ZIC1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000152977 T094981_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZIC1
M02893_2.00		 Homo sapiens
KRCCCCCYGCTGYG
CRCAGCRGGGGGYM		 SELEX
Jolma et al.(2013)
ZIC1_1		 (Direct) (Direct)
ZIC1
M04485_2.00		 Homo sapiens
BVCCMCCYGYHGYGH
DCRCDRCRGGKGGBV		 SELEX
Yin et al.(2017)
ZIC1_eDBD_HT-SELEX		 (Direct) (Direct)
ZIC1
M04486_2.00		 Homo sapiens
BACCCCCYRCTGTGM
KCACAGYRGGGGGTV		 SELEX
Yin et al.(2017)
ZIC1_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
ZIC1
M04487_2.00		 Homo sapiens
BVCCCCCYGCTGYGH
DCRCAGCRGGGGGBV		 SELEX
Yin et al.(2017)
ZIC1_FL_HT-SELEX		 (Direct) (Direct)
ZIC1
M04488_2.00		 Homo sapiens
BRCCCCCTGCTGTGH
DCACAGCAGGGGGYV		 SELEX
Yin et al.(2017)
ZIC1_FL_Methyl-HT-SELEX		 (Direct) (Direct)
ZIC1
M08900_2.00		 Homo sapiens
BMSCHCCCM
KGGGDGSKV		 Misc
Kulakovskiy et al.(2013)
ZIC1_HUMAN.H11MO.0.B		 (Direct) (Direct)
ZIC1
M10226_2.00		 Homo sapiens
KRCNMMCYV
BRGKKNGTM		 Transfac
Matys et al.(2006)
V$ZIC1_01		 (Direct) (Direct)
ZIC1
M10227_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZIC1_Q2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zic1
M00137_2.00 		Mus musculus
NCMYVBNGNK
MNCNVBRKGN		 PBM
Badis et al.(2009)
Zic1_0991 		0.827 1.000
Zic1
M08990_2.00 		Mus musculus
BMSCHCCCM
KGGGDGSKV		 Misc
Kulakovskiy et al.(2013)
ZIC1_MOUSE.H11MO.0.B 		0.827 1.000
Zic2
M00150_2.00 		Mus musculus
NCMYVYNRNN
NNYNRBRKGN		 PBM
Badis et al.(2009)
Zic2_2895 		0.804 0.973
ZIC2
M08233_2.00 		Homo sapiens
BBCCTGCWGNB
VNCWGCAGGVV		 ChIP-seq
Najafabadi et al.(2015b)
ZIC2 		0.804 0.973
Zic2
M09011_2.00 		Mus musculus
NRMYHCCTGCTGDGH
DCHCAGCAGGDRKYN		 Misc
Kulakovskiy et al.(2013)
ZIC2_MOUSE.H11MO.0.C 		0.804 0.973
ZIC2
M10107_2.00 		Homo sapiens
VACCMCCCH
DGGGKGGTB		 Transfac
Matys et al.(2006)
V$ZIC2_01 		0.804 0.973
ZIC4
M02912_2.00 		Homo sapiens
KRCCCCCYGYDGNGH
DCNCHRCRGGGGGYM		 SELEX
Jolma et al.(2013)
ZIC4_1 		0.801 0.920
ZIC4
M04566_2.00 		Homo sapiens
BVCMHCMYRYNRYGH
DCRYNRYRKGDKGBV		 SELEX
Yin et al.(2017)
ZIC4_eDBD_HT-SELEX 		0.801 0.920
ZIC4
M04567_2.00 		Homo sapiens
BRCCHCCYRYBGTKH
DMACVRYRGGDGGYV		 SELEX
Yin et al.(2017)
ZIC4_eDBD_Methyl-HT-SELEX 		0.801 0.920
Zic3
M00151_2.00 		Mus musculus
NCMYVBNRNB
VNYNVBRKGN		 PBM
Badis et al.(2009)
Zic3_3119 		0.799 0.920
ZIC3
M02894_2.00 		Homo sapiens
BACCCCCYGCKGYGH
DCRCMGCRGGGGGTV		 SELEX
Jolma et al.(2013)
ZIC3_1 		0.799 0.920
Zic3
M02936_2.00 		Mus musculus
KRCCCCCYGCTGYGH
DCRCAGCRGGGGGYM		 SELEX
Jolma et al.(2013)
Zic3_1 		0.799 0.920
ZIC3
M04491_2.00 		Homo sapiens
VGACCCCCYGCTGTGM
KCACAGCRGGGGGTCB		 SELEX
Yin et al.(2017)
ZIC3_eDBD_HT-SELEX 		0.799 0.920
ZIC3
M04493_2.00 		Homo sapiens
BACCCCCYGCTGYGH
DCRCAGCRGGGGGTV		 SELEX
Yin et al.(2017)
ZIC3_FL_HT-SELEX 		0.799 0.920
ZIC3
M08902_2.00 		Homo sapiens
NVVYHCCTGCTGDGN
NCHCAGCAGGDRBBN		 Misc
Kulakovskiy et al.(2013)
ZIC3_HUMAN.H11MO.0.B 		0.799 0.920
Zic3
M09013_2.00 		Mus musculus
NVVYHCCTGCTGDGN
NCHCAGCAGGDRBBN		 Misc
Kulakovskiy et al.(2013)
ZIC3_MOUSE.H11MO.0.A 		0.799 0.920
ZIC3
M10229_2.00 		Homo sapiens
VRBCMCCCN
NGGGKGVYB		 Transfac
Matys et al.(2006)
V$ZIC3_01 		0.799 0.920
Zic3
M10359_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZIC3_07 		0.799 0.920
ZIC3
M04492_2.00 		Homo sapiens
NKACCCCCTGCTGTGM
KCACAGCAGGGGGTMN		 SELEX
Yin et al.(2017)
ZIC3_eDBD_Methyl-HT-SELEX 		0.799 0.920
ZIC3
M04494_2.00 		Homo sapiens
BRCCCCCTGCTGTGM
KCACAGCAGGGGGYV		 SELEX
Yin et al.(2017)
ZIC3_FL_Methyl-HT-SELEX 		0.799 0.920
Zic5
M00780_2.00 		Mus musculus
BRCCCCCYDS
SHRGGGGGYV		 PBM
Weirauch et al.(2013)
pTH2818 		0.769 0.893
ZIC5
M04471_2.00 		Homo sapiens
NKACCCCCCGCTGHGH
DCDCAGCGGGGGGTMN		 SELEX
Yin et al.(2017)
ZIC5_eDBD_HT-SELEX 		0.759 0.884
ZIC5
M04472_2.00 		Homo sapiens
NKACCCCCYGCTGTGM
KCACAGCRGGGGGTMN		 SELEX
Yin et al.(2017)
ZIC5_eDBD_Methyl-HT-SELEX 		0.759 0.884
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000282928 C2H2 ZF 240 260
ENSP00000282928 C2H2 ZF 269 296
ENSP00000282928 C2H2 ZF 302 326
ENSP00000282928 C2H2 ZF 332 356
ENSP00000282928 C2H2 ZF 362 384
ENSP00000419664 C2H2 ZF 21 45
ENSP00000419664 C2H2 ZF 51 73

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

302 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action