RREB1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000124782 T094891_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RREB1
M02665_2.00		 Homo sapiens
MCMCMAMMCAMCMMCHMMSV
BSKKDGKKGKTGKKTKGKGK		 SELEX
Mathelier et al.(2014)
MA0073.1		 (Direct) (Direct)
RREB1
M10203_2.00		 Homo sapiens
MCCCAAMCMMMCMM
KKGKKKGKTTGGGK		 Transfac
Matys et al.(2006)
V$RREB1_01		 (Direct) (Direct)
RREB1
M10204_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RREB1_Q5		 (Direct) (Direct)
RREB1
M10205_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$RREB_Q5		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000305560 C2H2 ZF 66 88
ENSP00000305560 C2H2 ZF 97 119
ENSP00000305560 C2H2 ZF 125 147
ENSP00000305560 C2H2 ZF 643 665
ENSP00000305560 C2H2 ZF 671 693
ENSP00000305560 C2H2 ZF 699 722
ENSP00000305560 C2H2 ZF 753 775
ENSP00000305560 C2H2 ZF 790 813
ENSP00000305560 C2H2 ZF 1512 1534
ENSP00000305560 C2H2 ZF 1540 1562
ENSP00000335574 C2H2 ZF 66 88
ENSP00000335574 C2H2 ZF 97 119
ENSP00000335574 C2H2 ZF 125 147
ENSP00000335574 C2H2 ZF 643 665
ENSP00000335574 C2H2 ZF 671 693
ENSP00000335574 C2H2 ZF 699 722
ENSP00000335574 C2H2 ZF 753 775
ENSP00000335574 C2H2 ZF 790 813
ENSP00000335574 C2H2 ZF 1246 1268
ENSP00000335574 C2H2 ZF 1274 1297
ENSP00000335574 C2H2 ZF 1329 1351
ENSP00000369265 C2H2 ZF 66 88
ENSP00000369265 C2H2 ZF 97 119
ENSP00000369265 C2H2 ZF 125 147
ENSP00000369265 C2H2 ZF 643 665
ENSP00000369265 C2H2 ZF 671 693
ENSP00000369265 C2H2 ZF 699 722
ENSP00000369265 C2H2 ZF 753 775
ENSP00000369265 C2H2 ZF 790 813
ENSP00000369265 C2H2 ZF 1512 1534
ENSP00000369265 C2H2 ZF 1540 1562
ENSP00000369270 C2H2 ZF 66 88
ENSP00000369270 C2H2 ZF 97 119
ENSP00000369270 C2H2 ZF 125 147
ENSP00000369270 C2H2 ZF 643 665
ENSP00000369270 C2H2 ZF 671 693
ENSP00000369270 C2H2 ZF 699 722
ENSP00000369270 C2H2 ZF 753 775
ENSP00000369270 C2H2 ZF 790 813
ENSP00000369270 C2H2 ZF 1246 1268
ENSP00000369270 C2H2 ZF 1274 1297
ENSP00000369270 C2H2 ZF 1567 1589
ENSP00000369270 C2H2 ZF 1595 1617
ENSP00000419511 C2H2 ZF 66 88
ENSP00000419511 C2H2 ZF 97 119
ENSP00000419511 C2H2 ZF 125 147
ENSP00000419511 C2H2 ZF 643 665
ENSP00000419511 C2H2 ZF 671 693
ENSP00000419511 C2H2 ZF 699 722
ENSP00000419511 C2H2 ZF 753 775
ENSP00000420299 C2H2 ZF 66 88
ENSP00000420299 C2H2 ZF 97 119
ENSP00000420299 C2H2 ZF 125 147
ENSP00000420519 C2H2 ZF 66 88
ENSP00000420519 C2H2 ZF 97 119
ENSP00000420519 C2H2 ZF 125 136
ENSP00000483108 C2H2 ZF 580 602
ENSP00000483108 C2H2 ZF 608 630

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

44 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
RREB1 Gorilla gorilla ENSGGOG00000004561 I 0.827
RREB1 Otolemur garnettii ENSOGAG00000025755 N 0.827
ENSNLEG00000011554 Nomascus leucogenys ENSNLEG00000011554 I 0.827
RREB1 Sus scrofa ENSSSCG00000001021 N 0.827
RREB1 Pan troglodytes ENSPTRG00000017697 I 0.827
Rreb1 Rattus norvegicus ENSRNOG00000015701 I 0.827
RREB1 Macaca mulatta ENSMMUG00000007852 I 0.827
ENSPPYG00000016204 Pongo abelii ENSPPYG00000016204 I 0.827
ENSPANG00000019553 Papio anubis ENSPANG00000019553 I 0.827
ENSP00000369270 Macaca fascicularis ENSP00000369270 I 0.827
RREB1 Callithrix jacchus ENSCJAG00000021358 N 0.827
ENSCSAG00000007376 Chlorocebus sabaeus ENSCSAG00000007376 I 0.827
ENSAMEG00000017412 Ailuropoda melanoleuca ENSAMEG00000017412 I 0.826
RREB1 Canis familiaris ENSCAFG00000009527 I 0.825
RREB1 Cavia porcellus ENSCPOG00000014380 N 0.823
ENSOANG00000032215 Ornithorhynchus anatinus ENSOANG00000032215 N 0.822
RREB1 Equus caballus ENSECAG00000018169 N 0.821
RREB1 Loxodonta africana ENSLAFG00000005300 I 0.821
RREB1 Myotis lucifugus ENSMLUG00000013153 N 0.820
Myotis_brandtii_RREB1_10008109 Myotis brandtii Myotis_brandtii_RREB1_10008109 N 0.820
Aan_R012638 Calypte anna Aan_R012638 N 0.819
Gfo_R006486 Geospiza fortis Gfo_R006486 N 0.819
Afo_R014721 Aptenodytes forsteri Afo_R014721 N 0.819
RREB1 Taeniopygia guttata ENSTGUG00000002309 N 0.819
Rreb1 Mus musculus ENSMUSG00000039087 I 0.819
RREB1 Meleagris gallopavo ENSMGAG00000003910 N 0.819
RREB1 Gallus gallus ENSGALG00000012799 N 0.819
ENSAPLG00000004726 Anas platyrhynchos ENSAPLG00000004726 N 0.819
ENSPSIG00000006582 Pelodiscus sinensis ENSPSIG00000006582 N 0.818
ENSMPUG00000000558 Mustela putorius furo ENSMPUG00000000558 I 0.818
ENSSHAG00000005295 Sarcophilus harrisii ENSSHAG00000005295 N 0.816
ENSFALG00000013231 Ficedula albicollis ENSFALG00000013231 N 0.814
RREB1 Ochotona princeps ENSOPRG00000001966 N 0.814
ENSMEUG00000015377 Macropus eugenii ENSMEUG00000015377 I 0.813
RREB1 Monodelphis domestica ENSMODG00000009892 I 0.813
RREB1 Felis catus ENSFCAG00000030069 I 0.810
RREB1 Pteropus vampyrus ENSPVAG00000014081 I 0.809
ENSBTAP00000042051-D1 Bos grunniens ENSBTAP00000042051-D1 N 0.805
Cmyd_10003405 Chelonia mydas Cmyd_10003405 I 0.803
rreb1a Danio rerio ENSDARG00000063701 N 0.801
ENSOANG00000030073 Ornithorhynchus anatinus ENSOANG00000030073 N 0.795
RREB1 Anolis carolinensis ENSACAG00000000520 I 0.787
ENSONIG00000013406 Oreochromis niloticus ENSONIG00000013406 N 0.759