ZBTB7B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000160685 T095006_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZBTB7B
M02895_2.00		 Homo sapiens
DCGACCMCCVAN
NTBGGKGGTCGH		 SELEX
Jolma et al.(2013)
ZBTB7B_1		 (Direct) (Direct)
ZBTB7B
M04497_2.00		 Homo sapiens
DCGACCACCN
NGGTGGTCGH		 SELEX
Yin et al.(2017)
ZBTB7B_eDBD_HT-SELEX		 (Direct) (Direct)
ZBTB7B
M04498_2.00		 Homo sapiens
DCGMCCACCN
NGGTGGKCGH		 SELEX
Yin et al.(2017)
ZBTB7B_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
ZBTB7B
M10233_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CKROX_Q2		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zbtb7b
M00135_2.00 		Mus musculus
NKMCCCCNNN
NNNGGGGKMN		 PBM
Badis et al.(2009)
Zbtb7b_1054 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000292176 C2H2 ZF 346 368
ENSP00000292176 C2H2 ZF 374 396
ENSP00000292176 C2H2 ZF 402 424
ENSP00000292176 C2H2 ZF 430 451
ENSP00000357411 C2H2 ZF 346 368
ENSP00000357411 C2H2 ZF 374 396
ENSP00000357411 C2H2 ZF 402 424
ENSP00000357411 C2H2 ZF 430 451
ENSP00000406286 C2H2 ZF 380 402
ENSP00000406286 C2H2 ZF 408 430
ENSP00000406286 C2H2 ZF 436 458
ENSP00000406286 C2H2 ZF 464 485
ENSP00000438647 C2H2 ZF 346 368
ENSP00000438647 C2H2 ZF 374 396
ENSP00000438647 C2H2 ZF 402 424
ENSP00000438647 C2H2 ZF 430 451

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

Invalid Input OrderBy

42 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action