CTCFL (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000124092 T094884_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CTCFL
M07930_2.00
Homo sapiens
RGCGCCCCCTRSNGG

CCNSYAGGGGGCGCY
ChIP-seq
Gerstein et al.(2012)
K562_CTCFL_HudsonAlpha
(Direct) (Direct)
CTCFL
M08089_2.00
Homo sapiens
NSYGCCCCCTGSNG

CNSCAGGGGGCRSN
ChIP-seq
Mathelier et al.(2014)
MA1102.1
(Direct) (Direct)
CTCFL
M08885_2.00
Homo sapiens
BRSCGCCCCCTDSHGGN

NCCDSHAGGGGGCGSYV
Misc
Kulakovskiy et al.(2013)
CTCFL_HUMAN.H11MO.0.A
(Direct) (Direct)
CTCFL
M09507_2.00
Homo sapiens
NNNBDSYGCCMYCTDSHGGN

NCCDSHAGRKGGCRSHVNNN
Misc
Heinz et al.(2010)
K562-CTCFL_GSE32465
(Direct) (Direct)
CTCFL
M10200_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CTCFL_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000243914 C2H2 ZF 257 279
ENSP00000243914 C2H2 ZF 285 307
ENSP00000243914 C2H2 ZF 313 336
ENSP00000243914 C2H2 ZF 342 364
ENSP00000243914 C2H2 ZF 370 392
ENSP00000243914 C2H2 ZF 398 421
ENSP00000243914 C2H2 ZF 428 451
ENSP00000243914 C2H2 ZF 458 480
ENSP00000243914 C2H2 ZF 486 508
ENSP00000243914 C2H2 ZF 514 537
ENSP00000243914 C2H2 ZF 546 567
ENSP00000360239 C2H2 ZF 257 279
ENSP00000360239 C2H2 ZF 285 307
ENSP00000360239 C2H2 ZF 313 336
ENSP00000360239 C2H2 ZF 342 364
ENSP00000360239 C2H2 ZF 370 392
ENSP00000360239 C2H2 ZF 398 421
ENSP00000360239 C2H2 ZF 428 451
ENSP00000360239 C2H2 ZF 458 480
ENSP00000360239 C2H2 ZF 486 508
ENSP00000360239 C2H2 ZF 514 537
ENSP00000360239 C2H2 ZF 546 567
ENSP00000392034 C2H2 ZF 52 74
ENSP00000392034 C2H2 ZF 80 102
ENSP00000392034 C2H2 ZF 108 131
ENSP00000392034 C2H2 ZF 137 159
ENSP00000392034 C2H2 ZF 165 187
ENSP00000392034 C2H2 ZF 193 216
ENSP00000392034 C2H2 ZF 223 246
ENSP00000392034 C2H2 ZF 253 275
ENSP00000392034 C2H2 ZF 281 303
ENSP00000392034 C2H2 ZF 309 332
ENSP00000392034 C2H2 ZF 341 362
ENSP00000399061 C2H2 ZF 257 279
ENSP00000399061 C2H2 ZF 285 307
ENSP00000399061 C2H2 ZF 313 336
ENSP00000399061 C2H2 ZF 342 364
ENSP00000399061 C2H2 ZF 370 392
ENSP00000399061 C2H2 ZF 398 421
ENSP00000399061 C2H2 ZF 428 451
ENSP00000399061 C2H2 ZF 458 480
ENSP00000399061 C2H2 ZF 486 508
ENSP00000399061 C2H2 ZF 514 537
ENSP00000399061 C2H2 ZF 546 560
ENSP00000403369 C2H2 ZF 257 279
ENSP00000403369 C2H2 ZF 285 307
ENSP00000403369 C2H2 ZF 313 336
ENSP00000403369 C2H2 ZF 342 364
ENSP00000403369 C2H2 ZF 370 392
ENSP00000403369 C2H2 ZF 398 421
ENSP00000409344 C2H2 ZF 257 279
ENSP00000409344 C2H2 ZF 285 307
ENSP00000409344 C2H2 ZF 313 336
ENSP00000409344 C2H2 ZF 342 364
ENSP00000409344 C2H2 ZF 370 393
ENSP00000409344 C2H2 ZF 402 418
ENSP00000413713 C2H2 ZF 257 279
ENSP00000413713 C2H2 ZF 285 307
ENSP00000413713 C2H2 ZF 313 336
ENSP00000413713 C2H2 ZF 342 364
ENSP00000413713 C2H2 ZF 370 392
ENSP00000415329 C2H2 ZF 257 279
ENSP00000415329 C2H2 ZF 285 307
ENSP00000415329 C2H2 ZF 313 336
ENSP00000415329 C2H2 ZF 342 364
ENSP00000415329 C2H2 ZF 370 392
ENSP00000415329 C2H2 ZF 408 430
ENSP00000415329 C2H2 ZF 436 458
ENSP00000415329 C2H2 ZF 464 487
ENSP00000415329 C2H2 ZF 496 517
ENSP00000415579 C2H2 ZF 257 279
ENSP00000415579 C2H2 ZF 285 307
ENSP00000415579 C2H2 ZF 313 336
ENSP00000415579 C2H2 ZF 342 364
ENSP00000415579 C2H2 ZF 370 392
ENSP00000415579 C2H2 ZF 398 421
ENSP00000415579 C2H2 ZF 428 451
ENSP00000415579 C2H2 ZF 458 480
ENSP00000415579 C2H2 ZF 486 508
ENSP00000415579 C2H2 ZF 514 537
