EGR4 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000135625 T094930_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
EGR4
M02889_2.00
Homo sapiens
NHMCGCCCACGCAHHN

NDDTGCGTGGGCGKDN
SELEX
Jolma et al.(2013)
EGR4_1
(Direct) (Direct)
EGR4
M02890_2.00
Homo sapiens
NHMCGCCCACGCAHWH

DWDTGCGTGGGCGKDN
SELEX
Jolma et al.(2013)
EGR4_2
(Direct) (Direct)
EGR4
M04461_2.00
Homo sapiens
HMCGCCCACGCAH

DTGCGTGGGCGKD
SELEX
Yin et al.(2017)
EGR4_eDBD_HT-SELEX
(Direct) (Direct)
EGR4
M04462_2.00
Homo sapiens
HMCGCCCMCGCRH

DYGCGKGGGCGKD
SELEX
Yin et al.(2017)
EGR4_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
EGR4
M10216_2.00
Homo sapiens
MCRCCCACGCAW

WTGCGTGGGYGK
Transfac
Matys et al.(2006)
V$NGFIC_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Egr1
M01864_2.00
Mus musculus
CCCMCGYNN

NNRCGKGGG
PBM
Weirauch et al.(2014)
pTH5337
0.804 0.812
Egr1
M00375_2.00
Mus musculus
NCCYMCDNN

NNHGKRGGN
PBM
Berger et al.(2006)
Zif268
0.804 0.812
EGR1
M02883_2.00
Homo sapiens
NMCGCCCMCGCANN

NNTGCGKGGGCGKN
SELEX
Jolma et al.(2013)
EGR1_1
0.804 0.812
EGR1
M02884_2.00
Homo sapiens
HMCGCCCACGCAHW

WDTGCGTGGGCGKD
SELEX
Jolma et al.(2013)
EGR1_2
0.804 0.812
Egr1
M02932_2.00
Mus musculus
HHMCGCCCMCBCAHHH

DDDTGVGKGGGCGKDD
SELEX
Jolma et al.(2013)
Egr1_1
0.804 0.812
EGR1
M04437_2.00
Homo sapiens
NNCRCCCMCRCNN

NNGYGKGGGYGNN
SELEX
Yin et al.(2017)
EGR1_eDBD_HT-SELEX
0.804 0.812
Egr1
M05860_2.00
Mus musculus
NNMCRCCCMCGCN

NGCGKGGGYGKNN
SMiLE-seq
Isakova et al.(2017)
EGR1
0.804 0.812
EGR1
M07927_2.00
Homo sapiens
NVBNNNNBCCGCCCMCGCNB

VNGCGKGGGCGGVNNNNVBN
ChIP-seq
Gerstein et al.(2012)
GM12878_EGR1_HudsonAlpha
0.804 0.812
EGR1
M07928_2.00
Homo sapiens
BNCCGCCCMCGCNBB

VVNGCGKGGGCGGNV
ChIP-seq
Gerstein et al.(2012)
H1-hESC_EGR1_HudsonAlpha
0.804 0.812
EGR1
M07929_2.00
Homo sapiens
NNNNNNBNNCCRCCCMCGCN

NGCGKGGGYGGNNVNNNNNN
ChIP-seq
Gerstein et al.(2012)
K562_EGR1_HudsonAlpha
0.804 0.812
EGR1
M08882_2.00
Homo sapiens
BHNCCDCCCMCDCHBNB

VNVDGHGKGGGHGGNDV
Misc
Kulakovskiy et al.(2013)
EGR1_HUMAN.H11MO.0.A
0.804 0.812
Egr1
M08996_2.00
Mus musculus
YYCCRCCCMCGCNB

VNGCGKGGGYGGRR
Misc
Kulakovskiy et al.(2013)
EGR1_MOUSE.H11MO.0.A
0.804 0.812
EGR1
M09506_2.00
Homo sapiens
CRCCCMCRCA

TGYGKGGGYG
Misc
Heinz et al.(2010)
K562-Egr1_GSE32465
0.804 0.812
EGR1
M10188_2.00
Homo sapiens
MCGCCYACGCAW

WTGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR1_01
0.804 0.812
EGR1
M10189_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_02
0.804 0.812
EGR1
M10190_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_09
0.804 0.812
EGR1
M10191_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_11
0.804 0.812
EGR1
M10192_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_12
0.804 0.812
EGR1
M10193_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_13
0.804 0.812
EGR1
M10194_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_15
0.804 0.812
EGR1
M10195_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_Q3
0.804 0.812
EGR1
M10196_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR1_Q6
0.804 0.812
EGR1
M04438_2.00
Homo sapiens
NHCDCCCMCNYNN

NNRNGKGGGHGDN
SELEX
Yin et al.(2017)
EGR1_eDBD_Methyl-HT-SELEX
0.804 0.812
Egr3
M00776_2.00
Mus musculus
HHDCCCMCDN

NHGKGGGHDD
PBM
Weirauch et al.(2013)
pTH2820
0.796 0.783
EGR3
M02915_2.00
Homo sapiens
NHMCGCCCMCGCAHN

NDTGCGKGGGCGKDN
SELEX
Jolma et al.(2013)
EGR3_1
0.796 0.783
Egr3
M02931_2.00
Mus musculus
HMCGCCCACGCAHWN

NWDTGCGTGGGCGKD
SELEX
Jolma et al.(2013)
Egr3_1
0.796 0.783
EGR3
M04583_2.00
Homo sapiens
HMCGCCCACGCRH

DYGCGTGGGCGKD
SELEX
Yin et al.(2017)
EGR3_FL_HT-SELEX
0.796 0.783
EGR3
M08349_2.00
Homo sapiens
CDCCYCCDC

GHGGRGGHG
ChIP-seq
Schmitges et al.(2016)
Q06889_1-3.RCADE
0.796 0.783
EGR3
M10279_2.00
Homo sapiens
MCGCCYACGCWN

NWGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR3_01
0.796 0.783
EGR3
M10280_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR3_Q3
0.796 0.783
EGR3
M10281_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR3_Q6
0.796 0.783
EGR3
M04584_2.00
Homo sapiens
NMCGCCCACGCRH

DYGCGTGGGCGKN
SELEX
Yin et al.(2017)
EGR3_FL_Methyl-HT-SELEX
0.796 0.783
sr
M06072_2.00
Drosophila melanogaster
HVMCGCCCMCVYMH

DKRBGKGGGCGKBD
B1H
Zhu et al.(2011)
sr_SANGER_5_FBgn0003499
0.790 0.797
sr
M06073_2.00
Drosophila melanogaster
NNMCRCCCMCVHNN

NNDBGKGGGYGKNN
B1H
Zhu et al.(2011)
sr_SOLEXA_5_FBgn0003499
0.790 0.797
EGR2
M00233_2.00
Homo sapiens
HDCCCMCDBN

NVHGKGGGHD
PBM
Barrera et al.(2016)
EGR2_REF
0.784 0.783
Egr2
M00778_2.00
Mus musculus
YRCCCMCGYN

NRCGKGGGYR
PBM
Weirauch et al.(2013)
pTH3091
0.784 0.783
EGR2
M02885_2.00
Homo sapiens
MCGCCCACGCD

HGCGTGGGCGK
SELEX
Jolma et al.(2013)
EGR2_1
0.784 0.783
EGR2
M02886_2.00
Homo sapiens
NNMCGCCCACGCDNN

NNHGCGTGGGCGKNN
SELEX
Jolma et al.(2013)
EGR2_2
0.784 0.783
EGR2
M04439_2.00
Homo sapiens
HMCRCCCACGCNN

NNGCGTGGGYGKD
SELEX
Yin et al.(2017)
EGR2_FL_HT-SELEX
0.784 0.783
EGR2
M08302_2.00
Homo sapiens
CDCCCMCDC

GHGKGGGHG
ChIP-seq
Schmitges et al.(2016)
P11161_1-3.RCADE
0.784 0.783
EGR2
M08884_2.00
Homo sapiens
YYCCDCCCMCDCHYHYHY

RDRDRDGHGKGGGHGGRR
Misc
Kulakovskiy et al.(2013)
EGR2_HUMAN.H11MO.0.A
0.784 0.783
Egr2
M08994_2.00
Mus musculus
BHYCCDCCCMCDCN

NGHGKGGGHGGRDV
Misc
Kulakovskiy et al.(2013)
EGR2_MOUSE.H11MO.0.A
0.784 0.783
Egr2
M09515_2.00
Mus musculus
NMCRCCCACDSN

