ZNF384 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000126746 T094899_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF384
M04451_2.00
Homo sapiens
TTTTBNNNNNNNNNNNNVAAAA

TTTTBNNNNNNNNNNNNVAAAA
SELEX
Yin et al.(2017)
ZNF384_eDBD_HT-SELEX
(Direct) (Direct)
ZNF384
M04452_2.00
Homo sapiens
KTTTYHNNNNNNNNNNDRAAAV

BTTTYHNNNNNNNNNNDRAAAM
SELEX
Yin et al.(2017)
ZNF384_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
ZNF384
M08090_2.00
Homo sapiens
WTTTTTTTNHNN

NNDNAAAAAAAW
ChIP-seq
Mathelier et al.(2014)
MA1125.1
(Direct) (Direct)
ZNF384
M08306_2.00
Homo sapiens
CTTTTTTTT

AAAAAAAAG
ChIP-seq
Schmitges et al.(2016)
Q8TF68_1-3.RCADE
(Direct) (Direct)
ZNF384
M08888_2.00
Homo sapiens
BVNNBTTTTTSC

GSAAAAAVNNBV
Misc
Kulakovskiy et al.(2013)
ZN384_HUMAN.H11MO.0.C
(Direct) (Direct)
ZNF384
M10209_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CIZ_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000321650 C2H2 ZF 228 250
ENSP00000321650 C2H2 ZF 256 278
ENSP00000321650 C2H2 ZF 284 306
ENSP00000321650 C2H2 ZF 312 336
ENSP00000321650 C2H2 ZF 342 364
ENSP00000321650 C2H2 ZF 372 394
ENSP00000348018 C2H2 ZF 173 195
ENSP00000348018 C2H2 ZF 201 223
ENSP00000348018 C2H2 ZF 229 251
ENSP00000348018 C2H2 ZF 257 281
ENSP00000348018 C2H2 ZF 287 309
ENSP00000348018 C2H2 ZF 317 339
ENSP00000354592 C2H2 ZF 228 250
ENSP00000354592 C2H2 ZF 256 278
ENSP00000354592 C2H2 ZF 284 306
ENSP00000354592 C2H2 ZF 317 339
ENSP00000354592 C2H2 ZF 345 367
ENSP00000354592 C2H2 ZF 373 397
ENSP00000354592 C2H2 ZF 403 425
ENSP00000354592 C2H2 ZF 433 455
ENSP00000380019 C2H2 ZF 228 250
ENSP00000380019 C2H2 ZF 256 278
ENSP00000380019 C2H2 ZF 284 306
ENSP00000380019 C2H2 ZF 317 339
ENSP00000380019 C2H2 ZF 345 367
ENSP00000380019 C2H2 ZF 373 397
ENSP00000380019 C2H2 ZF 403 425
ENSP00000380019 C2H2 ZF 433 455
ENSP00000399572 C2H2 ZF 261 281
ENSP00000399572 C2H2 ZF 287 309
ENSP00000399572 C2H2 ZF 315 337
ENSP00000399572 C2H2 ZF 348 370
ENSP00000412911 C2H2 ZF 212 234
ENSP00000412911 C2H2 ZF 240 262
ENSP00000473311 C2H2 ZF 2 24
ENSP00000473311 C2H2 ZF 32 45

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSECAG00000002506 Equus caballus ENSECAG00000002506 I 0.000
Brh_R000011 Buceros rhinoceros Brh_R000011 I 0.000
SCUD_0000383301 Schistosoma curassoni SCUD_0000383301 N 0.000
ANCDUO_19178 Ancylostoma duodenale ANCDUO_19178 N 0.000
LDEC024564 Leptinotarsa decemlineata LDEC024564 N 0.000
Ocbimv22024374m.g Octopus bimaculoides Ocbimv22024374m.g N 0.000
Gfo_R000008 Geospiza fortis Gfo_R000008 N 0.000
Ca_23643 Cicer arietinum Ca_23643 N 0.000
ORUFI09G21220 Oryza rufipogon ORUFI09G21220 N 0.000
ISCW012461 Ixodes scapularis ISCW012461 N 0.000
GRMZM2G381748 Zea mays GRMZM2G381748 N 0.000
snap_masked-nMf.1.1.scaf13062-processed-gene-0.2 Meloidogyne floridensis snap_masked-nMf.1.1.scaf13062-processed-gene-0.2 N 0.000