BCL11B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000127152 T094903_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11B
M00986_2.00
Homo sapiens
BTHYGGMCV

BGKCCRDAV
PBM
Liu et al.(2018)
BCL11B_23
(Direct) (Direct)
BCL11B
M00987_2.00
Homo sapiens
NNNTGWCCVN

NBGGWCANNN
PBM
Liu et al.(2018)
BCL11B_456
(Direct) (Direct)
BCL11B
M00988_2.00
Homo sapiens
NNTGWCCVN

NBGGWCANN
PBM
Liu et al.(2018)
BCL11B_XL
(Direct) (Direct)
BCL11B
M04453_2.00
Homo sapiens
GTGAACGBNDNNVCTACAC

GTGTAGBNNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_HT-SELEX
(Direct) (Direct)
BCL11B
M04454_2.00
Homo sapiens
GTGAACGBNDNHVCTACAC

GTGTAGBDNHNVCGTTCAC
SELEX
Yin et al.(2017)
BCL11B_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BCL11A
M07926_2.00
Homo sapiens
BTYTCASTTCCYYHH

DDRRGGAASTGARAV
ChIP-seq
Gerstein et al.(2012)
GM12878_BCL11A_HudsonAlpha
0.806 0.947
BCL11A
M08881_2.00
Homo sapiens
BHBYCABTTCCYBHNYN

NRNDVRGGAAVTGRVDV
Misc
Kulakovskiy et al.(2013)
BC11A_HUMAN.H11MO.0.A
0.806 0.947
BCL11A
M10187_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$BCL11A_02
0.806 0.947
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00986_2.00 C2H2 ZF 16 38
M00986_2.00 C2H2 ZF 44 68
M00987_2.00 C2H2 ZF 16 38
M00987_2.00 C2H2 ZF 44 66
M00987_2.00 C2H2 ZF 74 97
M00988_2.00 C2H2 ZF 149 172
M00988_2.00 C2H2 ZF 355 376
M00988_2.00 C2H2 ZF 382 404
M00988_2.00 C2H2 ZF 714 736
M00988_2.00 C2H2 ZF 742 764
M00988_2.00 C2H2 ZF 772 795

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000280435 C2H2 ZF 357 378
ENSP00000280435 C2H2 ZF 384 406
ENSP00000280435 C2H2 ZF 725 747
ENSP00000280435 C2H2 ZF 753 775
ENSP00000280435 C2H2 ZF 783 806
ENSP00000349723 C2H2 ZF 149 172
ENSP00000349723 C2H2 ZF 355 376
ENSP00000349723 C2H2 ZF 382 404
ENSP00000349723 C2H2 ZF 714 736
ENSP00000349723 C2H2 ZF 742 764
ENSP00000349723 C2H2 ZF 772 795
ENSP00000387419 C2H2 ZF 235 257
ENSP00000387419 C2H2 ZF 263 287
ENSP00000387419 C2H2 ZF 602 624
ENSP00000387419 C2H2 ZF 630 652
ENSP00000387419 C2H2 ZF 660 683

