PRDM12 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000130711 T094913_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PRDM12
M10213_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PRDM12_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000253008 C2H2 ZF 243 265
ENSP00000253008 C2H2 ZF 271 293
ENSP00000253008 C2H2 ZF 299 323

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Alligator_sinensis_CCG011983.1 Alligator sinensis Alligator_sinensis_CCG011983.1 I 0.827
CGI_10016801 Crassostrea gigas CGI_10016801 I 0.792
ENSAMEG00000016234 Ailuropoda melanoleuca ENSAMEG00000016234 I 0.827
ENSAMXG00000007663 Astyanax mexicanus ENSAMXG00000007663 I 0.824
ENSAMXG00000008540 Astyanax mexicanus ENSAMXG00000008540 I 0.824
ENSAPLG00000012403 Anas platyrhynchos ENSAPLG00000012403 I 0.827
PRDM12 Bos taurus ENSBTAG00000023797 I 0.827
PRDM12 Canis familiaris ENSCAFG00000023076 I 0.827
ENSCSAG00000014756 Chlorocebus sabaeus ENSCSAG00000014756 I 0.827
prdm12b Danio rerio ENSDARG00000007430 I 0.824
PRDM12 Dasypus novemcinctus ENSDNOG00000042302 I 0.827
ENSFALG00000001445 Ficedula albicollis ENSFALG00000001445 I 0.827
prdm12b Gasterosteus aculeatus ENSGACG00000016713 I 0.824
PRDM12 Gallus gallus ENSGALG00000003895 I 0.827
ENSGMOG00000011797 Gadus morhua ENSGMOG00000011797 I 0.824
ENSLACG00000017560 Latimeria chalumnae ENSLACG00000017560 I 0.827
PRDM12 Loxodonta africana ENSLAFG00000006979 I 0.827
ENSLOCG00000005429 Lepisosteus oculatus ENSLOCG00000005429 I 0.824
ENSMEUG00000003828 Macropus eugenii ENSMEUG00000003828 I 0.827
PRDM12 Meleagris gallopavo ENSMGAG00000005438 I 0.827
PRDM12 Microcebus murinus ENSMICG00000015480 I 0.827
PRDM12 Monodelphis domestica ENSMODG00000012108 I 0.827
Prdm12 Mus musculus ENSMUSG00000079466 I 0.827
ENSOANG00000001043 Ornithorhynchus anatinus ENSOANG00000001043 I 0.827
PRDM12 Oryctolagus cuniculus ENSOCUG00000008241 I 0.827
PRDM12 Otolemur garnettii ENSOGAG00000007557 I 0.827
ENSONIG00000002871 Oreochromis niloticus ENSONIG00000002871 I 0.824
PRDM12 Ochotona princeps ENSOPRG00000008680 I 0.827
prdm12b Oryzias latipes ENSORLG00000007114 I 0.824
ENSORLG00000017558 Oryzias latipes ENSORLG00000017558 I 0.824
ENSPANG00000025967 Papio anubis ENSPANG00000025967 I 0.827
ENSPFOG00000019841 Poecilia formosa ENSPFOG00000019841 I 0.824
ENSPPYG00000019694 Pongo abelii ENSPPYG00000019694 I 0.827
ENSPSIG00000006739 Pelodiscus sinensis ENSPSIG00000006739 I 0.827
PRDM12 Pan troglodytes ENSPTRG00000021475 I 0.827
PRDM12 Pteropus vampyrus ENSPVAG00000001511 I 0.827
Prdm12 Rattus norvegicus ENSRNOG00000009218 I 0.827
ENSSHAG00000015972 Sarcophilus harrisii ENSSHAG00000015972 I 0.827
PRDM12 Sus scrofa ENSSSCG00000005703 I 0.827
ENSSTOG00000005986 Ictidomys tridecemlineatus ENSSTOG00000005986 I 0.827
ENSTNIG00000005859 Tetraodon nigroviridis ENSTNIG00000005859 I 0.824
ENSTRUG00000013239 Takifugu rubripes ENSTRUG00000013239 I 0.824
prdm12b Takifugu rubripes ENSTRUG00000018659 I 0.827
ENSXMAG00000005537 Xiphophorus maculatus ENSXMAG00000005537 I 0.824
fgenesh2_pg.scaffold_504000008 Branchiostoma floridae fgenesh2_pg.scaffold_504000008 I 0.764
gw.504.9.1 Branchiostoma floridae gw.504.9.1 I 0.764
LotgiG130157 Lottia gigantea LotgiG130157 I 0.777
NEMVEDRAFT_v1g119550 Nematostella vectensis NEMVEDRAFT_v1g119550 I 0.780
Ocbimv22004421m.g Octopus bimaculoides Ocbimv22004421m.g I 0.778
Ogr15453 Ophisaurus gracilis Ogr15453 I 0.827
Pvit_04639 Pogona vitticeps Pvit_04639 I 0.827
Sakowv30035316m.g Saccoglossus kowalevskii Sakowv30035316m.g I 0.816
TriadG14897 Trichoplax adhaerens TriadG14897 I 0.780
prdm12 Xenopus tropicalis XB-GENE-953729 I 0.827
prdm12.L Xenopus laevis XB-GENE-953734 I 0.827