ENSP00000415579 C2H2 ZF 546 567
ENSP00000437999 C2H2 ZF 23 45
ENSP00000437999 C2H2 ZF 51 74
ENSP00000437999 C2H2 ZF 80 102
ENSP00000437999 C2H2 ZF 108 130
ENSP00000437999 C2H2 ZF 136 159
ENSP00000437999 C2H2 ZF 166 189
ENSP00000437999 C2H2 ZF 196 218
ENSP00000437999 C2H2 ZF 224 246
ENSP00000437999 C2H2 ZF 252 275
ENSP00000437999 C2H2 ZF 284 305
ENSP00000439998 C2H2 ZF 52 74
ENSP00000439998 C2H2 ZF 80 102
ENSP00000439998 C2H2 ZF 108 131
ENSP00000439998 C2H2 ZF 137 159
ENSP00000439998 C2H2 ZF 165 187
ENSP00000439998 C2H2 ZF 193 216
ENSP00000439998 C2H2 ZF 223 246
ENSP00000439998 C2H2 ZF 253 275
ENSP00000439998 C2H2 ZF 281 303
ENSP00000439998 C2H2 ZF 309 332
ENSP00000439998 C2H2 ZF 341 357
ENSP00000476398 C2H2 ZF 257 279
ENSP00000476398 C2H2 ZF 285 307
ENSP00000476398 C2H2 ZF 313 336
ENSP00000476398 C2H2 ZF 342 364
ENSP00000476398 C2H2 ZF 370 392
ENSP00000476398 C2H2 ZF 398 421
ENSP00000476398 C2H2 ZF 428 451
ENSP00000476398 C2H2 ZF 458 480
ENSP00000476398 C2H2 ZF 486 508
ENSP00000476398 C2H2 ZF 514 537
ENSP00000476398 C2H2 ZF 546 567
ENSP00000476458 C2H2 ZF 257 279
ENSP00000476458 C2H2 ZF 285 307
ENSP00000476458 C2H2 ZF 313 336
ENSP00000476458 C2H2 ZF 342 364
ENSP00000476458 C2H2 ZF 370 392
ENSP00000476458 C2H2 ZF 398 421
ENSP00000476458 C2H2 ZF 428 451
ENSP00000476458 C2H2 ZF 458 480
ENSP00000476458 C2H2 ZF 486 508
ENSP00000476458 C2H2 ZF 514 537
ENSP00000476458 C2H2 ZF 546 562
ENSP00000476577 C2H2 ZF 257 279
ENSP00000476577 C2H2 ZF 285 307
ENSP00000476577 C2H2 ZF 313 336
ENSP00000476718 C2H2 ZF 2 17
ENSP00000476718 C2H2 ZF 23 45
ENSP00000476718 C2H2 ZF 51 74
ENSP00000476718 C2H2 ZF 80 102
ENSP00000476718 C2H2 ZF 108 130
ENSP00000476718 C2H2 ZF 136 159
ENSP00000476718 C2H2 ZF 166 189
ENSP00000476718 C2H2 ZF 196 218
ENSP00000476718 C2H2 ZF 224 246
ENSP00000476718 C2H2 ZF 252 275
ENSP00000476718 C2H2 ZF 284 299
ENSP00000476783 C2H2 ZF 257 279
ENSP00000476783 C2H2 ZF 285 307
ENSP00000476783 C2H2 ZF 313 336
ENSP00000476783 C2H2 ZF 342 364
ENSP00000476783 C2H2 ZF 370 392
ENSP00000476783 C2H2 ZF 398 421
ENSP00000476783 C2H2 ZF 428 451
ENSP00000476783 C2H2 ZF 458 480
ENSP00000476783 C2H2 ZF 486 508
ENSP00000476783 C2H2 ZF 514 537
ENSP00000476783 C2H2 ZF 546 567
ENSP00000477165 C2H2 ZF 257 279
ENSP00000477165 C2H2 ZF 285 307
ENSP00000477165 C2H2 ZF 313 336
ENSP00000477412 C2H2 ZF 257 279
ENSP00000477412 C2H2 ZF 285 307
ENSP00000477412 C2H2 ZF 313 336
ENSP00000477412 C2H2 ZF 342 364
ENSP00000477412 C2H2 ZF 370 392
ENSP00000477488 C2H2 ZF 257 279
ENSP00000477488 C2H2 ZF 285 307
ENSP00000477488 C2H2 ZF 313 336
ENSP00000477488 C2H2 ZF 342 364
ENSP00000477488 C2H2 ZF 370 392
ENSP00000477488 C2H2 ZF 398 421
ENSP00000477488 C2H2 ZF 428 451
ENSP00000477488 C2H2 ZF 458 480
ENSP00000477488 C2H2 ZF 486 508
ENSP00000477488 C2H2 ZF 514 537
ENSP00000477488 C2H2 ZF 546 567

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

8 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
CTCFL Gorilla gorilla ENSGGOG00000005761 I 0.805
CTCFL Macaca mulatta ENSMMUG00000016802 I 0.792
CTCFL Pan troglodytes ENSPTRG00000013663 I 0.827
ENSMMUP00000022088 Macaca fascicularis ENSMMUP00000022088 I 0.793
ENSMPUG00000006570 Mustela putorius furo ENSMPUG00000006570 N 0.784
ENSNLEG00000007062 Nomascus leucogenys ENSNLEG00000007062 I 0.779
ENSPPYG00000011163 Pongo abelii ENSPPYG00000011163 I 0.806