ZNF444 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000167685 T095061_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
ZNF444
M04529_2.00
Homo sapiens
NCRTCCCCCTCCCCCH

DGGGGGAGGGGGAYGN
SELEX
Yin et al.(2017)
ZNF444_FL_HT-SELEX
(Direct) (Direct)
ZNF444
M04530_2.00
Homo sapiens
NCRWCCCCCTCCCCCH

DGGGGGAGGGGGWYGN
SELEX
Yin et al.(2017)
ZNF444_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000338860 C2H2 ZF 179 201
ENSP00000338860 C2H2 ZF 207 229
ENSP00000338860 C2H2 ZF 250 272
ENSP00000338860 C2H2 ZF 278 300
ENSP00000468069 C2H2 ZF 178 200
ENSP00000468069 C2H2 ZF 206 228
ENSP00000468069 C2H2 ZF 249 271
ENSP00000468069 C2H2 ZF 277 299

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

17 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ZNF444 Gorilla gorilla ENSGGOG00000027831 I 0.827
ENSPANG00000014394 Papio anubis ENSPANG00000014394 I 0.827
ENSPPYG00000010439 Pongo abelii ENSPPYG00000010439 I 0.827
ENSNLEG00000010746 Nomascus leucogenys ENSNLEG00000010746 I 0.827
ENSCSAG00000001682 Chlorocebus sabaeus ENSCSAG00000001682 I 0.827
ZNF444 Callithrix jacchus ENSCJAG00000020269 I 0.826
ZNF444 Otolemur garnettii ENSOGAG00000033824 I 0.822
ZNF444 Microcebus murinus ENSMICG00000017167 I 0.822
ZNF444 Pan troglodytes ENSPTRG00000011535 I 0.820
ZNF444 Canis familiaris ENSCAFG00000024225 I 0.813
ENSOCUG00000015343 Oryctolagus cuniculus ENSOCUG00000015343 I 0.810
ENSSTOG00000024137 Ictidomys tridecemlineatus ENSSTOG00000024137 I 0.806
ZNF444 Loxodonta africana ENSLAFG00000027089 I 0.803
ZNF444 Dasypus novemcinctus ENSDNOG00000042117 I 0.801
ZNF444 Macaca mulatta ENSMMUG00000017498 I 0.773
ZNF444 Ochotona princeps ENSOPRG00000000077 I 0.766