BCL11B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000127152 T094903_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11B
M00986_2.00
Homo sapiens
BTHYGGMCV

BGKCCRDAV
PBM
Liu et al.(2018)
BCL11B_23
(Direct) (Direct)
BCL11B
M00987_2.00
Homo sapiens
NNNTGWCCVN

NBGGWCANNN
PBM
Liu et al.(2018)
BCL11B_456
(Direct) (Direct)
BCL11B
M00988_2.00
Homo sapiens
NNTGWCCVN

NBGGWCANN
PBM
Liu et al.(2018)
BCL11B_XL
(Direct) (Direct)
BCL11B
M04453_2.00
Homo sapiens
GTGAACGBNDNNVCTACAC

GTGTAGBNNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_HT-SELEX
(Direct) (Direct)
BCL11B
M04454_2.00
Homo sapiens
GTGAACGBNDNHVCTACAC

GTGTAGBDNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11A
M07926_2.00
Homo sapiens
BTYTCASTTCCYYHH

DDRRGGAASTGARAV
ChIP-seq
Gerstein et al.(2012)
GM12878_BCL11A_HudsonAlpha
0.806 0.947
BCL11A
M08881_2.00
Homo sapiens
BHBYCABTTCCYBHNYN

NRNDVRGGAAVTGRVDV
Misc
Kulakovskiy et al.(2013)
BC11A_HUMAN.H11MO.0.A
0.806 0.947
BCL11A
M10187_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL11A_02
0.806 0.947
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00986_2.00 C2H2 ZF 16 38
M00986_2.00 C2H2 ZF 44 68
M00987_2.00 C2H2 ZF 16 38
M00987_2.00 C2H2 ZF 44 66
M00987_2.00 C2H2 ZF 74 97
M00988_2.00 C2H2 ZF 149 172
M00988_2.00 C2H2 ZF 355 376
M00988_2.00 C2H2 ZF 382 404
M00988_2.00 C2H2 ZF 714 736
M00988_2.00 C2H2 ZF 742 764
M00988_2.00 C2H2 ZF 772 795

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000280435 C2H2 ZF 357 378
ENSP00000280435 C2H2 ZF 384 406
ENSP00000280435 C2H2 ZF 725 747
ENSP00000280435 C2H2 ZF 753 775
ENSP00000280435 C2H2 ZF 783 806
ENSP00000349723 C2H2 ZF 149 172
ENSP00000349723 C2H2 ZF 355 376
ENSP00000349723 C2H2 ZF 382 404
ENSP00000349723 C2H2 ZF 714 736
ENSP00000349723 C2H2 ZF 742 764
ENSP00000349723 C2H2 ZF 772 795
ENSP00000387419 C2H2 ZF 235 257
ENSP00000387419 C2H2 ZF 263 287
ENSP00000387419 C2H2 ZF 602 624
ENSP00000387419 C2H2 ZF 630 652
ENSP00000387419 C2H2 ZF 660 683

