GFI1B (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000165702 T095034_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GFI1B
M00239_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_A204T
(Direct) (Direct)
GFI1B
M00240_2.00
Homo sapiens
NNAAATCWSDN

NHSWGATTTNN
PBM
Barrera et al.(2016)
GFI1B_REF
(Direct) (Direct)
GFI1B
M04523_2.00
Homo sapiens
NMAATCASDGCNNBBCACTNN

NNAGTGVVNNGCHSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_HT-SELEX
(Direct) (Direct)
GFI1B
M04524_2.00
Homo sapiens
NMAATCASWGCDNNBCACTHN

NDAGTGVNNHGCWSTGATTKN
SELEX
Yin et al.(2017)
GFI1B_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
GFI1B
M08909_2.00
Homo sapiens
MAATCWSDGY

RCHSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1B_HUMAN.H11MO.0.A
(Direct) (Direct)
GFI1B
M10243_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_01
(Direct) (Direct)
GFI1B
M10244_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1B_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
sens
M03666_2.00
Drosophila melanogaster
TGCWSTGATTTATY

RATAAATCASWGCA
SELEX
Nitta et al.(2015)
sens_1
0.789 0.859
sens
M06056_2.00
Drosophila melanogaster
AAATCACDGC

GCHGTGATTT
B1H
Zhu et al.(2011)
sens_SANGER_10_FBgn0002573
0.789 0.859
sens
M06057_2.00
Drosophila melanogaster
NNNNAAATCACRGCH

DGCYGTGATTTNNNN
B1H
Zhu et al.(2011)
sens_SOLEXA_5_FBgn0002573
0.789 0.859
Gfi1b
M08098_2.00
Mus musculus
MAATCWCWGCH

DGCWGWGATTK
ChIP-seq
Mathelier et al.(2014)
MA0483.1
0.825 0.993
Gfi1b
M08977_2.00
Mus musculus
MAAYCACWGH

DCWGWGRTTK
Misc
Kulakovskiy et al.(2013)
GFI1B_MOUSE.H11MO.0.A
0.825 0.993
Gfi1b
M09514_2.00
Mus musculus
MAATCWSWGC

GCWSWGATTK
Misc
Heinz et al.(2010)
HPC7-Gfi1b_GSE22178
0.825 0.993
sens-2
M06165_2.00
Drosophila melanogaster
RYAAATCWSDGCAYNC

GNRTGCHSWGATTTRY
B1H
Zhu et al.(2011)
sens-2_SANGER_2.5_FBgn0051632
0.782 0.833
GFI1
M00238_2.00
Homo sapiens
NWAWMNNNN

NNNNKWTWN
PBM
Barrera et al.(2016)
GFI1_REF
0.781 0.877
GFI1
M04507_2.00
Homo sapiens
BMAATCACDGCNHBBCACTMN

NKAGTGVVDNGCHGTGATTKV
SELEX
Yin et al.(2017)
GFI1_eDBD_HT-SELEX
0.781 0.877
Gfi1
M02668_2.00
Rattus norvegicus
NMAATCWVHS

SDBWGATTKN
SELEX
Mathelier et al.(2014)
MA0038.1
0.781 0.877
GFI1
M08905_2.00
Homo sapiens
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_HUMAN.H11MO.0.C
0.781 0.877
Gfi1
M08984_2.00
Mus musculus
MAATCWSWGY

RCWSWGATTK
Misc
Kulakovskiy et al.(2013)
GFI1_MOUSE.H11MO.0.C
0.781 0.877
GFI1
M10235_2.00
Homo sapiens
NNNNNNNRCHSWGATTTDNNBNNN

NNNVNNHAAATCWSDGYNNNNNNN
Transfac
Matys et al.(2006)
V$GFI1_01
0.781 0.877
GFI1
M10236_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$GFI1_Q6_01
0.781 0.877
GFI1
M04508_2.00
Homo sapiens
NNAGTGVVNHGCWSTGATTKV

BMAATCASWGCDNBBCACTNN
SELEX
Yin et al.(2017)
GFI1_eDBD_Methyl-HT-SELEX
0.781 0.877
GFI1
M00236_2.00
Homo sapiens
NAATMNNNN

