ZIC5 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000139800 T094941_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZIC5
M04471_2.00
Homo sapiens
NKACCCCCCGCTGHGH

DCDCAGCGGGGGGTMN
SELEX
Yin et al.(2017)
ZIC5_eDBD_HT-SELEX
(Direct) (Direct)
ZIC5
M04472_2.00
Homo sapiens
NKACCCCCYGCTGTGM

KCACAGCRGGGGGTMN
SELEX
Yin et al.(2017)
ZIC5_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Zic5
M00780_2.00
Mus musculus
BRCCCCCYDS

SHRGGGGGYV
PBM
Weirauch et al.(2013)
pTH2818
0.818 0.991
Zic3
M00151_2.00
Mus musculus
NCMYVBNRNB

VNYNVBRKGN
PBM
Badis et al.(2009)
Zic3_3119
0.763 0.864
ZIC3
M02894_2.00
Homo sapiens
BACCCCCYGCKGYGH

DCRCMGCRGGGGGTV
SELEX
Jolma et al.(2013)
ZIC3_1
0.763 0.864
Zic3
M02936_2.00
Mus musculus
KRCCCCCYGCTGYGH

DCRCAGCRGGGGGYM
SELEX
Jolma et al.(2013)
Zic3_1
0.763 0.864
ZIC3
M04491_2.00
Homo sapiens
VGACCCCCYGCTGTGM

KCACAGCRGGGGGTCB
SELEX
Yin et al.(2017)
ZIC3_eDBD_HT-SELEX
0.763 0.864
ZIC3
M04493_2.00
Homo sapiens
BACCCCCYGCTGYGH

DCRCAGCRGGGGGTV
SELEX
Yin et al.(2017)
ZIC3_FL_HT-SELEX
0.763 0.864
ZIC3
M08902_2.00
Homo sapiens
NVVYHCCTGCTGDGN

NCHCAGCAGGDRBBN
Misc
Kulakovskiy et al.(2013)
ZIC3_HUMAN.H11MO.0.B
0.763 0.864
Zic3
M09013_2.00
Mus musculus
NVVYHCCTGCTGDGN

NCHCAGCAGGDRBBN
Misc
Kulakovskiy et al.(2013)
ZIC3_MOUSE.H11MO.0.A
0.763 0.864
ZIC3
M10229_2.00
Homo sapiens
VRBCMCCCN

NGGGKGVYB
Transfac
Matys et al.(2006)
V$ZIC3_01
0.763 0.864
Zic3
M10359_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZIC3_07
0.763 0.864
ZIC3
M04492_2.00
Homo sapiens
NKACCCCCTGCTGTGM

KCACAGCAGGGGGTMN
SELEX
Yin et al.(2017)
ZIC3_eDBD_Methyl-HT-SELEX
0.763 0.864
ZIC3
M04494_2.00
Homo sapiens
BRCCCCCTGCTGTGM

KCACAGCAGGGGGYV
SELEX
Yin et al.(2017)
ZIC3_FL_Methyl-HT-SELEX
0.763 0.864
Zic1
M00137_2.00
Mus musculus
NCMYVBNGNK

MNCNVBRKGN
PBM
Badis et al.(2009)
Zic1_0991
0.759 0.900
ZIC1
M02893_2.00
Homo sapiens
KRCCCCCYGCTGYG

CRCAGCRGGGGGYM
SELEX
Jolma et al.(2013)
ZIC1_1
0.759 0.900
ZIC1
M04485_2.00
Homo sapiens
BVCCMCCYGYHGYGH

DCRCDRCRGGKGGBV
SELEX
Yin et al.(2017)
ZIC1_eDBD_HT-SELEX
0.759 0.900
ZIC1
M04487_2.00
Homo sapiens
BVCCCCCYGCTGYGH