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

128 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ACYPI007319 Acyrthosiphon pisum ACYPI007319 I 0.763
ENSAMEG00000015813 Ailuropoda melanoleuca ENSAMEG00000015813 I 0.806
Alligator_sinensis_CCG008166.1 Alligator sinensis Alligator_sinensis_CCG008166.1 I 0.806
ENSAPLG00000007735 Anas platyrhynchos ENSAPLG00000007735 I 0.806
ENSAPLG00000006283 Anas platyrhynchos ENSAPLG00000006283 I 0.827
BCL11A Anolis carolinensis ENSACAG00000015159 I 0.806
ENSACAG00000013085 Anolis carolinensis ENSACAG00000013085 I 0.827
AMEC015245 Anopheles melas AMEC015245 I 0.756
Afo_R004626 Aptenodytes forsteri Afo_R004626 I 0.827
Afo_R011357 Aptenodytes forsteri Afo_R011357 I 0.806
ENSAMXG00000004597 Astyanax mexicanus ENSAMXG00000004597 I 0.804
ENSAMXG00000015839 Astyanax mexicanus ENSAMXG00000015839 I 0.827
ENSAMXG00000018130 Astyanax mexicanus ENSAMXG00000018130 I 0.823
BGLB012676 Biomphalaria glabrata BGLB012676 I 0.761
ENSBTAP00000023987-D2 Bos grunniens ENSBTAP00000023987-D2 I 0.806
BCL11B Bos taurus ENSBTAG00000018019 I 0.827
BCL11B Callithrix jacchus ENSCJAG00000006713 I 0.827
BCL11A Callithrix jacchus ENSCJAG00000009226 I 0.806
Aan_R000616 Calypte anna Aan_R000616 I 0.827
Aan_R006276 Calypte anna Aan_R006276 I 0.806
BCL11B Canis familiaris ENSCAFG00000017809 I 0.827
CapteG65449 Capitella teleta CapteG65449 I 0.758
ENSCPOG00000009946 Cavia porcellus ENSCPOG00000009946 I 0.827
BCL11A Cavia porcellus ENSCPOG00000007587 I 0.806
Cmyd_10008592 Chelonia mydas Cmyd_10008592 I 0.806
Cmyd_10012109 Chelonia mydas Cmyd_10012109 I 0.827
ENSCSAG00000010477 Chlorocebus sabaeus ENSCSAG00000010477 I 0.827
im:7142702 Danio rerio ENSDARG00000067727 I 0.823
bcl11ab Danio rerio ENSDARG00000063153 I 0.811
bcl11aa Danio rerio ENSDARG00000061352 I 0.811
BCL11A Dasypus novemcinctus ENSDNOG00000019842 I 0.806
BCL11B Dasypus novemcinctus ENSDNOG00000012677 I 0.827
Bcl11a Dipodomys ordii ENSDORG00000010064 I 0.806
BCL11A Erinaceus europaeus ENSEEUG00000010958 I 0.806
BCL11A Felis catus ENSFCAG00000027154 I 0.806
ENSFALG00000011123 Ficedula albicollis ENSFALG00000011123 I 0.806
ENSGMOG00000012414 Gadus morhua ENSGMOG00000012414 I 0.819
ENSGMOG00000015842 Gadus morhua ENSGMOG00000015842 I 0.816
ENSGALG00000028278 Gallus gallus ENSGALG00000028278 I 0.827
ENSGALG00000011127 Gallus gallus ENSGALG00000011127 I 0.827
ENSGALG00000007866 Gallus gallus ENSGALG00000007866 I 0.806
bcl11aa Gasterosteus aculeatus ENSGACG00000013419 I 0.800
bcl11ba Gasterosteus aculeatus ENSGACG00000013118 I 0.819
im:7142702 Gasterosteus aculeatus ENSGACG00000005537 I 0.823
bcl11ab Gasterosteus aculeatus ENSGACG00000019222 I 0.814
Gfo_R008167 Geospiza fortis Gfo_R008167 I 0.806
Gfo_R006733 Geospiza fortis Gfo_R006733 I 0.827
BCL11B Gorilla gorilla ENSGGOG00000001232 I 0.827
BCL11A Gorilla gorilla ENSGGOG00000007337 I 0.806
HHAL008065-PA Halyomorpha halys HHAL008065-PA I 0.772
BCL11A Homo sapiens ENSG00000119866 D 0.806
ENSSTOG00000021531 Ictidomys tridecemlineatus ENSSTOG00000021531 I 0.827
ENSSTOG00000004523 Ictidomys tridecemlineatus ENSSTOG00000004523 I 0.806
ISCW016418 Ixodes scapularis ISCW016418 I 0.790
ENSLACG00000003560 Latimeria chalumnae ENSLACG00000003560 I 0.806
ENSLOCG00000008679 Lepisosteus oculatus ENSLOCG00000008679 I 0.817
ENSLOCG00000016135 Lepisosteus oculatus ENSLOCG00000016135 I 0.814
LotgiG139415 Lottia gigantea LotgiG139415 I 0.777
BCL11B Loxodonta africana ENSLAFG00000009254 I 0.827
BCL11A Loxodonta africana ENSLAFG00000003101 I 0.806
ENSP00000349723 Macaca fascicularis ENSP00000349723 I 0.823
ENSP00000338774 Macaca fascicularis ENSP00000338774 I 0.806
BCL11B Macaca mulatta ENSMMUG00000003261 I 0.827
