ZNF354A (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000169131 T095074_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. Biomarker of in situ carcinoma and seminoma. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF354A
M07622_2.00		 Homo sapiens
RTTTARHCCATTTAC
GTAAATGGDYTAAAY		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF354A.RCADE.OriginalMapping		 (Direct) (Direct)
ZNF354A
M08331_2.00		 Homo sapiens
RTTTARDCCATTTAY
RTAAATGGHYTAAAY		 ChIP-seq
Schmitges et al.(2016)
O60765_5-9.RCADE		 (Direct) (Direct)
ZNF354A
M08914_2.00		 Homo sapiens
DTTYHDNYCHTTTMYWTTTADTGW
WCAHTAAAWRKAAADGRNHDRAAH		 Misc
Kulakovskiy et al.(2013)
Z354A_HUMAN.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZNF354B
M07653_2.00 		Homo sapiens
RDWTAKYYCMTT
AAKGRRMTAWHY		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZNF354B.RCADE.ReprocessedData 		0.779 0.933
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000337122 C2H2 ZF 214 236
ENSP00000337122 C2H2 ZF 242 264
ENSP00000337122 C2H2 ZF 270 292
ENSP00000337122 C2H2 ZF 298 320
ENSP00000337122 C2H2 ZF 354 376
ENSP00000337122 C2H2 ZF 382 404
ENSP00000337122 C2H2 ZF 410 432
ENSP00000337122 C2H2 ZF 438 460
ENSP00000337122 C2H2 ZF 466 488
ENSP00000337122 C2H2 ZF 494 516
ENSP00000337122 C2H2 ZF 522 544
ENSP00000337122 C2H2 ZF 550 572
ENSP00000337122 C2H2 ZF 578 600

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

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50 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action