NNNNKATTN
PBM
Barrera et al.(2016)
GFI1_L400F
0.779 0.870
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00239_2.00 C2H2 ZF 6 29
M00239_2.00 C2H2 ZF 35 57
M00239_2.00 C2H2 ZF 63 85
M00239_2.00 C2H2 ZF 91 113
M00239_2.00 C2H2 ZF 119 141
M00239_2.00 C2H2 ZF 147 170
M00240_2.00 C2H2 ZF 6 29
M00240_2.00 C2H2 ZF 35 57
M00240_2.00 C2H2 ZF 63 85
M00240_2.00 C2H2 ZF 91 113
M00240_2.00 C2H2 ZF 119 141
M00240_2.00 C2H2 ZF 147 170

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000344782 C2H2 ZF 163 186
ENSP00000344782 C2H2 ZF 192 214
ENSP00000344782 C2H2 ZF 220 242
ENSP00000344782 C2H2 ZF 248 270
ENSP00000344782 C2H2 ZF 276 298
ENSP00000344782 C2H2 ZF 304 327
ENSP00000361195 C2H2 ZF 163 186
ENSP00000361195 C2H2 ZF 192 214
ENSP00000361195 C2H2 ZF 220 242
ENSP00000361195 C2H2 ZF 248 270
ENSP00000361195 C2H2 ZF 276 298
ENSP00000361195 C2H2 ZF 304 327
ENSP00000361196 C2H2 ZF 174 196
ENSP00000361196 C2H2 ZF 202 224
ENSP00000361196 C2H2 ZF 230 252
ENSP00000361196 C2H2 ZF 258 281