NSHGTGGGYGKN
Misc
Heinz et al.(2010)
Thymocytes-Egr2_GSE34254
0.784 0.783
EGR2
M10197_2.00
Homo sapiens
MCGCCYACGCAH

DTGCGTRGGCGK
Transfac
Matys et al.(2006)
V$EGR2_01
0.784 0.783
EGR2
M10198_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR2_Q4
0.784 0.783
EGR2
M10199_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$EGR2_Q6
0.784 0.783
EGR2
M04440_2.00
Homo sapiens
NMCGCCCACRCRN

NYGYGTGGGCGKN
SELEX
Yin et al.(2017)
EGR2_FL_Methyl-HT-SELEX
0.784 0.783
EGR2
M00232_2.00
Homo sapiens
NHMCGCCYNN

NNRGGCGKDN
PBM
Barrera et al.(2016)
EGR2_R409W
0.782 0.768
egrh-1
M00622_2.00
Caenorhabditis elegans
CSCCCMCR

YGKGGGSG
PBM
Narasimhan et al.(2015)
pTH9317
0.774 0.783
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000419687 C2H2 ZF 380 404
ENSP00000419687 C2H2 ZF 410 432
ENSP00000419687 C2H2 ZF 438 460
ENSP00000445626 C2H2 ZF 483 507
ENSP00000445626 C2H2 ZF 513 535
ENSP00000445626 C2H2 ZF 541 563

