ZNF384 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000126746 T094899_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF384
M04451_2.00
Homo sapiens
TTTTBNNNNNNNNNNNNVAAAA

TTTTBNNNNNNNNNNNNVAAAA
SELEX
Yin et al.(2017)
ZNF384_eDBD_HT-SELEX
(Direct) (Direct)
ZNF384
M04452_2.00
Homo sapiens
KTTTYHNNNNNNNNNNDRAAAV

BTTTYHNNNNNNNNNNDRAAAM
SELEX
Yin et al.(2017)
ZNF384_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
ZNF384
M08090_2.00
Homo sapiens
WTTTTTTTNHNN

NNDNAAAAAAAW
ChIP-seq
Mathelier et al.(2014)
MA1125.1
(Direct) (Direct)
ZNF384
M08306_2.00
Homo sapiens
CTTTTTTTT

AAAAAAAAG
ChIP-seq
Schmitges et al.(2016)
Q8TF68_1-3.RCADE
(Direct) (Direct)
ZNF384
M08888_2.00
Homo sapiens
BVNNBTTTTTSC

GSAAAAAVNNBV
Misc
Kulakovskiy et al.(2013)
ZN384_HUMAN.H11MO.0.C
(Direct) (Direct)
ZNF384
M10209_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CIZ_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000321650 C2H2 ZF 228 250
ENSP00000321650 C2H2 ZF 256 278
ENSP00000321650 C2H2 ZF 284 306
ENSP00000321650 C2H2 ZF 312 336
ENSP00000321650 C2H2 ZF 342 364
ENSP00000321650 C2H2 ZF 372 394
ENSP00000348018 C2H2 ZF 173 195
ENSP00000348018 C2H2 ZF 201 223
ENSP00000348018 C2H2 ZF 229 251
ENSP00000348018 C2H2 ZF 257 281
ENSP00000348018 C2H2 ZF 287 309
ENSP00000348018 C2H2 ZF 317 339
ENSP00000354592 C2H2 ZF 228 250
ENSP00000354592 C2H2 ZF 256 278
ENSP00000354592 C2H2 ZF 284 306
ENSP00000354592 C2H2 ZF 317 339
ENSP00000354592 C2H2 ZF 345 367
ENSP00000354592 C2H2 ZF 373 397
ENSP00000354592 C2H2 ZF 403 425
ENSP00000354592 C2H2 ZF 433 455
ENSP00000380019 C2H2 ZF 228 250
ENSP00000380019 C2H2 ZF 256 278
ENSP00000380019 C2H2 ZF 284 306
ENSP00000380019 C2H2 ZF 317 339
ENSP00000380019 C2H2 ZF 345 367
ENSP00000380019 C2H2 ZF 373 397
ENSP00000380019 C2H2 ZF 403 425
ENSP00000380019 C2H2 ZF 433 455
ENSP00000399572 C2H2 ZF 261 281
ENSP00000399572 C2H2 ZF 287 309
ENSP00000399572 C2H2 ZF 315 337
ENSP00000399572 C2H2 ZF 348 370
ENSP00000412911 C2H2 ZF 212 234
ENSP00000412911 C2H2 ZF 240 262
ENSP00000473311 C2H2 ZF 2 24
ENSP00000473311 C2H2 ZF 32 45