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

196 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
sens-2 Drosophila melanogaster FBgn0051632 D 0.782
GFI1 Homo sapiens ENSG00000162676 D 0.781
Gfi1b Mus musculus ENSMUSG00000026815 D 0.825
Gfi1 Mus musculus ENSMUSG00000029275 D 0.781
Gfi1 Rattus norvegicus ENSRNOG00000002042 D 0.781
sens Drosophila melanogaster FBgn0002573 D 0.789
HelroG145685 Helobdella robusta HelroG145685 I 0.781
HelroG67579 Helobdella robusta HelroG67579 I 0.757
HelroG145534 Helobdella robusta HelroG145534 I 0.767
GB48486 Apis mellifera GB48486 I 0.785
GA28112 Drosophila pseudoobscura FBgn0249475 I 0.789
GE20069 Drosophila yakuba FBgn0237393 I 0.789
HMEL012459 Heliconius melpomene HMEL012459 I 0.801
KGM_22443 Danaus plexippus KGM_22443 I 0.801
L798_01833 Zootermopsis nevadensis L798_01833 I 0.795
tetur16g01570 Tetranychus urticae tetur16g01570 I 0.773
TC013474 Tribolium castaneum TC013474 I 0.792
SPU_012645 Strongylocentrotus purpuratus SPU_012645 I 0.783
PHUM248190 Pediculus humanus PHUM248190 I 0.797
NV16026 Nasonia vitripennis NV16026 I 0.785
NEMVEDRAFT_v1g182742 Nematostella vectensis NEMVEDRAFT_v1g182742 I 0.766
MESCA000812 Megaselia scalaris MESCA000812 I 0.798
LotgiG98465 Lottia gigantea LotgiG98465 I 0.783
LotgiG83709 Lottia gigantea LotgiG83709 I 0.773
LotgiG129344 Lottia gigantea LotgiG129344 I 0.771
GE14143 Drosophila yakuba FBgn0231766 I 0.782
GK24242 Drosophila willistoni FBgn0226203 I 0.782
GG13774 Drosophila erecta FBgn0106037 I 0.789
GG10437 Drosophila erecta FBgn0102746 I 0.782
GF15430 Drosophila ananassae FBgn0092455 I 0.782
GF10411 Drosophila ananassae FBgn0087452 I 0.789
GA16696 Drosophila pseudoobscura FBgn0076711 I 0.789
GA16348 Drosophila pseudoobscura FBgn0076363 I 0.782
gfi1ab Takifugu rubripes ENSTRUG00000000415 I 0.784
ENSXMAG00000009274 Xiphophorus maculatus ENSXMAG00000009274 I 0.768
GFI1 Tursiops truncatus ENSTTRG00000000082 I 0.783
gfi1aa Takifugu rubripes ENSTRUG00000004744 I 0.768
GH13715 Drosophila grimshawi FBgn0121191 I 0.782
GH16734 Drosophila grimshawi FBgn0124205 I 0.789
GK12454 Drosophila willistoni FBgn0214464 I 0.789
GJ21268 Drosophila virilis FBgn0208401 I 0.782
GJ11823 Drosophila virilis FBgn0199077 I 0.789
GD12667 Drosophila simulans FBgn0184394 I 0.789
GM24598 Drosophila sechellia FBgn0179461 I 0.789
GM16223 Drosophila sechellia FBgn0171139 I 0.782
GL26188 Drosophila persimilis FBgn0163770 I 0.782
GL15695 Drosophila persimilis FBgn0153299 I 0.789
GI23984 Drosophila mojavensis FBgn0146708 I 0.782
GI13460 Drosophila mojavensis FBgn0136216 I 0.789
gfi1b Takifugu rubripes ENSTRUG00000004525 I 0.804
SVE_0901200 Strongyloides venezuelensis SVE_0901200 I 0.791
MDOA011065 Musca domestica MDOA011065 I 0.782
MDOA006012 Musca domestica MDOA006012 I 0.779
LLOJ009104 Lutzomyia longipalpis LLOJ009104 I 0.801
ASTEI06414 Anopheles stephensi ASTEI06414 I 0.797
AMEM009379 Anopheles merus AMEM009379 I 0.797
AMEC011115 Anopheles melas AMEC011115 I 0.797
AFAF000823 Anopheles farauti AFAF000823 I 0.797
ADIR005637 Anopheles dirus ADIR005637 I 0.797
ACOM022805 Anopheles coluzzii ACOM022805 I 0.797
AATE011452 Anopheles atroparvus AATE011452 I 0.797
ACAC_0000515301 Angiostrongylus cantonensis ACAC_0000515301 I 0.791
BXY_1436800 Bursaphelenchus xylophilus BXY_1436800 I 0.793
SSTP_0000165900 Strongyloides stercoralis SSTP_0000165900 I 0.791
SSLN_0000272801 Schistocephalus solidus SSLN_0000272801 I 0.788
SPAL_0000614400 Strongyloides papillosus SPAL_0000614400 I 0.791
RSKR_0000656700 Rhabditophanes kr3021 RSKR_0000656700 I 0.791