ENSMMUG00000011303 Macaca mulatta ENSMMUG00000011303 I 0.806
ENSMEUG00000001829 Macropus eugenii ENSMEUG00000001829 I 0.806
BCL11A Meleagris gallopavo ENSMGAG00000013042 I 0.806
BCL11A Microcebus murinus ENSMICG00000015052 I 0.806
BCL11B Monodelphis domestica ENSMODG00000012964 I 0.827
Bcl11a Mus musculus ENSMUSG00000000861 I 0.806
Bcl11b Mus musculus ENSMUSG00000048251 I 0.827
ENSNLEG00000000711 Nomascus leucogenys ENSNLEG00000000711 I 0.827
Ocbimv22018271m.g Octopus bimaculoides Ocbimv22018271m.g I 0.800
ENSONIG00000002906 Oreochromis niloticus ENSONIG00000002906 I 0.799
ENSONIG00000011060 Oreochromis niloticus ENSONIG00000011060 I 0.817
ENSONIG00000001067 Oreochromis niloticus ENSONIG00000001067 I 0.821
ENSONIG00000018855 Oreochromis niloticus ENSONIG00000018855 I 0.811
BCL11A Ornithorhynchus anatinus ENSOANG00000012402 I 0.806
BCL11B Ornithorhynchus anatinus ENSOANG00000014770 I 0.827
BCL11A Oryctolagus cuniculus ENSOCUG00000023948 I 0.806
ENSOCUG00000024296 Oryctolagus cuniculus ENSOCUG00000024296 I 0.811
bcl11ba Oryzias latipes ENSORLG00000010826 I 0.817
im:7142702 Oryzias latipes ENSORLG00000010488 I 0.825
bcl11aa Oryzias latipes ENSORLG00000001704 I 0.799
bcl11ab Oryzias latipes ENSORLG00000013169 I 0.811
BCL11B Otolemur garnettii ENSOGAG00000033204 I 0.827
BCL11B Pan troglodytes ENSPTRG00000006707 I 0.827
ENSPANG00000004313 Papio anubis ENSPANG00000004313 I 0.827
PHUM606430 Pediculus humanus PHUM606430 I 0.783
ENSPSIG00000013079 Pelodiscus sinensis ENSPSIG00000013079 I 0.827
ENSPSIG00000013644 Pelodiscus sinensis ENSPSIG00000013644 I 0.806
ENSPFOG00000003609 Poecilia formosa ENSPFOG00000003609 I 0.823
ENSPFOG00000007224 Poecilia formosa ENSPFOG00000007224 I 0.819
ENSPFOG00000007302 Poecilia formosa ENSPFOG00000007302 I 0.811
ENSPFOG00000019062 Poecilia formosa ENSPFOG00000019062 I 0.799
Pvit_18645 Pogona vitticeps Pvit_18645 I 0.806
Pvit_09536 Pogona vitticeps Pvit_09536 I 0.827
ENSPPYG00000006131 Pongo abelii ENSPPYG00000006131 I 0.827
BCL11A Pteropus vampyrus ENSPVAG00000000042 I 0.806
BCL11B Pteropus vampyrus ENSPVAG00000015516 I 0.827
Bcl11b Rattus norvegicus ENSRNOG00000005776 I 0.827
Bcl11a Rattus norvegicus ENSRNOG00000007049 I 0.806
RPRC001562 Rhodnius prolixus RPRC001562 I 0.778
Sakowv30026316m.g Saccoglossus kowalevskii Sakowv30026316m.g I 0.820
ENSSHAG00000015804 Sarcophilus harrisii ENSSHAG00000015804 I 0.806
ENSSHAG00000009291 Sarcophilus harrisii ENSSHAG00000009291 I 0.827
SMAR003355 Strigamia maritima SMAR003355 I 0.802
SPU_018909 Strongylocentrotus purpuratus SPU_018909 I 0.801
BCL11A Sus scrofa ENSSSCG00000008392 I 0.806
BCL11B Sus scrofa ENSSSCG00000002507 I 0.827
BCL11B Taeniopygia guttata ENSTGUG00000012711 I 0.827
BCL11A Taeniopygia guttata ENSTGUG00000006790 I 0.806
bcl11ab Takifugu rubripes ENSTRUG00000013751 I 0.811
bcl11aa Takifugu rubripes ENSTRUG00000003815 I 0.799
im:7142702 Takifugu rubripes ENSTRUG00000018074 I 0.821
bcl11ba Takifugu rubripes ENSTRUG00000003531 I 0.817
ENSTSYG00000009153 Tarsius syrichta ENSTSYG00000009153 I 0.806
bcl11ba Tetraodon nigroviridis ENSTNIG00000008283 I 0.817
im:7142702 Tetraodon nigroviridis ENSTNIG00000009693 I 0.808
bcl11ab Tetraodon nigroviridis ENSTNIG00000012076 I 0.811
BCL11B Tursiops truncatus ENSTTRG00000012140 I 0.822
BCL11A Tursiops truncatus ENSTTRG00000006191 I 0.806
BCL11A Vicugna pacos ENSVPAG00000000491 I 0.806
bcl11a Xenopus tropicalis XB-GENE-486641 I 0.806
ENSXMAG00000019910 Xiphophorus maculatus ENSXMAG00000019910 I 0.823
ENSXMAG00000020344 Xiphophorus maculatus ENSXMAG00000020344 I 0.819
ENSXMAG00000007242 Xiphophorus maculatus ENSXMAG00000007242 I 0.802
L798_02171 Zootermopsis nevadensis L798_02171 I 0.773