brandtii_BCL6_10016106 Myotis brandtii Myotis_brandtii_BCL6_10016106 I 0.827
Gfo_R004424 Geospiza fortis Gfo_R004424 I 0.821
ENSP00000384371 Macaca fascicularis ENSP00000384371 I 0.827
ENSBTAP00000001978-D1 Bos grunniens ENSBTAP00000001978-D1 I 0.827
Cmyd_10010560 Chelonia mydas Cmyd_10010560 I 0.825
Brh_R006050 Buceros rhinoceros Brh_R006050 I 0.827
Alligator_sinensis_CCG010229.1 Alligator sinensis Alligator_sinensis_CCG010229.1 I 0.827
Afo_R010236 Aptenodytes forsteri Afo_R010236 I 0.827
Aan_R013387 Calypte anna Aan_R013387 I 0.827
BCL6 Tursiops truncatus ENSTTRG00000017230 I 0.827
bcl6.L Xenopus laevis XB-GENE-984483 I 0.787
ENSMPUG00000003415 Mustela putorius furo ENSMPUG00000003415 I 0.827
BCL6 Macaca mulatta ENSMMUG00000009198 I 0.827
BCL6 Myotis lucifugus ENSMLUG00000012905 I 0.827
ENSFALG00000007407 Ficedula albicollis ENSFALG00000007407 I 0.827
BCL6 Echinops telfairi ENSETEG00000014830 I 0.817
BCL6 Erinaceus europaeus ENSEEUG00000000344 I 0.827
BCL6 Equus caballus ENSECAG00000004556 I 0.827
Bcl6 Dipodomys ordii ENSDORG00000005608 I 0.827
BCL6 Bos taurus ENSBTAG00000001511 I 0.827
BCL6 Dasypus novemcinctus ENSDNOG00000004306 I 0.819
BCL6 Canis familiaris ENSCAFG00000013904 I 0.827
BCL6 Callithrix jacchus ENSCJAG00000014375 I 0.827
ENSCSAG00000009138 Chlorocebus sabaeus ENSCSAG00000009138 I 0.827
BCL6 Felis catus ENSFCAG00000006810 I 0.827
ENSAPLG00000015868 Anas platyrhynchos ENSAPLG00000015868 I 0.798
BCL6 Microcebus murinus ENSMICG00000001780 I 0.827
BCL6 Meleagris gallopavo ENSMGAG00000007602 I 0.827
ENSMEUG00000004411 Macropus eugenii ENSMEUG00000004411 I 0.827
BCL6 Anolis carolinensis ENSACAG00000006666 I 0.787
ENSAMEG00000000812 Ailuropoda melanoleuca ENSAMEG00000000812 I 0.827
BCL6 Gorilla gorilla ENSGGOG00000026549 I 0.827
BCL6 Gallus gallus ENSGALG00000007357 I 0.827
BCL6 Cavia porcellus ENSCPOG00000004090 I 0.827
SNAPOd2T00000666001 Oikopleura dioica SNAPOd2T00000666001 N 0.785
ENSAMXG00000012978 Astyanax mexicanus ENSAMXG00000012978 N 0.792
ENSCING00000007627 Ciona intestinalis ENSCING00000007627 N 0.771
ENSAMXG00000018736 Astyanax mexicanus ENSAMXG00000018736 N 0.806
ENSCSAVG00000006275 Ciona savignyi ENSCSAVG00000006275 N 0.774
ENSLOCG00000013298 Lepisosteus oculatus ENSLOCG00000013298 N 0.792
ENSGMOG00000013899 Gadus morhua ENSGMOG00000013899 N 0.789
ENSONIG00000004819 Oreochromis niloticus ENSONIG00000004819 N 0.792
bcl6b Oryzias latipes ENSORLG00000006659 N 0.780
ENSPFOG00000009503 Poecilia formosa ENSPFOG00000009503 N 0.792
bcl6b Gasterosteus aculeatus ENSGACG00000019349 N 0.792
bcl6b Tetraodon nigroviridis ENSTNIG00000002560 N 0.792
bcl6b Danio rerio ENSDARG00000069335 N 0.795
bcl6ab Danio rerio ENSDARG00000069295 N 0.818
bcl6b Takifugu rubripes ENSTRUG00000013220 N 0.792