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

348 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
F775_25077 Aegilops tauschii F775_25077 I 0.000
AMTR_s00040p00057740 Amborella trichopoda AMTR_s00040p00057740 I 0.000
Al_scaffold_0007_1421 Arabidopsis lyrata Al_scaffold_0007_1421 N 0.000
scaffold_105455.1 Arabidopsis lyrata scaffold_105455.1 N 0.000
fgenesh2_kg.1__328__AT1G03970.1 Arabidopsis lyrata fgenesh2_kg.1__328__AT1G03970.1 N 0.000
GBF4 Arabidopsis thaliana AT1G03970 N 0.000
Bostr.26675s0358 Boechera stricta Bostr.26675s0358 N 0.000
BRADI2G24120 Brachypodium distachyon BRADI2G24120 I 0.000
BRADI2G56096 Brachypodium distachyon BRADI2G56096 I 0.000
Bo5g004230 Brassica oleracea Bo5g004230 N 0.000
Bo7g067030 Brassica oleracea Bo7g067030 N 0.000
Bra015281 Brassica rapa Bra015281 N 0.000
PK16522.1 Cannabis sativa PK16522.1 N 0.000
Cagra.1671s0014 Capsella grandiflora Cagra.1671s0014 N 0.000
Carubv10011573m.g Capsella rubella Carubv10011573m.g N 0.000
evm.TU.supercontig_21.207 Carica papaya evm.TU.supercontig_21.207 N 0.000
Ca_04375 Cicer arietinum Ca_04375 N 0.000
Ciclev10002059m.g Citrus clementina Ciclev10002059m.g I 0.000
orange1.1g025985m.g Citrus sinensis orange1.1g025985m.g I 0.000
Cucsa.363740 Cucumis sativus Cucsa.363740 I 0.000
Thhalv10003246m.g Eutrema salsugineum Thhalv10003246m.g N 0.000
Thhalv10009710m.g Eutrema salsugineum Thhalv10009710m.g N 0.000
GLYMA08G08220 Glycine max GLYMA08G08220 N 0.000
GLYMA10G36820 Glycine max GLYMA10G36820 N 0.000
Gorai.005G237400 Gossypium raimondii Gorai.005G237400 I 0.000
Gorai.005G078500 Gossypium raimondii Gorai.005G078500 N 0.000
MLOC_20326 Hordeum vulgare MLOC_20326 N 0.000
MLOC_53321 Hordeum vulgare MLOC_53321 I 0.000
MLOC_64571 Hordeum vulgare MLOC_64571 I 0.000
LPERR05G14180 Leersia perrieri LPERR05G14180 I 0.000
LPERR01G33060 Leersia perrieri LPERR01G33060 I 0.000
chr5.CM0052.120.nc Lotus japonicus chr5.CM0052.120.nc N 0.000
MTR_1g098590 Medicago truncatula MTR_1g098590 N 0.000
mgf008848m Mimulus guttatus mgf008848m N 0.000
GSMUA_Achr10G10440_001 Musa acuminata GSMUA_Achr10G10440_001 I 0.000
GSMUA_Achr3G22470_001 Musa acuminata GSMUA_Achr3G22470_001 I 0.000
GSMUA_Achr9G08900_001 Musa acuminata GSMUA_Achr9G08900_001 N 0.000
OBART05G17920 Oryza barthii OBART05G17920 I 0.000
OBART01G38510 Oryza barthii OBART01G38510 I 0.000
OB05G25740 Oryza brachyantha OB05G25740 I 0.000
ORGLA05G0154900 Oryza glaberrima ORGLA05G0154900 I 0.000
ORGLA01G0323500 Oryza glaberrima ORGLA01G0323500 I 0.000
OGLUM01G42750 Oryza glumaepatula OGLUM01G42750 I 0.000
OGLUM05G18920 Oryza glumaepatula OGLUM05G18920 I 0.000
BGIOSGA019930 Oryza indica BGIOSGA019930 I 0.000
OLONG_006755 Oryza longistaminata OLONG_006755 I 0.000
OLONG_001053 Oryza longistaminata OLONG_001053 I 0.000
OMERI01G35430 Oryza meridionalis OMERI01G35430 I 0.000
OMERI05G15500 Oryza meridionalis OMERI05G15500 I 0.000
ONIVA05G18780 Oryza nivara ONIVA05G18780 I 0.000
ONIVA01G43200 Oryza nivara ONIVA01G43200 I 0.000
OPUNC01G37310 Oryza punctata OPUNC01G37310 I 0.000
ORUFI05G19090 Oryza rufipogon ORUFI05G19090 I 0.000
ORUFI12G20810 Oryza rufipogon ORUFI12G20810 I 0.000
ORUFI01G41890 Oryza rufipogon ORUFI01G41890 I 0.000
OS05G0437700 Oryza sativa OS05G0437700 I 0.000
BZIP46 Oryza sativa OS06G0211200 I 0.000
LOC_Os05g36160 Oryza sativa LOC_Os05g36160 D 0.000
OS01G0867300 Oryza sativa OS01G0867300 I 0.000
Pavir.Da01931 Panicum virgatum Pavir.Da01931 I 0.000
Pavir.Ea03718 Panicum virgatum Pavir.Ea03718 I 0.000
Pavir.J36143 Panicum virgatum Pavir.J36143 I 0.000
Pavir.J06257 Panicum virgatum Pavir.J06257 I 0.000
Pavir.J05659 Panicum virgatum Pavir.J05659 I 0.000
Pavir.J00256 Panicum virgatum Pavir.J00256 I 0.000
POPTR_0002s06800 Populus trichocarpa POPTR_0002s06800 I 0.000
POPTR_0005s21500 Populus trichocarpa POPTR_0005s21500 I 0.000
SapurV1A.0134s0060 Salix purpurea SapurV1A.0134s0060 I 0.000
SapurV1A.0625s0150 Salix purpurea SapurV1A.0625s0150 I 0.000
Si006889m.g Setaria italica Si006889m.g I 0.000
Sb04g034190 Sorghum bicolor Sb04g034190 I 0.000
Sb03g040970 Sorghum bicolor Sb03g040970 I 0.000
Sb09g021580 Sorghum bicolor Sb09g021580 I 0.000
TCM_035623 Theobroma cacao TCM_035623 N 0.000
TRAES3BF019000220CFD_g Triticum aestivum TRAES3BF019000220CFD_g I 0.000
Traes_7DS_C6A3C10A6 Triticum aestivum Traes_7DS_C6A3C10A6 N 0.000
TRIUR3_23754 Triticum urartu TRIUR3_23754 N 0.000
TRIUR3_19588 Triticum urartu TRIUR3_19588 I 0.000
VIT_18s0072g00470 Vitis vinifera VIT_18s0072g00470 N 0.000
VIT_12s0055g00420 Vitis vinifera VIT_12s0055g00420 I 0.000
GRMZM2G438293 Zea mays GRMZM2G438293 N 0.000
GRMZM5G858197 Zea mays GRMZM5G858197 I 0.000
GRMZM2G129247 Zea mays GRMZM2G129247 N 0.000
GRMZM2G033413 Zea mays GRMZM2G033413 I 0.000
GRMZM2G132868 Zea mays GRMZM2G132868 I 0.000