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

128 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Aan_R012052 Calypte anna Aan_R012052 N 0.000
Afo_R003860 Aptenodytes forsteri Afo_R003860 N 0.000
Alligator_sinensis_CCG012013.1 Alligator sinensis Alligator_sinensis_CCG012013.1 N 0.000
BAZ2B Ornithorhynchus anatinus ENSOANG00000006146 N 0.000
BAZ2B Monodelphis domestica ENSMODG00000005005 N 0.000
BAZ2B Macaca mulatta ENSMMUG00000006182 N 0.000
BAZ2B Myotis lucifugus ENSMLUG00000001182 N 0.000
baz2b Xenopus tropicalis XB-GENE-964622 N 0.000
BAZ2B Microcebus murinus ENSMICG00000013967 N 0.000
BAZ2B Meleagris gallopavo ENSMGAG00000012953 N 0.000
BAZ2B Oryctolagus cuniculus ENSOCUG00000015150 N 0.000
BAZ2B Otolemur garnettii ENSOGAG00000012349 N 0.000
BAZ2B Pan troglodytes ENSPTRG00000012563 N 0.000
BAZ2B Pteropus vampyrus ENSPVAG00000013042 N 0.000
BAZ2B Sorex araneus ENSSARG00000004075 N 0.000
BAZ2B Sus scrofa ENSSSCG00000015882 N 0.000
BAZ2B Tupaia belangeri ENSTBEG00000016991 N 0.000
BAZ2B Tursiops truncatus ENSTTRG00000001866 N 0.000
BAZ2B Taeniopygia guttata ENSTGUG00000012233 N 0.000
BAZ2B Loxodonta africana ENSLAFG00000014380 N 0.000
BAZ2B Gorilla gorilla ENSGGOG00000016720 N 0.000
BAZ2B Dasypus novemcinctus ENSDNOG00000006145 N 0.000
BAZ2B Cavia porcellus ENSCPOG00000015233 N 0.000
BAZ2B Choloepus hoffmanni ENSCHOG00000007941 N 0.000
BAZ2B Bos taurus ENSBTAG00000020654 N 0.000
BAZ2B Canis familiaris ENSCAFG00000009433 N 0.000
BAZ2B Danio rerio ENSDARG00000082979 N 0.000
BAZ2B Callithrix jacchus ENSCJAG00000015052 N 0.000
Baz2b Dipodomys ordii ENSDORG00000005595 N 0.000
BAZ2B Felis catus ENSFCAG00000007573 N 0.000
BAZ2B Anolis carolinensis ENSACAG00000010585 N 0.000
BAZ2B Gallus gallus ENSGALG00000012579 N 0.000
BAZ2B Homo sapiens ENSG00000123636 N 0.000
BAZ2B Equus caballus ENSECAG00000012235 N 0.000
baz2ba Oryzias latipes ENSORLG00000004260 N 0.000
baz2ba Takifugu rubripes ENSTRUG00000017174 N 0.000
baz2ba Tetraodon nigroviridis ENSTNIG00000009472 N 0.000
baz2ba Danio rerio ENSDARG00000057782 N 0.000
ENSAMEG00000010194 Ailuropoda melanoleuca ENSAMEG00000010194 N 0.000
ENSAMXG00000004622 Astyanax mexicanus ENSAMXG00000004622 N 0.000
ENSAMXG00000009932 Astyanax mexicanus ENSAMXG00000009932 N 0.000
ENSAPLG00000015688 Anas platyrhynchos ENSAPLG00000015688 N 0.000
ENSBTAP00000053510-D1 Bos grunniens ENSBTAP00000053510-D1 N 0.000
ENSCSAG00000015843 Chlorocebus sabaeus ENSCSAG00000015843 N 0.000
ENSFALG00000003242 Ficedula albicollis ENSFALG00000003242 N 0.000
ENSLACG00000002050 Latimeria chalumnae ENSLACG00000002050 N 0.000
ENSLOCG00000006024 Lepisosteus oculatus ENSLOCG00000006024 N 0.000
ENSMPUG00000000490 Mustela putorius furo ENSMPUG00000000490 N 0.000
ENSNLEG00000001067 Nomascus leucogenys ENSNLEG00000001067 N 0.000
ENSOARG00000007352 Ovis aries ENSOARG00000007352 N 0.000
ENSONIG00000008939 Oreochromis niloticus ENSONIG00000008939 N 0.000
ENSPANG00000009095 Papio anubis ENSPANG00000009095 N 0.000
ENSPFOG00000015860 Poecilia formosa ENSPFOG00000015860 N 0.000
ENSPPYG00000012872 Pongo abelii ENSPPYG00000012872 N 0.000
ENSPSIG00000013064 Pelodiscus sinensis ENSPSIG00000013064 N 0.000
ENSSTOG00000009772 Ictidomys tridecemlineatus ENSSTOG00000009772 N 0.000
ENSTSYG00000001627 Tarsius syrichta ENSTSYG00000001627 N 0.000
Gfo_R005657 Geospiza fortis Gfo_R005657 N 0.000
Myotis_brandtii_BAZ2B_10035557 Myotis brandtii Myotis_brandtii_BAZ2B_10035557 N 0.000
Ogr09813 Ophisaurus gracilis Ogr09813 N 0.000
Pvit_15950 Pogona vitticeps Pvit_15950 N 0.000
XP_002933312 Xenopus tropicalis XP_002933312 N 0.000