DCRCAGCRGGGGGBV
SELEX
Yin et al.(2017)
ZIC1_FL_HT-SELEX
0.759 0.900
ZIC1
M08900_2.00
Homo sapiens
BMSCHCCCM

KGGGDGSKV
Misc
Kulakovskiy et al.(2013)
ZIC1_HUMAN.H11MO.0.B
0.759 0.900
Zic1
M08990_2.00
Mus musculus
BMSCHCCCM

KGGGDGSKV
Misc
Kulakovskiy et al.(2013)
ZIC1_MOUSE.H11MO.0.B
0.759 0.900
ZIC1
M10226_2.00
Homo sapiens
KRCNMMCYV

BRGKKNGTM
Transfac
Matys et al.(2006)
V$ZIC1_01
0.759 0.900
ZIC1
M10227_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZIC1_Q2
0.759 0.900
ZIC1
M04486_2.00
Homo sapiens
BACCCCCYRCTGTGM

KCACAGYRGGGGGTV
SELEX
Yin et al.(2017)
ZIC1_eDBD_Methyl-HT-SELEX
0.759 0.900
ZIC1
M04488_2.00
Homo sapiens
BRCCCCCTGCTGTGH

DCACAGCAGGGGGYV
SELEX
Yin et al.(2017)
ZIC1_FL_Methyl-HT-SELEX
0.759 0.900
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000267294 C2H2 ZF 431 449
ENSP00000267294 C2H2 ZF 458 485
ENSP00000267294 C2H2 ZF 491 515
ENSP00000267294 C2H2 ZF 521 545
ENSP00000267294 C2H2 ZF 551 575

