E4F1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000167967 T095066_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
E4F1
M10255_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E4F1_Q6_01
(Direct) (Direct)
E4F1
M10256_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$E4F1_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
E4f1
M10339_2.00
Mus musculus Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$PHIAP3_03
0.817 0.971
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000301727 C2H2 ZF 192 214
ENSP00000301727 C2H2 ZF 220 242
ENSP00000301727 C2H2 ZF 248 269
ENSP00000301727 C2H2 ZF 435 457
ENSP00000301727 C2H2 ZF 463 485
ENSP00000301727 C2H2 ZF 491 513
ENSP00000301727 C2H2 ZF 519 541
ENSP00000301727 C2H2 ZF 547 569
ENSP00000301727 C2H2 ZF 575 596
ENSP00000454652 C2H2 ZF 170 192
ENSP00000454652 C2H2 ZF 198 220
ENSP00000454652 C2H2 ZF 226 247
ENSP00000456760 C2H2 ZF 192 214
ENSP00000456760 C2H2 ZF 220 242
ENSP00000456760 C2H2 ZF 248 269
ENSP00000456760 C2H2 ZF 372 392
ENSP00000456760 C2H2 ZF 398 419
ENSP00000457672 C2H2 ZF 192 214
ENSP00000457672 C2H2 ZF 220 242
ENSP00000457672 C2H2 ZF 248 269
ENSP00000457672 C2H2 ZF 435 457
ENSP00000457672 C2H2 ZF 463 485
ENSP00000457672 C2H2 ZF 491 513
ENSP00000457672 C2H2 ZF 519 541
ENSP00000457672 C2H2 ZF 547 569
ENSP00000457672 C2H2 ZF 575 596

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
E4F1 Callithrix jacchus ENSCJAG00000015000 I 0.827
ENSPPYG00000006994 Pongo abelii ENSPPYG00000006994 N 0.827
ENSNLEG00000009261 Nomascus leucogenys ENSNLEG00000009261 I 0.826
E4F1 Gorilla gorilla ENSGGOG00000014241 I 0.826
ENSPANG00000017016 Papio anubis ENSPANG00000017016 I 0.825
E4F1 Macaca mulatta ENSMMUG00000019235 I 0.825
ENSCSAG00000010850 Chlorocebus sabaeus ENSCSAG00000010850 I 0.825
ENSP00000301727 Macaca fascicularis ENSP00000301727 I 0.825
E4F1 Loxodonta africana ENSLAFG00000000725 I 0.822
E4F1 Pteropus vampyrus ENSPVAG00000005098 I 0.818
E4F1 Cavia porcellus ENSCPOG00000002052 I 0.818
E4f1 Mus musculus ENSMUSG00000024137 D 0.817
E4F1 Ochotona princeps ENSOPRG00000002573 I 0.817
E4F1 Oryctolagus cuniculus ENSOCUG00000025484 I 0.817
E4F1 Microcebus murinus ENSMICG00000005892 I 0.817
E4F1 Tursiops truncatus ENSTTRG00000008208 I 0.816
ENSP00000301727-D1 Bos grunniens ENSP00000301727-D1 I 0.816
E4F1 Equus caballus ENSECAG00000008036 I 0.816
ENSOARG00000017910 Ovis aries ENSOARG00000017910 I 0.816
E4F1 Sus scrofa ENSSSCG00000008047 I 0.816
E4F1 Bos taurus ENSBTAG00000009961 I 0.816
E4f1 Rattus norvegicus ENSRNOG00000009224 I 0.816
ENSMPUG00000015378 Mustela putorius furo ENSMPUG00000015378 I 0.815
ENSAMEG00000017837 Ailuropoda melanoleuca ENSAMEG00000017837 I 0.815
E4F1 Otolemur garnettii ENSOGAG00000006594 I 0.815
E4F1 Dasypus novemcinctus ENSDNOG00000016503 I 0.812
E4F1 Erinaceus europaeus ENSEEUG00000011307 N 0.810
E4F1 Procavia capensis ENSPCAG00000004337 I 0.808
Myotis_brandtii_E4f1_10005619 Myotis brandtii Myotis_brandtii_E4f1_10005619 I 0.808
E4F1 Myotis lucifugus ENSMLUG00000016786 I 0.808
ENSSTOG00000013171 Ictidomys tridecemlineatus ENSSTOG00000013171 I 0.805
E4f1 Dipodomys ordii ENSDORG00000001751 I 0.804
ENSAPLG00000016376 Anas platyrhynchos ENSAPLG00000016376 N 0.789