PRDM16 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000142611 T094951_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
PRDM16
M10223_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_03		 (Direct) (Direct)
PRDM16
M10224_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_04		 (Direct) (Direct)
PRDM16
M10225_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PRDM16_05		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000270722 C2H2 ZF 230 251
ENSP00000270722 C2H2 ZF 281 303
ENSP00000270722 C2H2 ZF 309 331
ENSP00000270722 C2H2 ZF 337 360
ENSP00000270722 C2H2 ZF 366 388
ENSP00000270722 C2H2 ZF 394 416
ENSP00000270722 C2H2 ZF 423 444
ENSP00000270722 C2H2 ZF 951 973
ENSP00000270722 C2H2 ZF 979 1002
ENSP00000270722 C2H2 ZF 1008 1030
ENSP00000367643 C2H2 ZF 230 251
ENSP00000367643 C2H2 ZF 281 303
ENSP00000367643 C2H2 ZF 309 331
ENSP00000367643 C2H2 ZF 337 360
ENSP00000367643 C2H2 ZF 366 388
ENSP00000367643 C2H2 ZF 394 416
ENSP00000367643 C2H2 ZF 423 444
ENSP00000367643 C2H2 ZF 951 973
ENSP00000367643 C2H2 ZF 979 1002
ENSP00000367643 C2H2 ZF 1008 1030
ENSP00000421400 C2H2 ZF 231 252
ENSP00000421400 C2H2 ZF 282 304
ENSP00000421400 C2H2 ZF 310 332
ENSP00000421400 C2H2 ZF 338 361
ENSP00000421400 C2H2 ZF 367 389
ENSP00000421400 C2H2 ZF 395 417
ENSP00000421400 C2H2 ZF 424 445
ENSP00000421400 C2H2 ZF 951 973
ENSP00000421400 C2H2 ZF 979 1002
ENSP00000421400 C2H2 ZF 1008 1030
ENSP00000425796 C2H2 ZF 39 60
ENSP00000425796 C2H2 ZF 90 112
ENSP00000425796 C2H2 ZF 118 140
ENSP00000425796 C2H2 ZF 146 169
ENSP00000425796 C2H2 ZF 175 197
ENSP00000425796 C2H2 ZF 203 225
ENSP00000425796 C2H2 ZF 232 253
ENSP00000425796 C2H2 ZF 759 781
ENSP00000425796 C2H2 ZF 787 810
ENSP00000425796 C2H2 ZF 816 838
ENSP00000426975 C2H2 ZF 231 252
ENSP00000426975 C2H2 ZF 282 304
ENSP00000426975 C2H2 ZF 310 332
ENSP00000426975 C2H2 ZF 338 361
ENSP00000426975 C2H2 ZF 367 389
ENSP00000426975 C2H2 ZF 395 417
ENSP00000426975 C2H2 ZF 424 445
ENSP00000426975 C2H2 ZF 952 974
ENSP00000426975 C2H2 ZF 980 1003
ENSP00000426975 C2H2 ZF 1009 1031

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

33 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
PRDM16 Gorilla gorilla ENSGGOG00000003763 I 0.827
ENSPPYG00000001968 Pongo abelii ENSPPYG00000001968 I 0.827
PRDM16 Macaca mulatta ENSMMUG00000009350 I 0.827
ENSP00000270722 Macaca fascicularis ENSP00000270722 I 0.827
PRDM16 Loxodonta africana ENSLAFG00000001071 I 0.825
PRDM16 Meleagris gallopavo ENSMGAG00000001857 I 0.825
Afo_R003306 Aptenodytes forsteri Afo_R003306 I 0.825
Alligator_sinensis_CCG011602.1 Alligator sinensis Alligator_sinensis_CCG011602.1 I 0.825
Brh_R007819 Buceros rhinoceros Brh_R007819 I 0.825
ENSGALG00000001063 Gallus gallus ENSGALG00000001063 I 0.825
Gfo_R009744 Geospiza fortis Gfo_R009744 I 0.825
ENSAPLG00000005898 Anas platyrhynchos ENSAPLG00000005898 I 0.825
PRDM16 Bos taurus ENSBTAG00000018965 I 0.824
XP_002938538 Xenopus tropicalis XP_002938538 I 0.824
ENSP00000417899-D2 Bos grunniens ENSP00000417899-D2 I 0.824
ENSPSIG00000004093 Pelodiscus sinensis ENSPSIG00000004093 I 0.823
PRDM16 Otolemur garnettii ENSOGAG00000005055 I 0.823
PRDM16 Equus caballus ENSECAG00000017045 I 0.822
PRDM16 Canis familiaris ENSCAFG00000019473 I 0.819
PRDM16 Sus scrofa ENSSSCG00000021490 I 0.816
ENSLOCG00000005336 Lepisosteus oculatus ENSLOCG00000005336 I 0.809
ENSFALG00000009580 Ficedula albicollis ENSFALG00000009580 I 0.803
Aan_R005955 Calypte anna Aan_R005955 I 0.803
Ogr15306 Ophisaurus gracilis Ogr15306 I 0.800
PRDM16 Danio rerio ENSDARG00000078324 I 0.778
ENSGMOG00000015664 Gadus morhua ENSGMOG00000015664 I 0.777
ENSAMXG00000014024 Astyanax mexicanus ENSAMXG00000014024 I 0.775
ENSPFOG00000010341 Poecilia formosa ENSPFOG00000010341 I 0.772
si:ch211-263k4.2 Gasterosteus aculeatus ENSGACG00000006600 I 0.772
ENSXMAG00000019072 Xiphophorus maculatus ENSXMAG00000019072 I 0.772
si:ch211-263k4.2 Oryzias latipes ENSORLG00000004492 I 0.772
ENSONIG00000002121 Oreochromis niloticus ENSONIG00000002121 I 0.767