PXEA_0001261301 Protopolystoma xenopodis PXEA_0001261301 I 0.790
PTRK_0000195600 Parastrongyloides trichosuri PTRK_0000195600 I 0.791
nAv.1.0.1.g05276 Acanthocheilonema viteae nAv.1.0.1.g05276 I 0.807
MhA1_Contig1061.frz3.gene12 Meloidogyne hapla MhA1_Contig1061.frz3.gene12 I 0.791
HCOI00212900 Haemonchus contortus HCOI00212900 I 0.781
DILT_0000061901 Diphyllobothrium latum DILT_0000061901 I 0.788
gfi1 Xenopus tropicalis XB-GENE-960553 I 0.781
gfi1b.L Xenopus laevis XB-GENE-944429 I 0.798
gfi1b Xenopus tropicalis XB-GENE-944426 I 0.798
ENSBTAP00000022231-D1 Bos grunniens ENSBTAP00000022231-D1 I 0.779
ENSBTAP00000016974-D1 Bos grunniens ENSBTAP00000016974-D1 I 0.812
Cmyd_10017172 Chelonia mydas Cmyd_10017172 I 0.815
Cmyd_10004881 Chelonia mydas Cmyd_10004881 I 0.782
Cflo_04170--XP_001120914.1_APIME Camponotus floridanus Cflo_04170--XP_001120914.1_APIME I 0.780
Brh_R002465 Buceros rhinoceros Brh_R002465 I 0.784
Alligator_sinensis_CCG007476.1 Alligator sinensis Alligator_sinensis_CCG007476.1 I 0.784
Afo_R006147 Aptenodytes forsteri Afo_R006147 I 0.784
Afo_R001655 Aptenodytes forsteri Afo_R001655 I 0.810
Aan_R008865 Calypte anna Aan_R008865 I 0.810
ENSP00000361195 Macaca fascicularis ENSP00000361195 I 0.825
ENSP00000399719 Macaca fascicularis ENSP00000399719 I 0.777
LCUP007432 Lucilia cuprina LCUP007432 I 0.789
Sakowv30015313m.g Saccoglossus kowalevskii Sakowv30015313m.g I 0.770
e_gw.11.853.1 Branchiostoma floridae e_gw.11.853.1 I 0.772
Tal_R006464 Tyto alba Tal_R006464 I 0.784
Tal_R001363 Tyto alba Tal_R001363 I 0.810
Pvit_00259 Pogona vitticeps Pvit_00259 I 0.782
Ogr09401 Ophisaurus gracilis Ogr09401 I 0.782
Myotis_brandtii_GFI1B_10010118 Myotis brandtii Myotis_brandtii_GFI1B_10010118 I 0.797
Gfo_R010648 Geospiza fortis Gfo_R010648 I 0.784
Gfo_R007994 Geospiza fortis Gfo_R007994 I 0.810
Aan_R000889 Calypte anna Aan_R000889 I 0.784
gfi1b Tetraodon nigroviridis ENSTNIG00000003834 I 0.783
ENSLACG00000012207 Latimeria chalumnae ENSLACG00000012207 I 0.814
ENSFALG00000001479 Ficedula albicollis ENSFALG00000001479 I 0.810
GFI1 Erinaceus europaeus ENSEEUG00000000198 I 0.781
GFI1B Equus caballus ENSECAG00000008127 I 0.823
GFI1 Equus caballus ENSECAG00000006647 I 0.783
Gfi1b Dipodomys ordii ENSDORG00000000342 I 0.817
GFI1B Dasypus novemcinctus ENSDNOG00000036528 I 0.823
GFI1 Dasypus novemcinctus ENSDNOG00000000782 I 0.781
gfi1b Danio rerio ENSDARG00000079947 I 0.797
gfi1ab Danio rerio ENSDARG00000044457 I 0.784
GFI1 Felis catus ENSFCAG00000005914 I 0.781
GFI1B Felis catus ENSFCAG00000027147 I 0.825
gfi1ab Gasterosteus aculeatus ENSGACG00000004257 I 0.773
ENSGMOG00000019123 Gadus morhua ENSGMOG00000019123 I 0.795
ENSGMOG00000017295 Gadus morhua ENSGMOG00000017295 I 0.766
ENSGMOG00000007737 Gadus morhua ENSGMOG00000007737 I 0.784
GFI1B Gorilla gorilla ENSGGOG00000015828 I 0.827
GFI1 Gorilla gorilla ENSGGOG00000005320 I 0.781
ENSGALG00000005940 Gallus gallus ENSGALG00000005940 I 0.784
GFI1B Gallus gallus ENSGALG00000003478 I 0.810
gfi1b Gasterosteus aculeatus ENSGACG00000018134 I 0.795
gfi1aa Gasterosteus aculeatus ENSGACG00000015674 I 0.775
gfi1aa Danio rerio ENSDARG00000020746 I 0.783
ENSCSAG00000015008 Chlorocebus sabaeus ENSCSAG00000015008 I 0.825
GFI1B Cavia porcellus ENSCPOG00000026928 I 0.814
GFI1 Anolis carolinensis ENSACAG00000004498 I 0.782
CGI_10017941 Crassostrea gigas CGI_10017941 I 0.771
CGI_10011355 Crassostrea gigas CGI_10011355 I 0.781
CGI_10001094 Crassostrea gigas CGI_10001094 I 0.766
CapteG45287 Capitella teleta CapteG45287 I 0.757
Bm9493 Brugia malayi Bm9493 I 0.803
BGIBMGA003190 Bombyx mori BGIBMGA003190 I 0.797