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

159 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZIC1 Homo sapiens ENSG00000152977 D 0.759
Zic1 Mus musculus ENSMUSG00000032368 D 0.759
Zic3 Mus musculus ENSMUSG00000067860 D 0.763
ZIC3 Homo sapiens ENSG00000156925 D 0.763
ENSPTRG00000034285 Pan troglodytes ENSPTRG00000034285 I 0.827
ZIC3 Pteropus vampyrus ENSPVAG00000011652 I 0.763
Zic5 Rattus norvegicus ENSRNOG00000014358 I 0.827
Zic1 Rattus norvegicus ENSRNOG00000014644 I 0.759
ZIC1 Pan troglodytes ENSPTRG00000015501 I 0.759
Zic4 Rattus norvegicus ENSRNOG00000014871 I 0.757
Zic3 Rattus norvegicus ENSRNOG00000000861 I 0.763
ENSSHAG00000015091 Sarcophilus harrisii ENSSHAG00000015091 I 0.762
ZIC1 Sus scrofa ENSSSCG00000011692 I 0.759
zic4 Tetraodon nigroviridis ENSTNIG00000012759 I 0.756
zic1 Tetraodon nigroviridis ENSTNIG00000012758 I 0.757
ZIC1 Taeniopygia guttata ENSTGUG00000008838 I 0.759
ENSTGUG00000008837 Taeniopygia guttata ENSTGUG00000008837 I 0.765
ENSSTOG00000027399 Ictidomys tridecemlineatus ENSSTOG00000027399 I 0.827
ENSSTOG00000024153 Ictidomys tridecemlineatus ENSSTOG00000024153 I 0.763
ENSSTOG00000000952 Ictidomys tridecemlineatus ENSSTOG00000000952 I 0.759
ZIC3 Sus scrofa ENSSSCG00000012705 I 0.763
ENSPSIG00000009089 Pelodiscus sinensis ENSPSIG00000009089 I 0.823
ENSPSIG00000005002 Pelodiscus sinensis ENSPSIG00000005002 I 0.759
ENSONIG00000006787 Oreochromis niloticus ENSONIG00000006787 I 0.816
ENSONIG00000006788 Oreochromis niloticus ENSONIG00000006788 I 0.762
zic3 Oryzias latipes ENSORLG00000001654 I 0.763
zic1 Oryzias latipes ENSORLG00000010050 I 0.769
zic4 Oryzias latipes ENSORLG00000010055 I 0.756
zic2b Oryzias latipes ENSORLG00000011117 I 0.762
zic5 Oryzias latipes ENSORLG00000011124 I 0.816
ENSPANG00000005804 Papio anubis ENSPANG00000005804 I 0.759
ENSPANG00000011357 Papio anubis ENSPANG00000011357 I 0.763
ENSPANG00000018055 Papio anubis ENSPANG00000018055 I 0.827
ZIC5 Procavia capensis ENSPCAG00000011845 I 0.827
ENSPFOG00000012158 Poecilia formosa ENSPFOG00000012158 I 0.816
ENSPFOG00000012982 Poecilia formosa ENSPFOG00000012982 I 0.763
ENSPFOG00000013981 Poecilia formosa ENSPFOG00000013981 I 0.771
ENSPFOG00000014007 Poecilia formosa ENSPFOG00000014007 I 0.756
ENSPPYG00000020775 Pongo abelii ENSPPYG00000020775 I 0.763
ENSPSIG00000004881 Pelodiscus sinensis ENSPSIG00000004881 I 0.760
ENSONIG00000005878 Oreochromis niloticus ENSONIG00000005878 I 0.756
zic2b Tetraodon nigroviridis ENSTNIG00000014979 I 0.766
zic5 Tetraodon nigroviridis ENSTNIG00000014980 I 0.806
ENSP00000282928 Macaca fascicularis ENSP00000282928 I 0.759
ENSP00000287538-D1 Bos grunniens ENSP00000287538-D1 I 0.763
ENSP00000287538 Macaca fascicularis ENSP00000287538 I 0.763
Gfo_R005436 Geospiza fortis Gfo_R005436 I 0.759
Myotis_brandtii_ZIC1_10009541 Myotis brandtii Myotis_brandtii_ZIC1_10009541 I 0.759
Myotis_brandtii_ZIC3_10005513 Myotis brandtii Myotis_brandtii_ZIC3_10005513 I 0.763
Ogr15027 Ophisaurus gracilis Ogr15027 I 0.762
Ogr15030 Ophisaurus gracilis Ogr15030 I 0.759
Pvit_01478 Pogona vitticeps Pvit_01478 I 0.762
