BCL11B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000127152 T094903_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11B
M00986_2.00
Homo sapiens
BTHYGGMCV

BGKCCRDAV
PBM
Liu et al.(2018)
BCL11B_23
(Direct) (Direct)
BCL11B
M00987_2.00
Homo sapiens
NNNTGWCCVN

NBGGWCANNN
PBM
Liu et al.(2018)
BCL11B_456
(Direct) (Direct)
BCL11B
M00988_2.00
Homo sapiens
NNTGWCCVN

NBGGWCANN
PBM
Liu et al.(2018)
BCL11B_XL
(Direct) (Direct)
BCL11B
M04453_2.00
Homo sapiens
GTGAACGBNDNNVCTACAC

GTGTAGBNNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_HT-SELEX
(Direct) (Direct)
BCL11B
M04454_2.00
Homo sapiens
GTGAACGBNDNHVCTACAC

GTGTAGBDNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11A
M07926_2.00
Homo sapiens
BTYTCASTTCCYYHH

DDRRGGAASTGARAV
ChIP-seq
Gerstein et al.(2012)
GM12878_BCL11A_HudsonAlpha
0.806 0.947
BCL11A
M08881_2.00
Homo sapiens
BHBYCABTTCCYBHNYN

NRNDVRGGAAVTGRVDV
Misc
Kulakovskiy et al.(2013)
BC11A_HUMAN.H11MO.0.A
0.806 0.947
BCL11A
M10187_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL11A_02
0.806 0.947
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00986_2.00 C2H2 ZF 16 38
M00986_2.00 C2H2 ZF 44 68
M00987_2.00 C2H2 ZF 16 38
M00987_2.00 C2H2 ZF 44 66
M00987_2.00 C2H2 ZF 74 97
M00988_2.00 C2H2 ZF 149 172
M00988_2.00 C2H2 ZF 355 376
M00988_2.00 C2H2 ZF 382 404
M00988_2.00 C2H2 ZF 714 736
M00988_2.00 C2H2 ZF 742 764
M00988_2.00 C2H2 ZF 772 795

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000280435 C2H2 ZF 357 378
ENSP00000280435 C2H2 ZF 384 406
ENSP00000280435 C2H2 ZF 725 747
ENSP00000280435 C2H2 ZF 753 775
ENSP00000280435 C2H2 ZF 783 806
ENSP00000349723 C2H2 ZF 149 172
ENSP00000349723 C2H2 ZF 355 376
ENSP00000349723 C2H2 ZF 382 404
ENSP00000349723 C2H2 ZF 714 736
ENSP00000349723 C2H2 ZF 742 764
ENSP00000349723 C2H2 ZF 772 795
ENSP00000387419 C2H2 ZF 235 257
ENSP00000387419 C2H2 ZF 263 287
ENSP00000387419 C2H2 ZF 602 624
ENSP00000387419 C2H2 ZF 630 652
ENSP00000387419 C2H2 ZF 660 683

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

128 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
29929.m004641 Ricinus communis 29929.m004641 I 0.000
SPL11 Arabidopsis thaliana AT1G27360 D 0.000
SPL10 Arabidopsis thaliana AT1G27370 D 0.000
Bo3g141480 Brassica oleracea Bo3g141480 I 0.000
Bo5g051970 Brassica oleracea Bo5g051970 I 0.000
Bo5g051980 Brassica oleracea Bo5g051980 I 0.000
Bo7g049940 Brassica oleracea Bo7g049940 I 0.000
Bostr.15697s0062 Boechera stricta Bostr.15697s0062 I 0.000
Bostr.15697s0063 Boechera stricta Bostr.15697s0063 I 0.000
Bra010949 Brassica rapa Bra010949 I 0.000
Bra030040 Brassica rapa Bra030040 I 0.000
Bra030041 Brassica rapa Bra030041 I 0.000
Bra032822 Brassica rapa Bra032822 I 0.000
Bra032823 Brassica rapa Bra032823 I 0.000
Cagra.8874s0007 Capsella grandiflora Cagra.8874s0007 I 0.000
Cagra.8874s0008 Capsella grandiflora Cagra.8874s0008 I 0.000
Carubv10009364m.g Capsella rubella Carubv10009364m.g I 0.000
Carubv10009367m.g Capsella rubella Carubv10009367m.g I 0.000
Ca_08506 Cicer arietinum Ca_08506 I 0.000
Eucgr.B03500 Eucalyptus grandis Eucgr.B03500 I 0.000
evm.TU.supercontig_43.66 Carica papaya evm.TU.supercontig_43.66 I 0.000
SPL10 Arabidopsis lyrata fgenesh2_kg.1__2893__AT1G27370.2 I 0.000
Lus10006411.g Linum usitatissimum Lus10006411.g I 0.000
Lus10011356.g Linum usitatissimum Lus10011356.g I 0.000
mgf019346m Mimulus guttatus mgf019346m I 0.000
PK16953.1 Cannabis sativa PK16953.1 N 0.000
POPTR_0001s13890 Populus trichocarpa POPTR_0001s13890 I 0.000
POPTR_0003s17120 Populus trichocarpa POPTR_0003s17120 I 0.000
SapurV1A.0056s0240 Salix purpurea SapurV1A.0056s0240 I 0.000
SapurV1A.1271s0060 Salix purpurea SapurV1A.1271s0060 I 0.000
SPL11 Arabidopsis lyrata scaffold_103051.1 I 0.000
Thhalv10007832m.g Eutrema salsugineum Thhalv10007832m.g I 0.000
Thhalv10007882m.g Eutrema salsugineum Thhalv10007882m.g I 0.000
VIT_01s0010g03710 Vitis vinifera VIT_01s0010g03710 I 0.000