PRDM14 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000147596 T094966_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
PRDM14
M08897_2.00
Homo sapiens
NRGGWCYCTAACYH

DRGTTAGRGWCCYN
Misc
Kulakovskiy et al.(2013)
PRD14_HUMAN.H11MO.0.A
(Direct) (Direct)
PRDM14
M09509_2.00
Homo sapiens
RSTTAGRGACCY

RGGTCYCTAASY
Misc
Heinz et al.(2010)
H1-PRDM14_GSE22767
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000276594 C2H2 ZF 400 421
ENSP00000276594 C2H2 ZF 432 455
ENSP00000276594 C2H2 ZF 461 483
ENSP00000276594 C2H2 ZF 489 511
ENSP00000276594 C2H2 ZF 517 540
ENSP00000276594 C2H2 ZF 546 568

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

19 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPANG00000024378 Papio anubis ENSPANG00000024378 I 0.827
ENSPPYG00000018658 Pongo abelii ENSPPYG00000018658 I 0.827
PRDM14 Pan troglodytes ENSPTRG00000020331 I 0.827
ENSP00000276594 Macaca fascicularis ENSP00000276594 I 0.827
ENSMMUG00000014191 Macaca mulatta ENSMMUG00000014191 I 0.827
PRDM14 Gorilla gorilla ENSGGOG00000011363 I 0.827
PRDM14 Callithrix jacchus ENSCJAG00000008052 I 0.827
ENSCSAG00000013856 Chlorocebus sabaeus ENSCSAG00000013856 I 0.827
ENSTSYG00000010610 Tarsius syrichta ENSTSYG00000010610 I 0.790
ENSFCAG00000001436 Felis catus ENSFCAG00000001436 I 0.787
ENSDNOG00000014500 Dasypus novemcinctus ENSDNOG00000014500 I 0.784
ENSMPUG00000010629 Mustela putorius furo ENSMPUG00000010629 I 0.784
PRDM14 Canis familiaris ENSCAFG00000007696 I 0.779
PRDM14 Equus caballus ENSECAG00000014777 I 0.778
ENSAMEG00000006227 Ailuropoda melanoleuca ENSAMEG00000006227 I 0.777
PRDM14 Cavia porcellus ENSCPOG00000027176 I 0.769
PRDM14 Bos taurus ENSBTAG00000000060 I 0.761
ENSOARG00000003528 Ovis aries ENSOARG00000003528 I 0.761
ENSBTAP00000000066-D1 Bos grunniens ENSBTAP00000000066-D1 I 0.761