Pvit_01479 Pogona vitticeps Pvit_01479 I 0.759
Pvit_14046 Pogona vitticeps Pvit_14046 I 0.810
estExt_gwp.C_400285 Branchiostoma floridae estExt_gwp.C_400285 I 0.768
zic4 Xenopus tropicalis XB-GENE-1033015 I 0.762
zic4.L Xenopus laevis XB-GENE-1033019 I 0.762
zic5 Xenopus tropicalis XB-GENE-480775 I 0.817
zic1.S Xenopus laevis XB-GENE-864815 I 0.765
zic5.S Xenopus laevis XB-GENE-865408 I 0.803
ENSP00000282928-D1 Bos grunniens ENSP00000282928-D1 I 0.759
Cmyd_10020767 Chelonia mydas Cmyd_10020767 I 0.759
Alligator_sinensis_CCG012205.1 Alligator sinensis Alligator_sinensis_CCG012205.1 I 0.762
zic5 Takifugu rubripes ENSTRUG00000011797 I 0.806
zic1 Takifugu rubripes ENSTRUG00000017760 I 0.759
zic4 Takifugu rubripes ENSTRUG00000017765 I 0.756
ENSTSYG00000003356 Tarsius syrichta ENSTSYG00000003356 I 0.763
ZIC1 Tursiops truncatus ENSTTRG00000014350 I 0.759
ENSXMAG00000009162 Xiphophorus maculatus ENSXMAG00000009162 I 0.756
ENSXMAG00000009164 Xiphophorus maculatus ENSXMAG00000009164 I 0.762
ENSXMAG00000010996 Xiphophorus maculatus ENSXMAG00000010996 I 0.816
ENSXMAG00000013404 Xiphophorus maculatus ENSXMAG00000013404 I 0.763
L798_08424 Zootermopsis nevadensis L798_08424 I 0.759
LotgiG193238 Lottia gigantea LotgiG193238 I 0.762
PHUM303860 Pediculus humanus PHUM303860 I 0.759
SMAR005380 Strigamia maritima SMAR005380 I 0.766
SPU_028583 Strongylocentrotus purpuratus SPU_028583 I 0.764
SPU_030070 Strongylocentrotus purpuratus SPU_030070 I 0.764
Aan_R013349 Calypte anna Aan_R013349 I 0.759
Alligator_sinensis_CCG012204.1 Alligator sinensis Alligator_sinensis_CCG012204.1 I 0.759
XP_002937379 Xenopus tropicalis XP_002937379 I 0.759
ENSONIG00000005875 Oreochromis niloticus ENSONIG00000005875 I 0.771
CGI_10016116 Crassostrea gigas CGI_10016116 I 0.786
ENSCSAG00000017495 Chlorocebus sabaeus ENSCSAG00000017495 I 0.827
zic1 Danio rerio ENSDARG00000015567 I 0.759
zic5 Danio rerio ENSDARG00000016022 I 0.811
zic4 Danio rerio ENSDARG00000031307 I 0.756
zic3 Danio rerio ENSDARG00000071497 I 0.761
ZIC3 Dasypus novemcinctus ENSDNOG00000006192 I 0.763
ZIC5 Dasypus novemcinctus ENSDNOG00000046390 I 0.827
ZIC1 Dasypus novemcinctus ENSDNOG00000047101 I 0.759
ENSDORG00000014318 Dipodomys ordii ENSDORG00000014318 I 0.763
ZIC3 Equus caballus ENSECAG00000013318 I 0.763
ENSECAG00000013406 Equus caballus ENSECAG00000013406 I 0.790
ZIC5 Erinaceus europaeus ENSEEUG00000002965 I 0.827
ZIC3 Echinops telfairi ENSETEG00000018846 I 0.763
ENSFALG00000007091 Ficedula albicollis ENSFALG00000007091 I 0.762
ENSFALG00000007094 Ficedula albicollis ENSFALG00000007094 I 0.759
ZIC1 Felis catus ENSFCAG00000007061 I 0.759
ZIC3 Felis catus ENSFCAG00000025684 I 0.763
ENSCSAG00000011409 Chlorocebus sabaeus ENSCSAG00000011409 I 0.759
ENSCSAG00000007453 Chlorocebus sabaeus ENSCSAG00000007453 I 0.763
ZIC1 Anolis carolinensis ENSACAG00000006947 I 0.759
ENSAMEG00000002149 Ailuropoda melanoleuca ENSAMEG00000002149 I 0.759
ENSAMEG00000002684 Ailuropoda melanoleuca ENSAMEG00000002684 I 0.763
ENSAMEG00000004500 Ailuropoda melanoleuca ENSAMEG00000004500 I 0.827
