GFI1B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000165702 T095034_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GFI1B
M00239_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_A204T
(Direct) (Direct)
GFI1B
M00240_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_REF
(Direct) (Direct)
GFI1B
M04523_2.00
Homo sapiens
NMAATCASDGCNNBBCACTNN

NNAGTGVVNNGCHSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_HT-SELEX
(Direct) (Direct)
GFI1B
M04524_2.00
Homo sapiens
NMAATCASWGCDNNBCACTHN

NDAGTGVNNHGCWSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
GFI1B
M08909_2.00
Homo sapiens
MAATCWSDGY

RCHSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1B_HUMAN.H11MO.0.A
(Direct) (Direct)
GFI1B
M10243_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_01
(Direct) (Direct)
GFI1B
M10244_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
sens
M03666_2.00
Drosophila melanogaster
TGCWSTGATTTATY

RATAAATCASWGCA
SELEX
Nitta et al.(2015)
sens_1
0.789 0.859
sens
M06056_2.00
Drosophila melanogaster
AAATCACDGC

GCHGTGATTT
B1H
Zhu et al.(2011)
sens_SANGER_10_FBgn0002573
0.789 0.859
sens
M06057_2.00
Drosophila melanogaster
NNNNAAATCACRGCH

DGCYGTGATTTNNNN
B1H
Zhu et al.(2011)
sens_SOLEXA_5_FBgn0002573
0.789 0.859
Gfi1b
M08098_2.00
Mus musculus
MAATCWCWGCH

DGCWGWGATTK
ChIP-seq
Mathelier et al.(2014)
MA0483.1
0.825 0.993
Gfi1b
M08977_2.00
Mus musculus
MAAYCACWGH

DCWGWGRTTK
Misc
Kulakovskiy et al.(2013)
GFI1B_MOUSE.H11MO.0.A
0.825 0.993
Gfi1b
M09514_2.00
Mus musculus
MAATCWSWGC

GCWSWGATTK
Misc
Heinz et al.(2010)
HPC7-Gfi1b_GSE22178
0.825 0.993
sens-2
M06165_2.00
Drosophila melanogaster
RYAAATCWSDGCAYNC

GNRTGCHSWGATTTRY
B1H
Zhu et al.(2011)
sens-2_SANGER_2.5_FBgn0051632
0.782 0.833
GFI1
M00238_2.00
Homo sapiens
NWAWMNNNN

NNNNKWTWN
PBM
Barrera et al.(2016)
GFI1_REF
0.781 0.877
GFI1
M04507_2.00
Homo sapiens
BMAATCACDGCNHBBCACTMN

NKAGTGVVDNGCHGTGATTKV
SELEX
Yin et al.(2017)
GFI1_eDBD_HT-SELEX
0.781 0.877
Gfi1
M02668_2.00
Rattus norvegicus
NMAATCWVHS

SDBWGATTKN
SELEX
Mathelier et al.(2014)
MA0038.1
0.781 0.877
GFI1
M08905_2.00
Homo sapiens
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_HUMAN.H11MO.0.C
0.781 0.877
Gfi1
M08984_2.00
Mus musculus
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_MOUSE.H11MO.0.C
0.781 0.877
GFI1
M10235_2.00
Homo sapiens
NNNNNNNRCHSWGATTTDNNBNNN

NNNVNNHAAATCWSDGYNNNNNNN
Transfac
Matys et al.(2006)
V$GFI1_01
0.781 0.877
GFI1
M10236_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1_Q6_01
0.781 0.877
GFI1
M04508_2.00
Homo sapiens
NNAGTGVVNHGCWSTGATTKV

BMAATCASWGCDNBBCACTNN
SELEX
Yin et al.(2017)
GFI1_eDBD_Methyl-HT-SELEX
0.781 0.877
GFI1
M00236_2.00
Homo sapiens
NAATMNNNN

NNNNKATTN
PBM
Barrera et al.(2016)
GFI1_L400F
0.779 0.870
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00239_2.00 C2H2 ZF 6 29
M00239_2.00 C2H2 ZF 35 57
M00239_2.00 C2H2 ZF 63 85
M00239_2.00 C2H2 ZF 91 113
M00239_2.00 C2H2 ZF 119 141
M00239_2.00 C2H2 ZF 147 170
M00240_2.00 C2H2 ZF 6 29
M00240_2.00 C2H2 ZF 35 57
M00240_2.00 C2H2 ZF 63 85
M00240_2.00 C2H2 ZF 91 113
M00240_2.00 C2H2 ZF 119 141
M00240_2.00 C2H2 ZF 147 170