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Pvit_12574 Pogona vitticeps Pvit_12574 I 0.771
ZNF384 Pan troglodytes ENSPTRG00000004584 I 0.827
ENSPPYG00000004196 Pongo abelii ENSPPYG00000004196 I 0.827
ENSPFOG00000015360 Poecilia formosa ENSPFOG00000015360 I 0.756
ENSPFOG00000001513 Poecilia formosa ENSPFOG00000001513 I 0.761
ENSPANG00000014845 Papio anubis ENSPANG00000014845 I 0.827
ZNF384 Ochotona princeps ENSOPRG00000003626 I 0.827
ENSONIG00000013041 Oreochromis niloticus ENSONIG00000013041 I 0.756
ZNF384 Otolemur garnettii ENSOGAG00000010052 I 0.827
ZNF384 Oryctolagus cuniculus ENSOCUG00000003747 I 0.827
ZNF384 Pteropus vampyrus ENSPVAG00000011440 I 0.816
Zfp384 Rattus norvegicus ENSRNOG00000017066 I 0.810
ENSSHAG00000015330 Sarcophilus harrisii ENSSHAG00000015330 I 0.814
Ogr12333 Ophisaurus gracilis Ogr12333 I 0.771
Myotis_brandtii_ZNF384_10009390 Myotis brandtii Myotis_brandtii_ZNF384_10009390 I 0.826
ENSP00000380019 Macaca fascicularis ENSP00000380019 I 0.798
ENSBTAP00000022702-D1 Bos grunniens ENSBTAP00000022702-D1 I 0.798
Cmyd_10003951 Chelonia mydas Cmyd_10003951 I 0.807
Alligator_sinensis_CCG002534.1 Alligator sinensis Alligator_sinensis_CCG002534.1 I 0.807
ENSXMAG00000016787 Xiphophorus maculatus ENSXMAG00000016787 I 0.761
ZNF384 Tursiops truncatus ENSTTRG00000011754 I 0.798
ENSSTOG00000009902 Ictidomys tridecemlineatus ENSSTOG00000009902 I 0.827
ZNF384 Sus scrofa ENSSSCG00000000702 I 0.827
ZNF384 Procavia capensis ENSPCAG00000012951 I 0.827
ENSNLEG00000004506 Nomascus leucogenys ENSNLEG00000004506 I 0.827
Zfp384 Mus musculus ENSMUSG00000038346 I 0.810
ZNF384 Erinaceus europaeus ENSEEUG00000012950 I 0.820
ZNF384 Equus caballus ENSECAG00000009490 I 0.798
ZNF384 Dasypus novemcinctus ENSDNOG00000003936 I 0.798
ENSCSAG00000010379 Chlorocebus sabaeus ENSCSAG00000010379 I 0.827
ZNF384 Callithrix jacchus ENSCJAG00000007944 I 0.827
ZNF384 Choloepus hoffmanni ENSCHOG00000006697 I 0.825
ZNF384 Canis familiaris ENSCAFG00000014740 I 0.827
ZNF384 Bos taurus ENSBTAG00000017072 I 0.798
ENSAMXG00000014229 Astyanax mexicanus ENSAMXG00000014229 I 0.756
ENSAMEG00000014121 Ailuropoda melanoleuca ENSAMEG00000014121 I 0.827
ENSFALG00000004741 Ficedula albicollis ENSFALG00000004741 I 0.807
ZNF384 Felis catus ENSFCAG00000006882 I 0.827
ENSMPUG00000016838 Mustela putorius furo ENSMPUG00000016838 I 0.827
ZNF384 Monodelphis domestica ENSMODG00000018105 I 0.804
ZNF384 Macaca mulatta ENSMMUG00000016990 I 0.827
ZNF384 Myotis lucifugus ENSMLUG00000013771 I 0.826
ZNF384 Anolis carolinensis ENSACAG00000006099 I 0.771
ENSLOCG00000007968 Lepisosteus oculatus ENSLOCG00000007968 I 0.759
ZNF384 Loxodonta africana ENSLAFG00000008381 I 0.827
ZNF384 Gorilla gorilla ENSGGOG00000016048 I 0.827
ENSOARG00000007041 Ovis aries ENSOARG00000007041 N 0.779
ZNF384 Cavia porcellus ENSCPOG00000012313 N 0.796
Ogr07132 Ophisaurus gracilis Ogr07132 N 0.763
ENSGALG00000014459 Gallus gallus ENSGALG00000014459 N 0.810
ZNF384 Meleagris gallopavo ENSMGAG00000014101 N 0.810