AGAP010926 Anopheles gambiae AGAP010926 I 0.797
AAEL000869 Aedes aegypti AAEL000869 I 0.797
ENSAMEG00000013858 Ailuropoda melanoleuca ENSAMEG00000013858 I 0.781
ENSAMXG00000004835 Astyanax mexicanus ENSAMXG00000004835 I 0.786
ENSAMXG00000016347 Astyanax mexicanus ENSAMXG00000016347 I 0.792
GFI1 Cavia porcellus ENSCPOG00000011727 I 0.781
GFI1B Callithrix jacchus ENSCJAG00000018071 I 0.827
GFI1 Callithrix jacchus ENSCJAG00000017609 I 0.781
GFI1 Canis familiaris ENSCAFG00000020155 I 0.781
GFI1B Canis familiaris ENSCAFG00000019877 I 0.823
GFI1 Bos taurus ENSBTAG00000016723 I 0.783
GFI1B Bos taurus ENSBTAG00000012772 I 0.812
ENSAPLG00000015700 Anas platyrhynchos ENSAPLG00000015700 I 0.784
ENSAPLG00000003373 Anas platyrhynchos ENSAPLG00000003373 I 0.810
WUBG_13248 Wuchereria bancrofti WUBG_13248 I 0.803
ENSLACG00000013362 Latimeria chalumnae ENSLACG00000013362 I 0.783
gfi1ab Tetraodon nigroviridis ENSTNIG00000000651 I 0.784
ENSPFOG00000023214 Poecilia formosa ENSPFOG00000023214 I 0.786
ENSPFOG00000017327 Poecilia formosa ENSPFOG00000017327 I 0.768
ENSPFOG00000003460 Poecilia formosa ENSPFOG00000003460 I 0.777
GFI1B Procavia capensis ENSPCAG00000012329 I 0.817
GFI1 Procavia capensis ENSPCAG00000011020 I 0.782
ENSPANG00000024216 Papio anubis ENSPANG00000024216 I 0.825
ENSPANG00000016433 Papio anubis ENSPANG00000016433 I 0.781
gfi1b Oryzias latipes ENSORLG00000014390 I 0.787
gfi1aa Oryzias latipes ENSORLG00000005060 I 0.768
ENSPPYG00000019718 Pongo abelii ENSPPYG00000019718 I 0.827
ENSPSIG00000008734 Pelodiscus sinensis ENSPSIG00000008734 I 0.784
ENSPSIG00000012112 Pelodiscus sinensis ENSPSIG00000012112 I 0.818
GFI1 Taeniopygia guttata ENSTGUG00000006060 I 0.784
ENSSTOG00000022285 Ictidomys tridecemlineatus ENSSTOG00000022285 I 0.822
ENSSTOG00000014583 Ictidomys tridecemlineatus ENSSTOG00000014583 I 0.781
GFI1 Sus scrofa ENSSSCG00000006902 I 0.783
GFI1B Sus scrofa ENSSSCG00000005737 I 0.825
Gfi1b Rattus norvegicus ENSRNOG00000011353 I 0.827
GFI1 Pteropus vampyrus ENSPVAG00000006928 I 0.783
GFI1B Pan troglodytes ENSPTRG00000021505 I 0.827
ENSPTRG00000000961 Pan troglodytes ENSPTRG00000000961 I 0.782
GFI1 Ochotona princeps ENSOPRG00000001473 I 0.781
GFI1B Ochotona princeps ENSOPRG00000000125 I 0.827
ENSONIG00000019246 Oreochromis niloticus ENSONIG00000019246 I 0.784
GFI1B Macaca mulatta ENSMMUG00000005948 I 0.827
ENSMMUG00000005068 Macaca mulatta ENSMMUG00000005068 I 0.781
GFI1 Myotis lucifugus ENSMLUG00000015191 I 0.783
GFI1B Myotis lucifugus ENSMLUG00000006673 I 0.810
GFI1 Meleagris gallopavo ENSMGAG00000008187 I 0.784
GFI1B Meleagris gallopavo ENSMGAG00000006129 I 0.810
ENSLOCG00000005750 Lepisosteus oculatus ENSLOCG00000005750 I 0.797
ENSLOCG00000004711 Lepisosteus oculatus ENSLOCG00000004711 I 0.786
GFI1B Loxodonta africana ENSLAFG00000022367 I 0.811
GFI1 Monodelphis domestica ENSMODG00000011802 I 0.781
GFI1B Monodelphis domestica ENSMODG00000012600 I 0.819
ENSMPUG00000004178 Mustela putorius furo ENSMPUG00000004178 I 0.781
ENSONIG00000013011 Oreochromis niloticus ENSONIG00000013011 I 0.785
ENSONIG00000010573 Oreochromis niloticus ENSONIG00000010573 I 0.768
GFI1 Otolemur garnettii ENSOGAG00000027913 I 0.781
GFI1B Otolemur garnettii ENSOGAG00000008879 I 0.817
GFI1B Oryctolagus cuniculus ENSOCUG00000001793 I 0.827
GFI1B Ornithorhynchus anatinus ENSOANG00000014723 I 0.805
ENSNLEG00000012963 Nomascus leucogenys ENSNLEG00000012963 I 0.827
ENSNLEG00000010470 Nomascus leucogenys ENSNLEG00000010470 I 0.781
ENSMPUG00000012489 Mustela putorius furo ENSMPUG00000012489 I 0.823
GFI1 Loxodonta africana ENSLAFG00000018346 I 0.781