ENSAMXG00000002323 Astyanax mexicanus ENSAMXG00000002323 I 0.821
ENSAMXG00000010931 Astyanax mexicanus ENSAMXG00000010931 I 0.759
ENSAMXG00000010941 Astyanax mexicanus ENSAMXG00000010941 I 0.766
ENSAPLG00000002960 Anas platyrhynchos ENSAPLG00000002960 I 0.759
ENSAPLG00000003027 Anas platyrhynchos ENSAPLG00000003027 I 0.763
ZIC1 Bos taurus ENSBTAG00000014751 I 0.759
ZIC3 Bos taurus ENSBTAG00000021413 I 0.763
ZIC5 Canis familiaris ENSCAFG00000005834 I 0.827
ZIC3 Canis familiaris ENSCAFG00000018979 I 0.763
ZIC1 Callithrix jacchus ENSCJAG00000001524 I 0.759
ZIC3 Callithrix jacchus ENSCJAG00000013792 I 0.763
ENSCJAG00000020987 Callithrix jacchus ENSCJAG00000020987 I 0.827
ENSCPOG00000002374 Cavia porcellus ENSCPOG00000002374 I 0.763
CapteG160442 Capitella teleta CapteG160442 I 0.768
zic2b Gasterosteus aculeatus ENSGACG00000001901 I 0.758
zic1 Gasterosteus aculeatus ENSGACG00000003678 I 0.759
ZIC1 Macaca mulatta ENSMMUG00000004742 I 0.759
ZIC5 Macaca mulatta ENSMMUG00000014821 I 0.827
ZIC5 Monodelphis domestica ENSMODG00000007733 I 0.825
ENSMODG00000021250 Monodelphis domestica ENSMODG00000021250 I 0.760
ENSMPUG00000001786 Mustela putorius furo ENSMPUG00000001786 I 0.763
ENSMPUG00000011764 Mustela putorius furo ENSMPUG00000011764 I 0.759
Zic4 Mus musculus ENSMUSG00000036972 I 0.757
ENSNLEG00000002407 Nomascus leucogenys ENSNLEG00000002407 I 0.759
ENSNLEG00000003005 Nomascus leucogenys ENSNLEG00000003005 I 0.763
ENSNLEG00000007807 Nomascus leucogenys ENSNLEG00000007807 I 0.827
ENSOARG00000004385 Ovis aries ENSOARG00000004385 I 0.827
ENSOARG00000005434 Ovis aries ENSOARG00000005434 I 0.759
ENSOARG00000010774 Ovis aries ENSOARG00000010774 I 0.763
ZIC3 Oryctolagus cuniculus ENSOCUG00000009358 I 0.763
ZIC4 Otolemur garnettii ENSOGAG00000007463 I 0.762
ZIC1 Otolemur garnettii ENSOGAG00000007465 I 0.759
ZIC3 Otolemur garnettii ENSOGAG00000011700 I 0.763
ZIC3 Myotis lucifugus ENSMLUG00000011691 I 0.763
ZIC1 Microcebus murinus ENSMICG00000014401 I 0.759
zic4 Gasterosteus aculeatus ENSGACG00000003685 I 0.756
ENSGALG00000006811 Gallus gallus ENSGALG00000006811 I 0.759
ZIC1 Gorilla gorilla ENSGGOG00000001101 I 0.759
ZIC3 Gorilla gorilla ENSGGOG00000011914 I 0.763
ZIC5 Gorilla gorilla ENSGGOG00000022385 I 0.827
ENSGMOG00000001788 Gadus morhua ENSGMOG00000001788 I 0.759
ENSGMOG00000001798 Gadus morhua ENSGMOG00000001798 I 0.756
ENSGMOG00000019585 Gadus morhua ENSGMOG00000019585 I 0.760
ENSLACG00000008525 Latimeria chalumnae ENSLACG00000008525 I 0.758
ZIC3 Loxodonta africana ENSLAFG00000007048 I 0.763
ZIC1 Loxodonta africana ENSLAFG00000030632 I 0.759
ENSLOCG00000003087 Lepisosteus oculatus ENSLOCG00000003087 I 0.821
ENSLOCG00000007706 Lepisosteus oculatus ENSLOCG00000007706 I 0.759
ENSLOCG00000007717 Lepisosteus oculatus ENSLOCG00000007717 I 0.759
ENSMEUG00000004592 Macropus eugenii ENSMEUG00000004592 I 0.825
ENSMEUG00000009632 Macropus eugenii ENSMEUG00000009632 I 0.762
ENSMICG00000010339 Microcebus murinus ENSMICG00000010339 I 0.763
ENSONIG00000002716 Oreochromis niloticus ENSONIG00000002716 I 0.763