E4F1 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000167967 T095066_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E4F1
M10255_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E4F1_Q6_01		 (Direct) (Direct)
E4F1
M10256_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$E4F1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
E4f1
M10339_2.00 		Mus musculus Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$PHIAP3_03 		0.817 0.971
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000301727 C2H2 ZF 192 214
ENSP00000301727 C2H2 ZF 220 242
ENSP00000301727 C2H2 ZF 248 269
ENSP00000301727 C2H2 ZF 435 457
ENSP00000301727 C2H2 ZF 463 485
ENSP00000301727 C2H2 ZF 491 513
ENSP00000301727 C2H2 ZF 519 541
ENSP00000301727 C2H2 ZF 547 569
ENSP00000301727 C2H2 ZF 575 596
ENSP00000454652 C2H2 ZF 170 192
ENSP00000454652 C2H2 ZF 198 220
ENSP00000454652 C2H2 ZF 226 247
ENSP00000456760 C2H2 ZF 192 214
ENSP00000456760 C2H2 ZF 220 242
ENSP00000456760 C2H2 ZF 248 269
ENSP00000456760 C2H2 ZF 372 392
ENSP00000456760 C2H2 ZF 398 419
ENSP00000457672 C2H2 ZF 192 214
ENSP00000457672 C2H2 ZF 220 242
ENSP00000457672 C2H2 ZF 248 269
ENSP00000457672 C2H2 ZF 435 457
ENSP00000457672 C2H2 ZF 463 485
ENSP00000457672 C2H2 ZF 491 513
ENSP00000457672 C2H2 ZF 519 541
ENSP00000457672 C2H2 ZF 547 569
ENSP00000457672 C2H2 ZF 575 596

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

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34 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action