TF Information

ZNF281 *(Homo sapiens)* C2H2 ZF
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00096 (zf-C2H2)	IPR007087	ENSG00000162702	T095017_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
ZNF281 M04509_2.00	Homo sapiens	SCCCCTCCCCCM	KGGGGGAGGGGS	SELEX Yin et al.(2017) ZNF281_eDBD_HT-SELEX	(Direct)	(Direct)
ZNF281 M04510_2.00	Homo sapiens	RCCCMTCCCCCR	YGGGGGAKGGGY	SELEX Yin et al.(2017) ZNF281_eDBD_Methyl-HT-SELEX	(Direct)	(Direct)
ZNF281 M08321_2.00	Homo sapiens	BNCCCCTCCCCC	GGGGGAGGGGNV	ChIP-seq Schmitges et al.(2016) Q9Y2X9_1-4.RCADE	(Direct)	(Direct)
ZNF281 M08906_2.00	Homo sapiens	BCCCCTCCCCCHNYN	NRNDGGGGGAGGGGV	Misc Kulakovskiy et al.(2013) ZN281_HUMAN.H11MO.0.A	(Direct)	(Direct)
ZNF281 M10237_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$ZFP281_01	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Zfp281 M00139_2.00	Mus musculus	NHDCCCCCHH	DDGGGGGHDN	PBM Badis et al.(2009) Zfp281_0973	0.827	1.000
Zfp281 M08025_2.00	Mus musculus	CCCCWCCCCCMVCHB	VDGBKGGGGGWGGGG	ChIP-seq Chen et al.(2011) GSE11329_zfp281	0.827	1.000
Zfp281 M08999_2.00	Mus musculus	CCCCTCCCCCMMCBB	VVGKKGGGGGAGGGG	Misc Kulakovskiy et al.(2013) ZN281_MOUSE.H11MO.0.A	0.827	1.000
For this family, TFs with SR scores > 0.755* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSP00000294740	C2H2 ZF	261	283	HICDHCSAAFRSSYHLRRHVLIH
ENSP00000294740	C2H2 ZF	289	311	FQCSQCSMGFIQKYLLQRHEKIH
ENSP00000294740	C2H2 ZF	317	339	FGCDQCSMKFIQKYHMERHKRTH
ENSP00000294740	C2H2 ZF	345	366	YKCDTCQQYFSRTDRLLKHRRT
ENSP00000356321	C2H2 ZF	225	247	HICDHCSAAFRSSYHLRRHVLIH
ENSP00000356321	C2H2 ZF	253	275	FQCSQCSMGFIQKYLLQRHEKIH
ENSP00000356321	C2H2 ZF	281	303	FGCDQCSMKFIQKYHMERHKRTH
ENSP00000356321	C2H2 ZF	309	330	YKCDTCQQYFSRTDRLLKHRRT
ENSP00000356322	C2H2 ZF	261	283	HICDHCSAAFRSSYHLRRHVLIH
ENSP00000356322	C2H2 ZF	289	311	FQCSQCSMGFIQKYLLQRHEKIH
ENSP00000356322	C2H2 ZF	317	339	FGCDQCSMKFIQKYHMERHKRTH
ENSP00000356322	C2H2 ZF	345	366	YKCDTCQQYFSRTDRLLKHRRT

Links
Other C2H2 ZF family TFs
Other *Homo sapiens* TFs

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67 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action