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000344782 C2H2 ZF 163 186
ENSP00000344782 C2H2 ZF 192 214
ENSP00000344782 C2H2 ZF 220 242
ENSP00000344782 C2H2 ZF 248 270
ENSP00000344782 C2H2 ZF 276 298
ENSP00000344782 C2H2 ZF 304 327
ENSP00000361195 C2H2 ZF 163 186
ENSP00000361195 C2H2 ZF 192 214
ENSP00000361195 C2H2 ZF 220 242
ENSP00000361195 C2H2 ZF 248 270
ENSP00000361195 C2H2 ZF 276 298
ENSP00000361195 C2H2 ZF 304 327
ENSP00000361196 C2H2 ZF 174 196
ENSP00000361196 C2H2 ZF 202 224
ENSP00000361196 C2H2 ZF 230 252
ENSP00000361196 C2H2 ZF 258 281

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

196 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
PMAA_029710 Penicillium marneffei PMAA_029710 N 0.000
PV08_06011 Exophiala spinifera PV08_06011 N 0.000
PV07_10166 Cladophialophora immunda PV07_10166 N 0.000
PV06_03594 Exophiala oligosperma PV06_03594 N 0.000
PV05_11133 Exophiala xenobiotica PV05_11133 N 0.000
PV04_01563 Capronia semiimmersa PV04_01563 N 0.000
PMAA_029710 Talaromyces marneffei PMAA_029710 N 0.000
PABG_01676 Paracoccidioides brasiliensis PABG_01676 N 0.000
PAAG_11207 Paracoccidioides sp lutzii PAAG_11207 N 0.000
Mycgr3G49868 Zymoseptoria tritici Mycgr3G49868 N 0.000
MYCFIDRAFT_115419 Pseudocercospora fijiensis MYCFIDRAFT_115419 N 0.000
PV10_07538 Exophiala mesophila PV10_07538 N 0.000
PV11_08024 Exophiala sideris PV11_08024 N 0.000
SPBR_04611 Sporothrix brasiliensis SPBR_04611 N 0.000
gw1.6.17.1 Mycosphaerella fijiensis gw1.6.17.1 N 0.000
e_gw1.11.76.1 Mycosphaerella graminicola e_gw1.11.76.1 N 0.000
Z519_03005 Cladophialophora bantiana Z519_03005 N 0.000
Z518_04016 Rhinocladiella mackenziei Z518_04016 N 0.000
Z517_08280 Fonsecaea pedrosoi Z517_08280 N 0.000
W97_06158 Coniosporium apollinis W97_06158 N 0.000
UREG_01015 Uncinocarpus reesii UREG_01015 N 0.000
TSTA_068680 Talaromyces stipitatus TSTA_068680 N 0.000
TRV_06300 Trichophyton verrucosum TRV_06300 N 0.000
TEQG_02005 Trichophyton equinum TEQG_02005 N 0.000
MGYG_02110 Microsporum gypseum MGYG_02110 N 0.000
MCYG_04527 Arthroderma otae MCYG_04527 N 0.000
MBM_04902 Marssonina brunnea MBM_04902 N 0.000
COCSADRAFT_109777 Bipolaris sorokiniana COCSADRAFT_109777 N 0.000
COCCADRAFT_35218 Bipolaris zeicola COCCADRAFT_35218 N 0.000
CADAFLAG00009321 Aspergillus flavus CADAFLAG00009321 N 0.000
BDDG_00723 Blastomyces dermatitidis BDDG_00723 N 0.000
ARB_04972 Arthroderma benhamiae ARB_04972 N 0.000
A1O9_04841 Exophiala aquamarina A1O9_04841 N 0.000
A1O7_00496 Cladophialophora yegresii A1O7_00496 N 0.000
A1O5_03686 Cladophialophora psammophila A1O5_03686 N 0.000
A1O1_00584 Capronia coronata A1O1_00584 N 0.000
MCYG_04527 Microsporum canis MCYG_04527 N 0.000
CPC735_052920 Coccidioides posadasii CPC735_052920 N 0.000
DOTSEDRAFT_74979 Dothistroma septosporum DOTSEDRAFT_74979 N 0.000
EPUS_07706 Endocarpon pusillum EPUS_07706 N 0.000
HMPREF1624_05208 Sporothrix schenckii HMPREF1624_05208 N 0.000
HMPREF1541_08216 Cyphellophora europaea HMPREF1541_08216 N 0.000
HMPREF1541_05902 Cyphellophora europaea HMPREF1541_05902 N 0.000
HMPREF1120_06189 Exophiala dermatitidis HMPREF1120_06189 N 0.000
HCBG_00932 Histoplasma capsulatum HCBG_00932 N 0.000
H105_05671 Trichophyton soudanense H105_05671 N 0.000
H102_05631 Trichophyton rubrum H102_05631 N 0.000
H101_00145 Trichophyton interdigitale H101_00145 N 0.000
G647_00537 Cladophialophora carrionii G647_00537 N 0.000
F503_04816 Ophiostoma piceae uamh F503_04816 N 0.000
CIMG_01069 Coccidioides immitis CIMG_01069 N 0.000